I am so sorry about
your father; I hope he is not suffering.
I cannot answer your (highly specialized) question, but can say that even if there was an answer, it wouldn't necessarily apply to your Dad's case. It is often said here that each case is different (true).
From the data you provided it appears that abiraterone may not have been effective the first time around (2016). And it also looks that it is not 'working' this time around. But maybe there will be better news with the next PSA test. How is he dealing with the bone metastases?
All I can say is that his doctors are trying every way to help.
Post Edited (Sr Sailor) : 7/27/2019 12:44:04 PM (GMT-6)