I was diagnosed w/ T2D about 15 years back and have taken metformin ever since. Highest dose - 2000 mg daily. Coming up on my 4th RALP anniversary. Pathology had me at 'high risk' with pT3a - albeit 3+4. Labcorp says I'm still in the zero club (knock on wood). Does metformin have anything to do with that? Who knows? There's probably some other guy out there with my pathology taking metformin who relapsed. I stopped taking Resveratrol and Cayenne caps about 9 month ago. Cut back on Turmeric too. So far so good. No reason to believe those kept me in the zero club at this point. Everybody's situation and body chemistry is different. There's so many factors involved in BCR it's hard to pinpoint one or two.
There's been some very interesting clinical trials in the use of metformin to prevent or delay recurrence for different cancers. To my knowledge (which is severely limited) the drug does not have any such indication. And I have no clue how freely a licensed doc in the states can prescribe it for such in a legal sense. But in my non-professional opinion - if a non-diabetic man w/ Pca has been duly informed of whatever side effects or complications may arise while taking metformin - and he wants to roll the dice - he should have that right to do with his body as he chooses.............. SJO, I found your comment about metformin lowering testosterone of interest, particularly since I take the max dose.
Could you tell me where you read or heard such a thing?
At one time I read the entire package insert on the product and do not recall any mention of metformin lowering testosterone. Perhaps I missed it. But something that important would have to be disclosed to users and prescribers.
Thanks for any further information you might be able to share.
Yes, Metformin might well help with PC. As apparently does diagnoses of Type 2 Diabetes(aka high insulin/high insulin resistance), which leads to various treatments for T2D, including diet, exercise, Metformin and other drugs. All of which leads to having T2D being called "protective" against PC. Of course it is not, the treatment is what is protective.
People who are treated for diabetes (obviously you already know this) usually improve their insulin levels and insulin resistance with diet, exercise and/or drugs like Metformin. Thus, many other disease processes such as various cancers, including PC, which tend to be made worse by high blood insulin, might be improved. Studies I have in the past linked to have indicated, the guys with the highest blood insulin are 3-8 times higher risk for PC(or perhaps it was worse outcome for guys who had PCa?) than the guys with the lowest levels.
Or, with no drugs at all, blood insulin levels can be drastically lowered by fasting and or lowering carbs. If there is no food going in, or even just no carbs(as well as not much protein), the pancreas will not be called on by the body to produce much insulin at all. Just as a T2 diabetic who has advanced to the point of needing to inject insulin must be very careful to also eat when he injects that insulin. If he doesn't eat, or maybe even if he just doesn't eat carbs, he won't be needing that insulin and injecting it can lead to a hypoglycemic coma. Point being: metformin(with some possible SEs) improves over all health by lowering insulin and/or increasing insulin sensitivity. Fasting and/or low carb eating also lower insulin and improve/increase insulin sensitivity. As does, I'm fairly sure, exercise.
Post Edited (BillyBob@388) : 12/15/2019 4:13:03 PM (GMT-7)