For what it’s worth ...
Absorption of CBD When Ingested or Taken Sublingually
Without doubt, the most common method of administering CBD is orally, or via the mouth. It is quick, easy to dose, and convenient. When you take CBD this way, however, whether you eat it in food or swallow drops, it must first go through the digestive system. This process is lengthy. From the digestive tract, CBD then travels to the hepatic portal system, through the portal vein, and on into the liver.
In the liver, processes become a bit tricky. The U.S. National Library of Medicine published a study, (Ujvary and Hanus, 2016), detailing how the liver metabolizes CBD compounds. Called the “first pass effect”, CYP450 oxidases enzymes in the liver, which have mixed functions, break CBD down, reducing cannabidiol concentration significantly before sending the leftovers to the bloodstream.
Ingesting CBD, despite being the easiest method of delivery, is not particularly efficient at absorbing CBD in high concentrations and can take as long as two hours to work. However, another study (Huestis, 2009), also published by the U.S. National Library of Medicine, suggests that swallowing CBD with fatty acids may bypass this “first pass effect” and increase absorption rates of CBD after ingestion.
You can take CBD sublingually, which means holding it under the tongue for a minute or two before swallowing. This method allows the mucus membranes of the mouth to absorb CBD instead, bypassing the digestive system and metabolism in the liver entirely. Since no enzymes break the CBD molecules down and it does not travel through the stomach, CBD is able to reach the bloodstream faster.
Good info. I blew my clinical trial N=1, but still somewhat interesting results. I think I will report on that in a new thread, to avoid hijacking.