Who knows about
this? This is a Dr. Burzynski out of Texas who came up with this treatment and wa heavily prosecuted by the FDA for years. However, I found this study at Clinical trials dot gov where that had a look at his approach:
To determine the efficacy of Antineoplaston therapy in adults with persistent or recurrent brain tumors as measured by an objective response to therapy (complete response, partial response or stable disease).
To determine the safety and tolerance of Antineoplaston therapy in adults with persistent or recurrent brain tumors.
OVERVIEW: This is a single arm,
open-label study in which adults with persistent or recurrent brain tumors receive gradually escalating doses of intravenous Antineoplaston therapy (Atengenal + Astugenal) until the maximum tolerated dose is reached. Treatment continues for at least 12 months in the absence of disease progression or unacceptable toxicity. After 12 months, patients with a complete or partial response or with stable disease may continue treatment.
To determine objective response, tumor size is measured utilizing MRI scans, which are performed every 8 weeks for the first two years, every 3 months for the third and fourth years, every 6 months for the 5th and sixth years, and annually thereafter."
Recurrent brain tumors is a pretty grim prognosis, right? This means they have not been able to keep thes tumors from coming back with conventional treatment, hence the "recurrence"? But when I go to the "results" section of this trial, it looks pretty good to me. I have a young friend on home hospice right now after a couple of years of the most aggressive conventional( I think Mayo was involved) treatment for brain cancer, so I think this class of recurrent brain tumors being studied is quite bad. But I see people who had some seemingly very good responses with relatively very light negative side effects. The vast majority of the SEs only occur in 2.5% of the patients and at the worst about
I am seeing a median overall survival for recurrent Glioblastoma (same thing they are looking at in this study? Or different?) of 6.5 months, which is about
what my friend has experienced. But in these results I am seeing 6 month survival of 70%, 24 months 40%, and 60 months 23%. Isn't that better than expected? Again, with what seems like low SEs to me.
response to the treatment?
"Title Number of Participants With Objective Response Objective response rate per Response Assessment in Neuro-Oncology (RANO) for target lesions and assessed by MRI:
Complete Response (CR), disappearance of all disease sustained for at least four weeks;
Partial Response (PR), >=50% decrease in the sum of the products of of the greatest perpendicular diameters of all measurable enhancing lesions, sustained for at least four weeks;
Stable Disease (SD), < 50% decrease and < 25% increase in the sum of the products of of the greatest perpendicular diameters of all measurable enhancing lesions, sustained for at least 8 weeks;
Progressive Disease (PD), >=25% increase in the sum of the products of of the greatest perpendicular diameters of all measurable enhancing lesions compared to the lowest sum recorded.
Time Frame 12 months
Overall Number of Participants Analyzed 31
Measure Type: Number
Unit of Measure: Participants
Complete Response 4
Partial Response 5
Stable Disease 12
Progressive Disease 10 "
So 4 of 31 had a compete response, or "disappearance of all disease sustained for at least four weeks; ", with low severe SEs? Isn't that pretty good for recurrent brain cancer? Or am I missing something? Plus another 5 that had a partial response( >=50% decrease ) and 12 with stable disease ( < 50% decrease and < 25% increase). Nine of 31 progressed.
If someone knows more about
this, please correct me. Am I wrong to think those are pretty good results, after I suppose surgery and RT and chemo have failed, and without anything approaching the SEs of those approaches? Keep in mind this Dr. Burzynski was using this for all cancers, not just brain. If these results are as good as they appear(or maybe it is not?) for this rim brain cancer, why haven't we heard about
it? This study was done in 2003, and reported in 2016. Dr. Burzynski was doing his work and in combat with the FDA in the 1980s and early 90s.
If someone knows more about
this, fill me in. But going by this study, looks to me like this might have some potential, or even a lot of potential. But there may be a lot more that has come out about
this that discredits it.https://clinicaltrials.gov/ct2/show/results/nct00003457