This may not be empirically correct, but it does seem as if there are a lot of men under 45 who are getting diagnosed these days--and they tend to be really severe cases. So, does it make sense to have PSA be part of a normal male blood panel starting at a young adult age?
To me that makes sense. Public-health policy seems to be driven with NTT, number to treat or number to test, which gives you a bird's-eye view, but an individual's view is different -- somebody
is in those small percentages, and I see nothing wrong with making sure it isn't you or a loved one. Also, we should look at what the "cost" is -- a blood test added on to the many you get for your PE. As many have said, the remedy for overtreating G6 men is not reduced testing, but rather better education about
AS. You can't find those low-risk G6 men who can go on AS without first finding all G6 men.
Let's hope liquid biopsies (on blood, urine) make it out of testing to mainstream soon. There are a small but unfortunate number of men with very aggressive PCa that doesn't raise PSA out of the normal range. That makes current screening practically useless.Clinical and Genomic Characterization of Low-Prostate-specific Antigen, High-grade Prostate Cancer
[2018, Full Text]
Low-PSA, high-grade prostate cancer has very high risk for PCSM, potentially responds poorly to androgen deprivation therapy, and is associated with neuroendocrine genomic features."Editorial on this study
Post Edited (DjinTonic) : 2/12/2020 9:41:18 AM (GMT-7)