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Time interval to biochemical failure as a surrogate end point in locally advanced prostate cancer: A

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Time interval to biochemical failure as a surrogate end point in locally advanced prostate cancer: A  
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Skypilot56
Veteran Member
Joined : Mar 2017
Posts : 893
Posted 1/18/2019 6:56 PM (GMT -7)
Just run across this on my MD Linx site

Larry
Male 62 DX @ 60
Dad had PC
2002. Psa. .08
2014. Psa. 3.8
2016. Psa. 19
3-08-17 RP Mayo, Mn
Gleason 9, pt3b, SV + 1 nerve, N-Margins 35 LN removed clear
Prostrate 45 grams
4-20-17 Incarcerated Umbilical Hernia
6-13-17 psa 0.13
7-19-17 psa 0.12 3TMRI with coil - clear
10-11-17 psa 0.16
10-12-17 Lupron
12-13-17 psa <0.10
12-18-17 SRT
2-7-18 SRT done 72gy
4-25-18 psa <0.10
10-29-18 psa <0.10
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Skypilot56
Veteran Member
Joined : Mar 2017
Posts : 893
Posted 1/18/2019 6:58 PM (GMT -7)
somebody know how to post a link to this?

Time interval to biochemical failure as a surrogate end point in locally advanced prostate cancer: Analysis of...

Journal of Clinical Oncology

January 18, 2019
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Nytngale
Regular Member
Joined : Jul 2018
Posts : 100
Posted 1/18/2019 9:42 PM (GMT -7)
http://ascopubs.org/doi/abs/10.1200/JCO.18.00154?af=R&

Cut and paste for browser - would not copy as a hyperlink.
Husband’s info: Dx July 2018. 6 of 12 cores positive - 3 cores 4+3 and 3 cores 4+4. PSA 5.7 2/18, 6.2 5/18 RALP 8/29/18. 9/27/18. Path report: G9 4+5 pT3b, N1. EPE+, SVI +, pos margin left bladder neck, lymph nodes 1/9 positive, prostate 48g, prostate involvement 35%
12/18/18 Axumin PET scan - negative
12/19/18 Casodex; 1/2/19 Eligard
9/27/18 1st post-op PSA 0.06; 12/6 0.06; 1/2/19 <0.04
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BillyBob@388
Veteran Member
Joined : Mar 2014
Posts : 3537
Posted 1/18/2019 10:20 PM (GMT -7)
Interesting. I wonder how time to BCR effects prognosis for those with either RP or RT only?

Here is one answer to my question: https://www.renalandurologynews.com/aua-2010-annual-meeting/time-to-bcr-affects-survival-likelihood-in-high-risk-pca-patients/article/171394/
PSA 10.9 ~112013
Bx on 112013 at age ~65yrs, with 5 of 12 pos, G9(5+4), T2B.
RALP with lymph nodes at Vanderbilt 021914. (nodes clear, SV+, G9 down graded to 4+5, 1 focal margin )
only rare pad use after 1 year
PSA <.01 on 6/14 and all until 9/15 = .01, still .01 9/16, .02 on 3/17,6/17,10/17, .06 1/18, .06 4/18, <.05 7/18, .06 10/18, .06 01/19

Post Edited (BillyBob@388) : 1/18/2019 10:26:21 PM (GMT-7)

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F8
Veteran Member
Joined : Feb 2010
Posts : 4163
Posted 1/19/2019 2:18 AM (GMT -7)
http://ascopubs.org/doi/abs/10.1200/jco.18.00154?af=r&
age - 63
12/09 - PSA 6.8
G7 - 3+4 - all 12 cores pos
HT, BT, IGRT
6/18 - 8-year post treatment PSA .1!
PSAs .2, .3, .2, .3, .2, .1, .2, .2, .1, .1, .1, .1, .1

/instagram.com/edraderphotography/
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Skypilot56
Veteran Member
Joined : Mar 2017
Posts : 893
Posted 1/19/2019 3:50 AM (GMT -7)
Thnx for the link

Larry
Male 62 DX @ 60
Dad had PC
2002. Psa. .08
2014. Psa. 3.8
2016. Psa. 19
3-08-17 RP Mayo, Mn
Gleason 9, pt3b, SV + 1 nerve, N-Margins 35 LN removed clear
Prostrate 45 grams
4-20-17 Incarcerated Umbilical Hernia
6-13-17 psa 0.13
7-19-17 psa 0.12 3TMRI with coil - clear
10-11-17 psa 0.16
10-12-17 Lupron
12-13-17 psa <0.10
12-18-17 SRT
2-7-18 SRT done 72gy
4-25-18 psa <0.10
10-29-18 psa <0.10
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