What does "predicted PSA" mean and "PSA density"?

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Regular Member

Date Joined Oct 2006
Total Posts : 411
   Posted 11/3/2006 4:52 PM (GMT -6)   
Hi all,
My bf was recently diagnosed with prostate cancer, and we requested the medical records because we can't get in for an in-person counsel until the 9th.
History is had a PSA of 3.7 up from 3.4 year before, Gleason is 3+3, 10 biopsies, one shows 5% cancerous.
Anyway, my question, is in the medical report from the date of biopsy, it says "The prostate is 53 gm in total size. Predicted PSA is 6.3. PSA density is .07."
What exactly is "predicted PSA" and "PSA density."??
I have these on list of questions to ask doctor when we go for consult, but thought someone here could clue me in?

Regular Member

Date Joined Sep 2006
Total Posts : 211
   Posted 11/4/2006 8:09 AM (GMT -6)   

PSA density can be more relevant than the PSA number itself, because a large gland naturally produces more PSA.

The density is calculated by dividing the PSA reading (3.7) by gland size (53) to give the density of .069

Density of less than 1.5 is usually regarded as favourable.

Some research by Johns Hopkins into "insignificant" cancers uses this as one aspect when they discuss stage T1c cancer found in one or two cores, makes up less than half of each core, gleason score is 6 or lower, PSA density is less than .1  - .15  and the free PSA is greater than 15%

Johns Hopkins newsletters are at www.urology.jhu.edu/newsletters

The books by Lee Nelson and by Dr Peter Scardino cover these aspects in more detail.


Regular Member

Date Joined Oct 2006
Total Posts : 411
   Posted 11/4/2006 11:48 AM (GMT -6)   
Thanks for that explanation. 

Signficant Other diagnosed: 10/30/06 (age 63)
PSA: 3.7 (up from 3.4 prior year)
Gleason: 3+3
Biopsy: 1/10 positive, 5% cancerous, right apex.
Treatment:  Undecided

Regular Member

Date Joined Sep 2006
Total Posts : 80
   Posted 11/4/2006 12:37 PM (GMT -6)   

Hi IzzyBlizzy,

That was a good question, I didn't know the answer either.  Thanks to you aus for helping us to understand a little better!

Husband diagnosed May 2006 at age 50.  RRP performed 13 July 06.
PSA 5.7,  Gleason 3+4=7, Staged T2C, Cancer confined to prostate.
His father diagnosed at age 62 and is currently a 13 year survivor!

New Member

Date Joined Nov 2006
Total Posts : 10
   Posted 11/4/2006 3:52 PM (GMT -6)   
Very informative didnt know that factored into it that much
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