Hi DonJ. Sorry you're at this decision point in your PCa journey! When you speak of "doing nothing," if your PSA is doubling, your cancer is certainly doing something -- perhaps forming micromets. I don't think you can look at the possibility of clinically progression-free months in isolation -- you don't know how many months your lifespan could be shortened by waiting. In other words X months up-front could actually mean many more than X months overall.
As far as that trial, I would search (on pubmed
or google scholar
) for recent studies (including review papers) to see if either arm B or C has a meaningful advantage according to other studies (probably not), since you could get randomized to any arm. (I checked and the randomization is 1 : 1 : 1). Since it's an
open-label trial, you could go through the scan and randomization and then withdraw if you get an arm you don't want and then do your preferred treatment with your docs. Anecdotal forum posts are fine for some info, but I would go by published study results when choosing, along with my docs' knowledge and experience. Some trials can have many advantages, including drug costs, study visits, scans, tests, etc. Check also for any travel/meal reimbursements
Not all costs are always covered, however: things that are SOC are often not. If you intend to enroll in the trial, make sure you ask to take the Informed Consent Form home to read before signing. They are often very long documents and it's better to read it carefully. Then you are better equipped to ask questions when you go over it with the research nurse, when you will initial each page and sign the last.Metastatic Prostate Cancer: Sorting Through the Treatment Maze
(ASCO Post, 2020)
What I think or would do in your shoes really has no value for your decision making, but I would point out that you have been a good fighter up to now!
Keep us posted and good luck!
Two suggestions if you aren't very familiar with searching the med literature: (1) start with 2020 articles and (2) rely on any recent Review articles you find. When reading a paper, you come across a claim or mention of another study that interests you, use the reference number given and the paper's Reference section to work your way back in time to other papers. Review articles are especially valuable: they do the research for you by finding all the relevant studies, select the meaningful studies pointing out caveats in some study results, and sometimes draw meaningful conclusions. I find that working backwards with the aid of Review articles is the best way to armchair travel