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Pratoman
Forum Moderator
Joined : Nov 2012
Posts : 9454
Posted 8/28/2021 1:20 PM (GMT -8)
I saw that. I think we actually had one horrific day about 10 days ago, where the U.S. had 237,000 new cases.

Its pretty horrific, hopefully the trend down asserts itself.
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Cyclone-ISU
Veteran Member
Joined : Oct 2014
Posts : 3127
Posted 8/28/2021 1:39 PM (GMT -8)

After hearing from Dr. Kwon & his team at Mayo Clinic, recommending I get the corona booster NOW --- I went to a local pharmacy yesterday, and rolled up my sleeve.

I had to fill out a brief questionnaire, and state a medical reason for receiving the booster. Appointments were being accepted --- but "walk ins" were welcomed, as well.

It helps to bring your insurance card and vaccination card, I discovered!

They created a new vaccination card for me, listing the dates of the first two doses and yesterday's booster --- all PFIZER, in my case.

The pharmacy tech said I would be fully "ramped up" in two weeks --- and to stay hydrated after receiving the booster.

They asked me to sit in the waiting area of the pharmacy for 15 minutes, after receiving the vaccine, just as a precaution.

No side effects to report, thankfully!

I always lift a few hand weights in the evenings after receiving a vaccine, and that helps take away upper arm tenderness or soreness, in my case.

An additional motivational factor, for me --- in seeking the booster vaccine yesterday ...

Due to a death in my extended family in recent days, I will now be helping to take care of a immuno-compromised relative of mine who is homebound, this fall.

The pharmacy techs stated they were seeing an uptick in foot traffic at the pharmacy, in recent days --- including those seeking their first corona vaccine dose.

Getting the booster was "on my mind" after hearing from Mayo Clinic. Honestly --- it was easier to just go to the local pharmacy and "get 'r done" --- rather than mulling it over.

Best to each & all!
CYCLONE --- # Iowa State University
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F8
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Joined : Feb 2010
Posts : 5775
Posted 8/28/2021 2:35 PM (GMT -8)

Pratoman said...
I saw that. I think we actually had one horrific day about 10 days ago, where the U.S. had 237,000 new cases.

Its pretty horrific, hopefully the trend down asserts itself.

some of the states don't count every day so that's why i prefer the 7-day average. i don't see a peak but there are signs in some places that we could be near one. the real question is what will happen this fall?
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Cyclone-ISU
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Joined : Oct 2014
Posts : 3127
Posted 8/29/2021 7:42 AM (GMT -8)

Ummm ... well ... how do I "step into" this topic?

Des Moines and many other cities across the United States are now participating in a newer study ----in which samples are drawn from that city's sewage treatment system.

Not a job I would care to have, just sayin' --- but read on!

Why test the sewage, you ask?

The reason being --- scientists find that sewage testing is indicative of what that community is experiencing, in real time, in terms of corona virus spread in that urban area.

Research shows that FUTURE trends --- in terms of corona spread --- can often be predicted by testing sewage samples.

It's believed many cases of corona aren't always known or reported ... but samples from the sewage treatment center DO "tell the tale" ...

The sewage treatment plant samples for the city of Des Moines show traces of corona have increased by nearly 700% within the past month.

YIKES!

Like many other places across the country, area hospitals here are now reaching capacity limits.

The old adage "the proof is in the pudding" might also translate to ... well ... "the proof is in the ... ummm ... well ... SEWAGE" ??!!

A sidenote of interest on this thread topic, I thought!
CYCLONE -- # Iowa State University
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Tudpock18
Forum Moderator
Joined : Sep 2008
Posts : 5433
Posted 8/29/2021 11:36 AM (GMT -8)
As noted, my wife and I got our third jab yesterday. She only experienced a sore arm and was fine this morning. For me it was a little more difficult with the third shot. I had fatigue, headache and low grade fever that lasted about 24 hours. All good now but the third shot kicked my butt a bit. Still worth it as we will be travelling a lot in Sept-Oct so wanted to get boosted up before wandering out into COVID-world.

Jim
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Michael_T
Veteran Member
Joined : Sep 2012
Posts : 4049
Posted 8/29/2021 11:38 AM (GMT -8)
Thanks for taking one for the team, Jim.
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mr bill
Veteran Member
Joined : Sep 2010
Posts : 940
Posted 8/30/2021 6:33 AM (GMT -8)
They are testing the sewage in our town as well. The "honey dippers" seem pretty confident they are able to learn from results. Last year the COVID readings went up when college students came back.
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RCS
Veteran Member
Joined : Dec 2009
Posts : 1351
Posted 8/30/2021 9:15 AM (GMT -8)
Third shot on Sunday. Aches and pains, tired and woke up with ringing ears.
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Tudpock18
Forum Moderator
Joined : Sep 2008
Posts : 5433
Posted 8/30/2021 9:57 AM (GMT -8)

RCS said...
Third shot on Sunday. Aches and pains, tired and woke up with ringing ears.

I predict by tomorrow you will be fine. As shown above, my shot was Saturday. Sunday was a bit ragged but I woke up this morning, played some tennis and worked in the yard. Now I'm gonna check to see if my wife is in the mood...I'll see if this booster has extra powers and will let you know. Actually, can you imagine if that was true? There would be no vaccine hesitancy among males....!

Jim
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RCS
Veteran Member
Joined : Dec 2009
Posts : 1351
Posted 8/31/2021 10:31 AM (GMT -8)
Tud,
I am fine today …. I’d be interested in the results of your “trial” …. I did have a stiff arm😊.
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BillyBob@388
Veteran Member
Joined : Mar 2014
Posts : 4855
Posted 9/13/2021 2:34 PM (GMT -8)
What do Y'all think about these opinions? Yay or Nay?
"18 leading scientists, including 2 outgoing FDA officials, say COVID-19 booster shots lack evidence and shouldn't yet be given to the general public.....................
Business Insider
18 leading scientists, including 2 outgoing FDA officials, say COVID-19 booster shots lack evidence and shouldn't yet be given to the general public
Dr. Catherine Schuster-Bruce
Mon, September 13, 2021, 10:20 AM·3 min read

Eighteen leading experts said "widespread use" of COVID-19 vaccine boosters isn't backed by evidence.

The group included two FDA officials who resigned over the Biden administration's booster shot plan.

Current COVID-19 vaccines still protect against severe illness caused by the Delta variant, they said. ..............

Eighteen top scientists from across the world have warned against giving COVID-19 booster shots to most fully vaccinated people.

In an review published in the Lancet on Monday, the experts said that the idea of boosting immunity to reduce COVID-19 cases was "appealing." But current evidence didn't support "widespread use of booster vaccination" in the general population, they said, citing 93 references.

"Careful and public scrutiny of the evolving data will be needed to assure that decisions about boosting are informed by reliable science more than by politics," the review authors said.

The group included Philip Krause and Marion Gruber, the two Food and Drug Administration officials who resigned over the Biden administration's booster shot plan earlier in September.........................

The group, which included scientists from the US, UK, Mexico, Jamaica, France, Portugal, South Africa, and Colombia, said that there could be a significant risk of side effects if boosters were "widely introduced too soon, or too frequently."

This was especially the case for vaccines with "immune-mediated side-effects," such as a type of heart inflammation, called myocarditis, that has been reported in very rare cases after the second dose of Pfizer or Moderna's vaccines.

The researchers warned that if lots of people got side effects with the extra doses, this could reduce vaccine acceptance.

Dr. Ana-Maria Henao-Restrepo, the lead author of the review and a scientist at the World Health Organization, said in a statement that "even if some gain can ultimately be obtained from boosting," the world should focus on getting shots to unvaccinated people.

The WHO has urged countries with good vaccine coverage to hold off boosters until every country has fully vaccinated at least 10% of its population.

The group said that current vaccine supplies could "save more lives" if they weren't used for boosters.

"Unvaccinated people are still the major drivers of transmission and are themselves at highest risk of serious disease," they said.

Existing COVID-19 vacccines were holding up against newer variants like Delta, the review authors said.

The antibody response for vaccination can decrease over time, but this is just one aspect of the immune response. Other parts of the immune system, such as memory cells and T cells, are often longer-lived, and can also provide protection, they said.

The scientists said that an increasing numbers of breakthrough infections were "inevitable" as more people become fully vaccinated and people's behavior changed.

The study authors did not rule out boosters entirely. Boosters tailored to the variants most likely to evolve could "ultimately be needed."

"Now is the opportunity to study, before there is a widespread need," they said.

Read the original article on Business Insider....................".
https://news.yahoo.com/18-leading-scientists-including-2-142053541.html
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BillyBob@388
Veteran Member
Joined : Mar 2014
Posts : 4855
Posted 9/14/2021 6:29 AM (GMT -8)
Any thoughts on the above linked article about ""18 leading scientists, including 2 outgoing FDA officials, say COVID-19 booster shots lack evidence and shouldn't yet be given to the general public.........."?

Y'all think they know what they are talking about, or rather they are bad wrong?

"..........The group included Philip Krause and Marion Gruber, the two Food and Drug Administration officials who resigned over the Biden administration's booster shot plan earlier in September.........................

The group, which included scientists from the US, UK, Mexico, Jamaica, France, Portugal, South Africa, and Colombia, said that there could be a significant risk of side effects if boosters were "widely introduced too soon, or too frequently."......."
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Michael_T
Veteran Member
Joined : Sep 2012
Posts : 4049
Posted 9/14/2021 7:32 AM (GMT -8)
Re the Lancet article, I also read that over my morning scrambled eggs. There were some interesting thoughts in it. On a personal level, I'm game to wait a bit longer and see what additional info comes in. My second shot of Pfizer was in mid-April, so I'm only five months out. I'm still pretty sure a booster is in my future--just not now.

I did think it was interesting that the Lancet article raised the possibility of a future shot being targeted more toward the current variants out there, as opposed to being a third shot of the original formula. That's certainly the flu shot game plan.
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Vynbal
Regular Member
Joined : Apr 2021
Posts : 95
Posted 9/14/2021 7:47 AM (GMT -8)
Got my 3rd dose of Moderna on Sunday. Sore arm yesterday, well controlled w/alternating Ibuprofen and aspirin. Last night I felt like I do when I take too much Pseudofed - ringing ears, tingling digits, edgy/jittery/wired - unable to relax (which was not a good thing at 1am!)

We were hoping to get to Israel for my eldest grandson's Bar Mitzvah, but Israel changed rules again and only accepts vaccines given in Israel to excuse a mandatory 14-day quarantine.
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Tudpock18
Forum Moderator
Joined : Sep 2008
Posts : 5433
Posted 9/14/2021 12:46 PM (GMT -8)
Re the Lancet article, I think there are two agendas going on which are not unreasonable but are different from what other scientists are thinking. The agendas are, (1) shots should not be "wasted" on rich countries via a booster rather they should be distributed to third world countries first and (2) the current 2 shot regime (1 with J&J) still provides excellent protection against severe disease or death. So even though this regime has flagging effectiveness in preventing one from catching the virus, the purpose of the vaccine is to prevent severe illness/death not to stop people from catching it at all. That is, some level of breakthrough cases are OK.

Though I'll note that the scientists who wrote the article doubt the booster for the general population but don't rule it out for immune compromised or older folks, i.e. most of us.

A contrarian view, e.g. Dr. Fauci seems to counter these points as follows. (1) America First, i.e. we have enough doses for our people to get a third shot and we also provide a lot of free doses to third world countries so the "common good" mainly extends to US residents and (2) a booster shot will provide enhanced prevention from getting the virus at all. The fewer people that get the virus, the fewer that spread the virus and the sooner the pandemic is controlled.

Personally I subscribe to Dr. Fauci's view. I got the booster because I want to be better protected against a breakthrough case and, while I feel for third world countries, that doesn't overcome my selfishness is wanting to take care of myself and fellow countrymen/women first.

Jim
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BillyBob@388
Veteran Member
Joined : Mar 2014
Posts : 4855
Posted 9/14/2021 1:00 PM (GMT -8)

Tudpock18 said...
Re the Lancet article, I think there are two agendas going on which are not unreasonable but are different from what other scientists are thinking. The agendas are, (1) shots should not be "wasted" on rich countries via a booster rather they should be distributed to third world countries first and (2) the current 2 shot regime (1 with J&J) still provides excellent protection against severe disease or death. So even though this regime has flagging effectiveness in preventing one from catching the virus, the purpose of the vaccine is to prevent severe illness/death not to stop people from catching it at all. That is, some level of breakthrough cases are OK.

Though I'll note that the scientists who wrote the article doubt the booster for the general population but don't rule it out for immune compromised or older folks, i.e. most of us.

A contrarian view, e.g. Dr. Fauci seems to counter these points as follows. (1) America First, i.e. we have enough doses for our people to get a third shot and we also provide a lot of free doses to third world countries so the "common good" mainly extends to US residents and (2) a booster shot will provide enhanced prevention from getting the virus at all. The fewer people that get the virus, the fewer that spread the virus and the sooner the pandemic is controlled.

Personally I subscribe to Dr. Fauci's view. I got the booster because I want to be better protected against a breakthrough case and, while I feel for third world countries, that doesn't overcome my selfishness is wanting to take care of myself and fellow countrymen/women first.

Jim

Tudpock, I just started a new thread abot this subject. If it is OK with you, I will copy your response over to that one.
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compiler
Veteran Member
Joined : Nov 2009
Posts : 7710
Posted 9/14/2021 1:12 PM (GMT -8)
Jim:

I agree with you RE: Fauci's points. We shall see how the FDA comes down on this, eventually.
But there is another point that folks are missing. We all agree that the 2-shot vaccination seems to innoculate us against severe illness in terms of hospializations/death. But many breakthrough cases are far from minor. Many of these folks suffer greatly with significant, debilitating, and long-lasting symptoms. it ain't no walk in the park. Heck, we all get flu shots to ward off a much lesser illness.
I had my 2nd shot in late March. I am leaning towards doing the booster in late November, barring new information suggesting otherwise.
Mel
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Michael_T
Veteran Member
Joined : Sep 2012
Posts : 4049
Posted 9/14/2021 1:37 PM (GMT -8)
Some data from Israel--pretty sure they use Pfizer there, but not positive. These are cases per 100K people:

Vaccinated with three doses: 0.28
Vaccinated with two doses: 1.62
Not vaccinated: 6.4

I haven't seen a breakdown that includes age or severity of illness. But it seems that there's a significant difference between the three dose and two dose figures... (And not vaccinated is just sort of crazy...)
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Tudpock18
Forum Moderator
Joined : Sep 2008
Posts : 5433
Posted 9/16/2021 2:30 AM (GMT -8)
Now the fun begins at the FDA. Evidently there is a full blown war between the pro-boost and wait-for-boost forces. The wait-fors say they the two-shot protection against severe illness is still good and that we should use the vaccines on third world countries who have a low vax rate. The pro-boosters point to data that says that a third shot helps prevent getting the virus at all and will shorten the pandemic in the US.

I'm impressed by the following from the Pfizer FDA briefing:

Page 44
A recent Israel MoH study also confirmed that a third (booster) dose of BNT162b2 restored very high levels of protection against COVID-19 even in a period when Delta was the dominant strain.28 The study included 1,144,690 individuals age 60 years and older who were eligible for a booster dose between July 30, 2021 and August 22, 2021.
Individuals who received the booster dose were 11.4-fold (95% CI: 10.0, 12.9) less likely to develop a confirmed infection and 15.5-fold (95% CI: 10.5, 22.8) less likely to develop severe illness compared to those who were previously fully vaccinated but did not receive a booster dose.

Page 49
Overall Benefit/Risk Conclusions: The potential risks and benefits as assessed by the safety profile and by the efficacy and immunogenicity of BNT162b2 demonstrated in the pivotal clinical study are balanced in favor of the potential benefits of adding a booster dose (third dose) to the vaccination schedule. Based on the data summarized in this briefing document and in consultation with CBER, Pfizer/BNT is requesting licensure of a booster dose (third dose) of BNT162b2 administered intramuscularly approximately 6 months after Dose 2 in individuals ≥

So this confirms my bias for getting a booster -- which I did. My guess is that the FDA will approve boosters for 65+ age group, 6-8 months after second shot. We'll see...

Jim
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mattam
Veteran Member
Joined : Aug 2015
Posts : 4125
Posted 9/16/2021 4:34 AM (GMT -8)
I saw yesterday that Moderna's data is suggesting that a booster is needed.
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BillyBob@388
Veteran Member
Joined : Mar 2014
Posts : 4855
Posted 9/16/2021 4:41 AM (GMT -8)
Tudpock18,
Pretty impressive numbers from Israel.
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Tudpock18
Forum Moderator
Joined : Sep 2008
Posts : 5433
Posted 9/16/2021 4:49 AM (GMT -8)

mattam said...
I saw yesterday that Moderna's data is suggesting that a booster is needed.

Yes, but the Moderna submissions are a couple of weeks behind Pfizer. Since the vaccines are similar it's likely that the results will be similar. I previously knew the Israeli Pfizer data and leaned in to the Moderna conclusion when getting my third Moderna shot.

Jim
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steve0
Regular Member
Joined : Dec 2016
Posts : 276
Posted 9/16/2021 4:56 AM (GMT -8)
Well I guess I got the lucky shot.... I got the full dose of Moderna three weeks ago and now they are saying the booster will be a half dose. I guess I am double protected.
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Michael_T
Veteran Member
Joined : Sep 2012
Posts : 4049
Posted 9/16/2021 5:57 AM (GMT -8)
I always ask for a double shot of my baby's love.
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island time
Veteran Member
Joined : Dec 2014
Posts : 2364
Posted 9/16/2021 9:58 AM (GMT -8)
Eligard and Xtandi

A family member is being treated with the above drugs for advanced PCa. Can anyone direct me to information as to whether either of these 2 drugs lower one’s immune system?

Are these drugs biologics? (I don’t think so)
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