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Purdue Pharma, at center of opioid epidemic, files for bankruptcy (OT)

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Pratoman
Forum Moderator
Joined : Nov 2012
Posts : 8426
Posted 9/19/2019 10:40 AM (GMT -7)
BillyBob, as i have said in the past, i am glad you are back, i place high value on your contriubutions to the forum. Just sayin .....
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ddyss
Regular Member
Joined : Apr 2017
Posts : 499
Posted 9/19/2019 11:00 AM (GMT -7)
Billy bob
I’m glad you are back and I love your posts. Yeah you are right , weed overdose deaths are rare but , weed leads to other death , it’s a very slippery slope. You go from weed to more potent things ..but you are right weed overdose deaths are rare. Maybe I should try it on the days I fast smile
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BillyBob@388
Veteran Member
Joined : Mar 2014
Posts : 4633
Posted 9/19/2019 11:40 AM (GMT -7)

Pratoman said...
BillyBob, as i have said in the past, i am glad you are back, i place high value on your contriubutions to the forum. Just sayin .....

ddyss said...
Billy bob
I’m glad you are back and I love your posts. Yeah you are right , weed overdose deaths are rare but , weed leads to other death , it’s a very slippery slope. You go from weed to more potent things ..but you are right weed overdose deaths are rare. Maybe I should try it on the days I fast smile

Thanks for the kind words, brothers! I just went to the pharmacist, bought some CBD oil again, and just ingested some. Let's see if that helps any. And if not then will a higher dose help? I just remembered that on my June UK trip as soon as I got to London I bought some, and took it at bedtime the entire trip plus finished it up and some left over here at home when I got back. I don't think my hip was bothering me near this much during that time. Was it the CBD? Who the heck knows, I am trying it again to see.
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ddyss
Regular Member
Joined : Apr 2017
Posts : 499
Posted 9/19/2019 6:12 PM (GMT -7)
For what it’s worth ...

Absorption of CBD When Ingested or Taken Sublingually

Without doubt, the most common method of administering CBD is orally, or via the mouth. It is quick, easy to dose, and convenient. When you take CBD this way, however, whether you eat it in food or swallow drops, it must first go through the digestive system. This process is lengthy. From the digestive tract, CBD then travels to the hepatic portal system, through the portal vein, and on into the liver.

In the liver, processes become a bit tricky. The U.S. National Library of Medicine published a study, (Ujvary and Hanus, 2016), detailing how the liver metabolizes CBD compounds. Called the “first pass effect”, CYP450 oxidases enzymes in the liver, which have mixed functions, break CBD down, reducing cannabidiol concentration significantly before sending the leftovers to the bloodstream.

Ingesting CBD, despite being the easiest method of delivery, is not particularly efficient at absorbing CBD in high concentrations and can take as long as two hours to work. However, another study (Huestis, 2009), also published by the U.S. National Library of Medicine, suggests that swallowing CBD with fatty acids may bypass this “first pass effect” and increase absorption rates of CBD after ingestion.

You can take CBD sublingually, which means holding it under the tongue for a minute or two before swallowing. This method allows the mucus membranes of the mouth to absorb CBD instead, bypassing the digestive system and metabolism in the liver entirely. Since no enzymes break the CBD molecules down and it does not travel through the stomach, CBD is able to reach the bloodstream faster.
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BillyBob@388
Veteran Member
Joined : Mar 2014
Posts : 4633
Posted 9/20/2019 7:50 AM (GMT -7)

ddyss said...
For what it’s worth ...

Absorption of CBD When Ingested or Taken Sublingually

Without doubt, the most common method of administering CBD is orally, or via the mouth. It is quick, easy to dose, and convenient. When you take CBD this way, however, whether you eat it in food or swallow drops, it must first go through the digestive system. This process is lengthy. From the digestive tract, CBD then travels to the hepatic portal system, through the portal vein, and on into the liver.

In the liver, processes become a bit tricky. The U.S. National Library of Medicine published a study, (Ujvary and Hanus, 2016), detailing how the liver metabolizes CBD compounds. Called the “first pass effect”, CYP450 oxidases enzymes in the liver, which have mixed functions, break CBD down, reducing cannabidiol concentration significantly before sending the leftovers to the bloodstream.

Ingesting CBD, despite being the easiest method of delivery, is not particularly efficient at absorbing CBD in high concentrations and can take as long as two hours to work. However, another study (Huestis, 2009), also published by the U.S. National Library of Medicine, suggests that swallowing CBD with fatty acids may bypass this “first pass effect” and increase absorption rates of CBD after ingestion.

You can take CBD sublingually, which means holding it under the tongue for a minute or two before swallowing. This method allows the mucus membranes of the mouth to absorb CBD instead, bypassing the digestive system and metabolism in the liver entirely. Since no enzymes break the CBD molecules down and it does not travel through the stomach, CBD is able to reach the bloodstream faster.


Good info. I blew my clinical trial N=1, but still somewhat interesting results. I think I will report on that in a new thread, to avoid hijacking.
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