Here's an article with some more recent references.
Thanks for the link! Interestinly, there is also this in that article:
Vitamin K is a group of naturally occurring fat-soluble chemicals characterized by a common naphthoquinone ring. This structural feature they share with some drugs used for cancer chemotherapy.
This partly explains why vitamin K has attracted interest in the prevention and treatment of cancer.
The anticancer effect of vitamin K was first reported about
60 years ago when the intravenous injection of the vitamin K3 (Menadione-synthetic form of vitamin K) extended the survival of inoperable bronchial carcinoma patients.
Vitamin K3 in combination with vitamin C enhances the suppression of cancer cell growth by activating oxidative stress. Oxidative stress refers to a disproportion between the production of reactive oxygen species in the cells and the ability of the organism to detoxify them or neutralize the resulting damage. Reactive oxygen species are intermediary products of many biological reactions. They contain oxygen and readily react with proteins, lipids, and DNA, often causing their damage. Examples of reactive oxygen species include peroxides, superoxide, hydroxyl radical and oxygen.".
Why is that interesting(to me at least)? Back when I got my high risk diagnosis, my PSA had been rising pretty rapidly. It even went up a good bit ( from 9 something to just shy of 11) during the 3 weeks I was waiting to see a urologist, during which time I had a round of Cipro, hoping to bring it down if it was prostatitis. At that time there was an FDA "orphan" drug being investigated called Apatone. It had a couple of very interesting placebo controlled trials, then it just disappeared, never to be heard of again far as I can tell. Maybe they dropped it because of the difficulty getting a patent(it was nothing more than a certain ratio of vitamin K3(synthetic K1) and vitamin C. Or maybe it was dropped for some other reason maybe, just no good, who knows? I linked these studies here back about
the time I joined.
So, as it was just a certain ratio of those 2 vitamins, I decided to take it at a dose = to about
10 gms of Vit C per day, along with however much Vitamin k3 that would be (there was a product called Prosstay back then that contained those ratios). I did this for the about
2 months after my G9 diagnosis as I tried to decide on RT vs surgery, ended up with surgery. Anyway, coincidentally I'm sure, for the first time in all the years I had been checking my PSA(a bit over a decade), after those 2 months- and following my biopsy(which can raise PSA for a while) and diagnosis- my PSA dropped about
25%. This reference in your article about
K3 combined with C is the first I have read about
that in many several years.