Here is the situation IMO, though I could be wrong: bacteria do not evolve drug resistance, although selective breeding is certainly involved.
You know how when a plague would come in and wipe out millions, but some people who lived among the dying were not touched by the disease, or at least survived it? Then when 75%- or 90% - of the population is gone, all (or almost all) you have left are the people who are naturally resistant. Now if someone newly infected with that disease comes into that town, they can not hurt those survivors.
These people who can not be hurt by the disease did not evolve resistance to said disease, they already had such when the disease showed up, and so they survived, and likely passed on their resistance (stronger immune system when it comes to this disease) to their off spring. It will take a long time for the few who did not have resistance but survived by some other means- or new people moving in who do not have resistance- to reproduce and dilute the population to the point where this disease can hurt large numbers in this village again.
When E. Coli become resistant to the newest antibiotics, they do not evolve some change, some new characteristic. ( IMO, I'm sure many disagree ) Bad bugs(let's say E. Coli) compete for resources against other bad bugs- their brothers in the same species you might say- and also against other so called good bacteria. When we go in and kill 99% with an antibiotic, a few are sometimes left alive. These are the ones the antibiotic could not kill. But their brothers of the same species are dead, as well as many competitors from other species, including good bugs that normally fight them in competition for resources. Those others are dead, but a minute # of these other E. Coli are still alive. Hopefully now that your health has returned, your immune system can keep these small #s under control. And maybe you can restore- in large #s - the other good bacteria that fight against them.
But if your immune system gets low for some reason-as happens so often in winter and flu season- those super bugs may start growing. (Or, if you are- maybe in addition- exposed to a large # of the resistant bacteria from an external source: sick people) And you go get the same antibiotic you got last time, once again wiping out your good bugs- that you have painstakingly and hopefully restored- but those surviving E. Coli? They just laugh at your antibiotic.
And every time we take an AB for a virus, which is unaffected by the AB- we as always wipe out the good bugs, which compete against bad bugs and even viruses. Plus, now we need stronger and stronger ABs which can kill the resistant survivors of the previous ABs, which seem to have worse and worse unwanted side effects.
What a vicious cycle we are in.
I still have not seen a study disproving the addition of IV Vitamin C being added to the protocols for treating sepsis in ICU at - Eastern Virginia Medical School, with spectacular results. I hope it is helpful, as apparently bacteria and viruses have never "evolved" a resistance to this vitamin, one of natures ways of fighting disease. So I hope the RCTs which they have finally started prove the claims of that well known ICU doc, Paul E. Marik. Because it sounds like we are going to need it. BTW, humans have a defect keeping us from making our own vitamin C. Most mammals can make vitamin C in huge amounts when needed. I sometimes think this is why animals are so less susceptible to drinking dirty water and eating dirty food, things that would kill us quickly. But I'm not sure, it's just a thought.
Post Edited (BillyBob@388) : 12/22/2018 12:39:09 PM (GMT-7)