An MRI and a biopsy can each miss cancer, but the a 12-core biopsy plus
cores in MRI lesions graded PIRADS 3 to 5 lowers the false negative rate. Again, an MRI can miss small lesions that a random core can happen upon. Not even all PIRADS 5 lesions turn out to be PCa. I would follow my uro's advise, but also do some googling about
the AS protocols at the major PC centers. Johns Hopkins has one of the strictest protocols.
Another step would be getting a second opinion on your next positive biopsy slides from Dr. J. Epstein at Johns Hopkins. He's the gurus' guru on prostate pathology. It's not that expensive, your uro can have your slides sent directly, and you'll know with confidence what you are dealing with and whether or not you are a good AS candiate.
I myself would not opt for AS without first having a genomics test, like OncotypeDx or Decipher done on my biopsy slides. While G6 CANNOT metastasize, some men's G6 has genetic markers that make them a high risk of developing higher-grade lesions that can
metastasize. This is another topic you can bring up with your uro.
Post Edited (DjinTonic) : 1/13/2020 9:24:27 PM (GMT-7)