Posted 7/2/2020 10:22 AM (GMT -6)
I just got back my 2 yr, 10 month uPSA result. This was the first time that I've gone 6 months between tests:
(3 m ) 0.010
(6 m ) 0.009
(9 m ) 0.007
(1 yr.) 0.018 ?
(13 m) 0.013 retest
(15 m) 0.012
(18 m) 0.015
(21 m) 0.015
(2 yr. ) 0.016
(28 m) 0.015
(34 m) <0.014
Of course I'm very pleased that I'm still stable or perhaps even a bit lower, but also annoyed and disappointed that Labcorp ran the test using equipment that has their previous lower limit of detection (LLD) and not the equipment they used to run all 10 of my previous tests, which was the <0.006 LLD. I just sent Labcorp a message on their portal -- most of the time they are good about responding. I said that I was a G 9 who is concerned about BCR and with this change in reporting, I can't compare my current PSA to my nadir of 0.007, nor can Labcorp or I accurately plot my trend.
If you say I'm nitpicking, I would agree; however, I specifically asked my uro if we could follow my PSA with the uPSA because I wanted to know what my PSA is and not what it's below.
Another reason I'm interested in accurate tracking is that I've modified my phytochemical-supplement routine, and I was curious to see if there was a PSA decrease, and, if so, to what extent. If my last value was actually, say, 0.013, I'm still essentially stable, given that 2 Standard Deviations for this assay is +/- 0.002.
Note that the Roche PSA assay Labcorp uses can actually detect down to 0.003, but this requires analyzers that Labcorp may not use. Or it may be that they aren't convinced of the reliability of results that low. In any case, they choose to report a LLD of <0.006 or <0.014 depending which analyzer is used to run the test. I have a feeling they will respond to my query saying that their uPSA test description/specifications does not actually state the LLD, probably for the reason that it can vary. Other guys on this and other Forums have had the <0.006 to <0.014 switch pulled on them, too.
On the more important point, I'm closing in on the 3-year post-op mark. One study found 75% of high-risk men encountering BCR did so in within the first 2 years post-op and 82% within 3 years.