Just wanted to post an update on my dad:
1 month since starting Abiraterone acetate (Zytiga generic) and 10 mg prednisone PSA went down from 4.46 on August 03 to 0.837 on September 06 and from initial PSA of 114 on diagnosis on June 24, 2019. Hoping to have a long run on Abiraterone.
On the not so positive, but expected front - he is having side effects from the hormone therapy - hot flushes, fatigue and frequent bouts of constant itching (this one is not what is frequently witnessed - not sure if it is because of zytiga, pred. or the B12/D3 medication (He had low B12 and D3 levels in August, for which the doctor had recommended supplements - anyone else experienced itching?. As long as the beast is under control, i am not complaining about
The liver numbers (SGPT/SGOT), B12, D3 were within the normal limits, T. Bilirubin was marginally high at 1.03 (normal range is 0.2-1.0). The postprandial blood sugar levels were however elevated at 218 (70-140 is the normal range).
The MO said the results were good, not to worry about
the T. bilirubin, the elevated sugar levels are due to the 10 mg prednisone and asked us to lower the dose to 5 mg pred. once a day. Now to visit him after 2 months. Routing for undetectable PSA for him then and hoping the lower pred. will control the sugar and limit the side effects to some extent. Have read about
Dr. Myers advocating use of Metformin for advanced Pca. If the sugar levels are not in range during the next blood work - will ask the MO about
Also, the MO asked dad to take a 4mg Zoledronate IV. (zometa) for his bone strength. I asked if we should do a bone density check and whether he needs the zometa as his alk. phosphate is at 64 (normal 46-116) and he just has one pelvic bone met. The MO said that for his age of 75 and since he is on hormone therapy he should be taking it once every 3 months. So he had the Zoledronate 4 mg. IV. 24 hours post the infusion, he had an onset of nausea and fever, which kept him on his bed sleeping for most of the day. The next day he felt better with the effects subsiding. Anyone with stage 4 distant mets to lymph nodes/one or two bone mets on zometa and whether this has to be taken on an ongoing basis or intermittently will do - the side effects with its long term use are scary.Also, the MO did not recommend Celebrex with it and i have read Tall Allen post about
increased OS with addition of Celebrex to zometa but the reports were in 2016, anyone on the forum on celebrex and zometa?
Post Edited (givemesomesunshine) : 9/9/2019 7:08:36 AM (GMT-6)