I wouldn't worry too much about
that one. Huge retrospective study, lots of caveats. It focuses almost exclusively on risk ratios, and there are so many confounding factors it would take a lot of study to figure out how they made any conclusions. The only comment I could find about
the underlying actual risk is this: "Most commonly, gynecomastia is physiologic, with one-third to two-thirds of men over the age of 50 having some degree of gynecomastia on examination. Nonphysiologic gynecomastia can be the result of medical conditions such as primary or secondary hypogonadism, Klinefelter’s syndrome, renal failure, alcoholic cirrhosis and hyperthyroidism. 10-25% of gynecomastia cases are attributed to medications, including 21% of symptomatic cases."
Here's a link to the actual study (pdf warning, and it's a funky-looking link so it may not work for everyone): Statin Medications and the Risk of Gynecomastia
Ok, so untangling the stats a little, 1/3 - 2/3 of men over 50 have some gyno. Call it half. 10-25% are due to medications somehow. So, 25% of 50% is... 12.5%. Alrighty, so now the study says a risk ratio of what, 1.38? So that takes the medication-induced gyno rate (grossly generalized) from 12.5% all the way up to 17.5%. An increase in the absolute risk of something like 5%. And that could range a lot too if you take the extremes of the numbers I multiplied. This is just to derive a middle-ish estimate from their study.
So, your doctor can help you decide if the reduction of cholesterol-induced cardiac risk is worth a maybe, maybe 5% increased risk of gynecomastia.
(I'll also express my usual cynicism about
studies in general. It is helpful to keep in mind that studies exist to make money for their sponsors, to justify grants, and to allow researchers/professors/doctors to attempt to justify their salaries, treatments, and/or equipment. They're all agenda driven, since they all cost money to perform. Usually a LOT of money.)
55@Dx on 4/16/13. PSA 5.2, G9(5+4), PNI+, cT3a by MRI.
IGRT - 44 sessions (79.2 Gy, 50.4 Gy pelvic)
ADT2 - Lupron+Casodex (5/13-3/16)
8/13-5/16 <0.1 (ADT2)
5/16-3/17 recovering from ADT2
3/17-7/18 ~ 0.6 - 0.8 (no TX)
10/18 = 1.0, 12/18 = 0.9My Story