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Medical breakthroughs initially ridiculed and rejected (Article)

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81GyGuy
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Joined : Oct 2012
Posts : 3102
Posted 7/30/2019 9:40 AM (GMT -7)
Interesting read below about significant medical breakthroughs that were rejected out of hand when they were first announced, but which later proved to be valid.

Cases like Semmelweis and handwashing, germs as disease agents, and even Mendel's discoveries about heredity: ideas that were roundly mocked by the "establishment" when they first came out.

In particular, read the section in the article about cancer immunology: "... when immunologist James Allison first suggested his research interest in T cells, his mentors discouraged him. "Tumor immunology had such a bad reputation," he told the New Yorker in 2012. "Many people thought that the immune system didn't play any role in cancer."

So even today this can be an issue.

But the medical establishment as rejector isn't all to blame here. It does have the responsibility to act as guardian, to catch and reject those ideas that are clearly quackery when they first appear, and which richly deserve the ridicule they come to receive.

This is especially true today in the age of the Internet, when all sorts of cure-claims pop up on websites everywhere and all the time, with no scientific basis at all.

A large part of the problem is that major medical, or any scientific for that matter, breakthroughs must inevitably seem "quirky" or even incredible at first. This is simply because they are the amazing, unexpected, new discoveries that have become necessary. That is, if an easy solution had been available, it would have already been found by now. It hasn't, so a more radical new solution must be sought, "thinking outside the box" as they say, and this new thing is it, despite how unlikely it may seem at first. But this often doesn't sit well with much of the mainstream medical community, used to thinking along "traditional" lines, and now uncomfortable with the prospect having to change.

So that's the fine line the medical establishment must walk: rightly rejecting the false claims of some newly proposed (wrong) thing, but then not wrongly rejecting as well a valid new thing, simply because it "seems" like it's quackery.

As a result we, and I mean we here on this forum, may often find ourselves in a curious position when reading about a newly promised "cure," or "major advance" in cancer research or treatment: that maybe this is worthless, or maybe it really is the "big one."

We may hope to ourselves that, yes indeed, this is the find that will change everything, but only time will eventually decide that for us.

https://forum.facmedicine.com/threads/medical-breakthroughs-that-were-initially-ridiculed-or-rejected.26394/
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InTheShop
Elite Member
Joined : Jan 2012
Posts : 11468
Posted 7/30/2019 9:49 AM (GMT -7)
so does this mean the baking soda thing might be true ...
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Blackjack
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Joined : Sep 2017
Posts : 805
Posted 7/30/2019 10:04 AM (GMT -7)
Arthur Schopenhauer wrote that "All truth passes through three stages. First, it is ridiculed. Second, it is violently opposed. Third, it is accepted as being self-evident."

The brief, now flamed-out history of prostate cancer overtreatment revealed these three stages in rather rapid succession...
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mattam
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Joined : Aug 2015
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Posted 7/30/2019 11:21 AM (GMT -7)
I think we see a form of what the OP posted right here on the forum. Occasionally a member reports their doctor hasn't recommended, or has even resisted the suggestion, for the early use of Zytiga, Xtandi, or chemo with Lupron. I suppose this could be due to resistance to change, or just ignorance from not staying current with treatments.
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Blackjack
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Posts : 805
Posted 7/30/2019 11:39 AM (GMT -7)

mattam said...
I think we see a form of what the OP posted right here on the forum. Occasionally a member reports their doctor hasn't recommended, or has even resisted the suggestion, for the early use of Zytiga, Xtandi, or chemo with Lupron. I suppose this could be due to resistance to change, or just ignorance from not staying current with treatments.

Most of the cases like you've described which I've seen here have been from the patient's incomplete understanding (or misunderstanding) which case characteristics the specific treatment is for...as if the patient's medical education is superior to his doctor's medical education...
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mattam
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Joined : Aug 2015
Posts : 2966
Posted 7/30/2019 11:47 AM (GMT -7)
"..as if the patient's medical education is superior to his doctor's medical education..."

The patient's medical education is not superior to the doctor's. Patients sometimes have an awareness of current stadards of care that not all doctors have.
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alephnull
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Joined : Dec 2013
Posts : 1977
Posted 7/30/2019 12:04 PM (GMT -7)
mattam,
Exactly! This is especially true with PCPs and Urologists who pretend to be Oncologists.
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Blackjack
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Joined : Sep 2017
Posts : 805
Posted 7/30/2019 1:55 PM (GMT -7)
uh-huh
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halbert
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Joined : Dec 2014
Posts : 5030
Posted 7/31/2019 4:10 AM (GMT -7)
The history of science generally is full of similar examples. Gallileo and his famous, "and yet it moves" is only one famous example. Frequently it is about questioning the accepted wisdom (was the original radical mastectomy that included muscle removal and full lymph node excision really needed?), or more accurately about looking at the accepted wisdom and saying, "well, we're close, but we're missing something". That's how it works.

It's only been in very recent time that the value and function of what used to be called intestinal flora, now is becoming the microbiome has been studied. Just a few years ago, if anyone had suggested just how important that system really is for our immune systems or overall health, they would have been laughed at.
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alephnull
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Posts : 1977
Posted 7/31/2019 6:29 AM (GMT -7)
Gut biome destruction, my NSHO is that the over prescription of anti-biotics has in part led to many health issues.
My particular case is in reference to Cipro for a urinary tract infection.
It killed much more than the bad stuff and that part of me has never been the same, no matter how much I consume probiotics (yogurt with active cultures) I haven't been able to overcome the problems that occured by Cipro use.
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Blackjack
Veteran Member
Joined : Sep 2017
Posts : 805
Posted 7/31/2019 7:30 AM (GMT -7)

alephnull said...
Gut biome destruction, my NSHO is that the over prescription of anti-biotics has in part led to many health issues.
My particular case is in reference to Cipro for a urinary tract infection.
It killed much more than the bad stuff and that part of me has never been the same, no matter how much I consume probiotics (yogurt with active cultures) I haven't been able to overcome the problems that occured by Cipro use.

I'd like to acknowledge the scope of this problem. I'm curious...do you recall how many times (perhaps an approximation) you were prescribed a round of Cipro? I've read of long-term "gut" issues after just two 5-day courses, 6-months apart (in a controlled study).

I might suggest that this is appropriate material for a thread of it's own...see how many others may have been impacted, although probably most men and their doctors have not put 1+1 together on this rather obscure issue.

Post Edited (Blackjack) : 7/31/2019 9:06:03 AM (GMT-6)

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alephnull
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Joined : Dec 2013
Posts : 1977
Posted 7/31/2019 9:15 AM (GMT -7)
1 ten round course a little over 20 years ago.

Might I had, adding pro-biotics has helped some but not fixed the issues AND the pro-biotics is not a 2 week, 2 month, or 2 year thing. It pretty much (for me)has to be done fore ever more.

And the use of pro-biotics gave almost immediate relief (after a week or two of use)

Post Edited (alephnull) : 7/31/2019 10:21:51 AM (GMT-6)

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