Before addressing your question, may I offer a comment about
one line you might consider removing from your signature? Most doctors won't give you a prognosis of "X years". They're guessing. We don't have the technology yet to know how long any individual has! There are broad statistics, but you aren't a statistic. Don't quit buying green bananas yet! It's easy to become fixated on a prognosis like that, and lose the joy of the years you have remaining in decent health.
To your question, my Lupron shots were only achy for a day or so, feeling like a bruise that cleared right up.
By your signature, you were already metastatic when diagnosed with a G8. Did your docs discuss whether or not you would be eligible for intermittent HT? If so, then you'd want to continue with shots because they can be interrupted. That seems a bit unlikely with your diagnosis.
If not, if you'll be permanently on HT, then it may be worth considering orchiectomy. I know it's a little tough psychologically, but so is a chemically-castrating injection on a regular basis. One simple surgery and it's done. Our doctors fight this option, and I'll cynically observe that part of that is losing a long-term revenue stream (each shot can be a few thousand dollars in the US).
Some studies have also shown reduced risk of some side effects for orchiectomy vs Lupron and the like.
If my case recurs, I expect to go back on HT early and permanently. I fully intend to take the surgical option at that point.
55@Dx on 4/16/13. PSA 5.2, G9(5+4), PNI+, cT3a by MRI.
IGRT - 44 sessions (79.2 Gy, 50.4 Gy pelvic)
ADT2 - Lupron+Casodex (5/13-3/16)
8/13-5/16 <0.1 (ADT2)
5/16-3/17 recovering from ADT2
3/17-7/18 ~ 0.6 - 0.8 (no TX)
10/18 = 1.0My Story