Posted 3/21/2021 10:23 AM (GMT -6)
For the first time in 18 months, my PSA went down, from 43 to 35.2 (18%). I had passed on my 3-month Lupron shot last September as my docs said it simply wasn’t working and that I could stop if I wanted. I’d had Zytiga for 19 months before PSA climb, then Xtandi for 5 months. In the previous 4 months before I stopped Lupron, my PSA went from 3.1 to over 12. One year before, PSA was 0.4.
In October I did three Provenge treatments as PSA continued to climb. This past February, I was interested in LU-177 trials but discovered that my T-level was 67, and most trials required T-level under 50. That’s when I decided to go back to Lupron—except there was something new called Orgovyx. I started Orgovyx Feb 10. On Feb 15 my T-level was <7, and my PSA had jumped from 29.7 to 43, a 45% jump—largest ever.
Then I did labs on March 15, and expected PSA would be close to 60, given the recent trajectory. PSA was 35.2. Yes, that’s only one test—but the change is dramatic. With 30-40% MONTHLY PSA increases the norm this past year, a DROP of any amount is significant. What this tells me is that while you can be deemed castrate resistant, that doesn’t mean your cancer is 100% CRPC. This may be why many docs (including mine) generally recommend you stay on Lupron forever.
As for Orgovyx, before claiming it as some wonder drug, I can tell you I like taking a single pill each day vs a 3-month shot, because I can stop anytime I want or need to. But otherwise, Orgovix has no more SE’s for me than Lupron. May even be slightly less, though fatigue mixed with age is hard to quantify and compare.
It will be interesting to see how long Orgovyx might hold down PSA, but thought you all should know a little about this new Lupron-like drug--that so far for me, is working quite well.