Biopsy Opinion

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Veteran Member

Date Joined Sep 2006
Total Posts : 741
   Posted 11/9/2006 1:53 PM (GMT -6)   
This is for those of you who are awaiting and dreading their first biopsy.  I had mine done an hour and a half ago.  The memory is still fresh, so here goes:
After I checked in, a nurse came and got me within 10 minutes.  I gave a urine specimen and then went to an exam room where I waited a few minutes and was then led to the procedure room.  The nurse asked me a few questions to which they had the answers.  She then told me to take off everything below my waist, sit on the table, and cover myself with a paper sheet.
The nurse came back in a bit and had me lie on my left side with my butt at the edge of the table. She then raised the table.  The doc came in and began explaining what they were going to do.  I told him I already knew what to expect and to have at it.  He greased me up and slid the probe in.  It was smaller than I expected.  They sonogramed me for a few minutes (very few) and then gave me the shots.  They pinched a bit, but no worse than that.  He then did 12 samples which took another few minutes and caused absolutely no pain.  None.  Zip.  Zilch.
The only surprise was the blood.  There was blood on the pad I lay on and some bright shiny blood dripped from my penis.  I wiped a bunch of blood from my backside, too.  I told the doc and he was not concerned.  I had to change my underwear when I got home - soaked through my pants in front, too.  It aches a bit down there, so I have taken a couple of tylenol and it's better.  Not much blood now, either.
Beats the hell out of finding cancer when it's too late.  It was an unpleasant experience and I hated every minute of it.  I'd do it again in a heartbeat if it caught cancer in its early stage.  I hope this helps some of you guys.  I'm a real weenie about medical stuff and this was tolerable.
I think I'll take my bride, my daughter, and my new grandson to lunch.
Today is much later than this original post.  As you know, I did/do have cancer.  I'm sending this to the top in case there are other guys (like bobbailey) who have not yet experienced their biopsy.  I sure wish I had known what to expect.  My blood pressure would have been about a thousand points lower. 
There was blood in my urine for just a few hours and blood in my ejaculate for weeks.  It was bright, shiny red blood for a few days.  Not fun.  My uro said I could have bloody ejaculate for up to three months. 

Gleason 3+3=6, T1c, one core in twelve, another pre-cancerous.
62 years old and good health.  Married 37 years.  To same woman!
Began IGRT January 23, 2007. 

Post Edited (jetguy) : 3/11/2007 7:53:21 AM (GMT-6)

Regular Member

Date Joined Aug 2006
Total Posts : 148
   Posted 11/9/2006 3:44 PM (GMT -6)   
Familiar experience to many of us. Hope that's the worst you have to endure. I'm hoping it's all negative. Good luck!

Diagnosed 8/24/06
Gleason 6
PSA 3.32
stage T1C
age 48
daVinci on 10/20/06

Veteran Member

Date Joined Apr 2006
Total Posts : 818
   Posted 11/9/2006 4:23 PM (GMT -6)   

Hi jetguy,

Yep, Brings back old memories, but as you said if it brings in an early diagnosis than it certainly was worth the 15 minutes of discomfort. Good luck; I hope the results are better than you expect.



Diagnosed at age 60
PSA went from 2.2 to 3.8 in 14 months
2 ot 14 cores positive at 10%
Gleason 6(3+3), negative DRE, neg. boundaries
DaVinci surgery on 02/23/06

Veteran Member

Date Joined Oct 2006
Total Posts : 626
   Posted 11/9/2006 4:29 PM (GMT -6)   
Hi Jet,

Yea, that is about the way it was for me also. I did not have any bleeding from the biopsy. You will find that the blood in your semen will last for several weeks. As you said it is a small sacrifice to pay for the early detection of PCa.

Diagnosed 7/6/06
1 of 10 core samples, 40%
Stage T1c, Gleason 3+3
Da Vinci on 11/01/06
56 Years Old

Regular Member

Date Joined Nov 2006
Total Posts : 56
   Posted 11/9/2006 5:37 PM (GMT -6)   
Hi Bill, must apologise, you put a reply on my page ( Mickeyboys page ) and i clicked on some icon and you disappeared, still not used to forum yet. Anyway more important how did you get on with biopsy, hope it all went well, ive had 3 of them 12, 16, 12 samples over 18 months, not the nicest of things to have done but bearable, lets face it my friend the sooner they find out if anythings wrong the sooner they can sort it, unfortunately the last 1 not so good
found something suspicious and diagnosed Gleason 3+3 a couple of weeks ago, having surgery on 8 Dec, not something i expected to go through at my age
( 48 ) but my dad diagnosed about 62 and ive been checked every year since i was 40, he didnt die from it though he died from something else at 70.
In reply to your post i live in an area about 8 miles from the centre of london just on the outskirts, lots of people leaving our once great country due to the influx of all the east european immigrants, they are gradually taking over, especially in the building trade. But me no its in my blood and lets face it somebodys got to stay and look after it, family all set up here wouldnt be fair to ask them to move, but if the kids wanted to go i wouldnt stop them at least they would be able to afford to buy a property somewhere like America,Canada.
Anyway nice to talk to you, let me know how you get on and i will catch up with you soon.
All the best
Mike ( London )

Veteran Member

Date Joined Sep 2006
Total Posts : 741
   Posted 11/9/2006 7:29 PM (GMT -6)   

Incredible.  No blood in the urine seven hours post biopsy.  Don't know about the other side and don't much care.  The ache down there is gone.  I hope that you are as lucky as I.



M. Kat
Veteran Member

Date Joined Jul 2006
Total Posts : 715
   Posted 11/9/2006 9:01 PM (GMT -6)   
Bill, I'm glad that's over and now to wait for the results. Jeff said it wasn't too bad, not something he'd elect to do, but a necessary evil. He had quite a bit of blood in his semen so don't be surprised if that happens.
Husband Jeff 56 years old
diagnosed July 27, 2006
PSA 6.5
2 positive areas in biopsy, Gleason 3+3=6
Radical Retropubic Prostatectomy August 30, 2006
pathology report - all clear - cancer gone
1st post-surgery PSA test 0.1
no more pads Oct 12, 2006

Tim G
Veteran Member

Date Joined Jul 2006
Total Posts : 2361
   Posted 11/9/2006 11:07 PM (GMT -6)   
Welcome, JetGuy--
I had the dozen biopsies too, and found the anticipation was the worst part.  Not bad really.   I hope it's benign, but if it's not, you're among friends here.  I wish you well!  Take care and hang in there!

Age 58  Open Nerve-sparing prostatectomy 6/21/06  Cancer confined to prostate  3-month PSA non-detectable

Veteran Member

Date Joined Sep 2006
Total Posts : 741
   Posted 2/14/2007 7:54 PM (GMT -6)   
I just read where one of us had his biopsy today, so I'm sending this to the top in case there are others lurking and dreading their biopsy. It's survivable and in my case it found cancer early and treatable. It's my understanding that some guys refuse the biopsy and later suffer the consequences. I was almost there.



Gleason 3+3=6, T1c, one core in twelve, another pre-cancerous.
62 years old and good health.  Married 37 years.  To same woman!

Regular Member

Date Joined Oct 2006
Total Posts : 444
   Posted 2/14/2007 8:11 PM (GMT -6)   
jetguy and everyone else!

i am reposting here the biopsy portion of my thread entitled "Proton Therapy--My Journey With Prostate Cancer" to vividly support what jetguy is saying. DON'T MAKE THE MISTAKE I MADE OF AVOIDING THE BIOPSY FOR OVER THREE YEARS UNTIL MY PSA GOT TO THE POINT WHERE I PANICKED.

*****My Prostate Biopsy

I had a 29-core biopsy on September 27, 2006! I must confess that there was not much discomfort. A sedative was injected into my prostate (a little pin prick through my rectal wall into the prostate—then you could feel the sensation of the serum being injected). Then it was 29 clicks and we were done. So don’t be fearful of a biopsy—make sure that your urologist performing the procedure gives you some kind of sedation in your prostate beforehand. I was surprised at the number of samples taken, but it gives me greater assurance of my stage of cancer. If you have a biopsy, don’t settle for less than 12 samples; a minimum of 20 would be preferable. Having too few biopsy samples may not give you the best indication of your stage of prostate cancer which is critically important in selecting your treatment.

*****My Big Mistake—Don’t Be Afraid of a Prostate Biopsy

Over three years before my biopsy, my internist recommended to me to get a biopsy when my PSA jumped up to a little over 5. I didn’t like the thought of a biopsy and didn’t follow through. I then avoided a physical for over two more years, at which time my PSA had jumped to over 8. At that time I panicked and quickly decided on getting a biopsy. I am still lucky to be in an earlier stage of prostate cancer, but I obviously would have been in a much earlier stage if I had taken my doctor’s advice. I am lucky that my prostate cancer appears to be slow growing.

68, Biopsy 9/27/06, Stage T1c, PSA 7.1, Gleason 6 [less than 5% in two areas], Gleason 7 (3+4) [less than 20% in third area], negative DRE, bone scan and MRI. Starting proton radiation therapy 2/22/07.

Regular Member

Date Joined Feb 2007
Total Posts : 242
   Posted 2/14/2007 10:59 PM (GMT -6)   
Not all biopsy's are done that way. My husband was checked into the outpatient surgery part of our local hospital. The worst part was the 2 hour delay we had. He was knocked out for the entire procedure (21 cores). He does not remember any of it. As a matter of fact, after waiting one hour past scheduled time, he was ready to walk out and get a second opinion before having the biopsy. We came home that evening. The biopsy is not the worst part. Finding the cancer early is the best part possible.
Kurt & Courtney
47 year old
Great Health prior to dx
Dx on 1/29/07
PSA 4.1
Gleason 3+3=6, both lobes
Stage T2c, I believe
Tumor involves 20% of cores, both lobes
Live in OK
Da Vinci scheduled 3-15-07 in Austin

Veteran Member

Date Joined Sep 2006
Total Posts : 741
   Posted 3/11/2007 8:55 AM (GMT -6)   
I'm sending this to the top for Walt and any other poor soul who is dreading the experience.

Gleason 3+3=6, T1c, one core in twelve, another pre-cancerous.
62 years old and good health.  Married 37 years.  To same woman!
Began IGRT January 23, 2007. 

B&B's World
Regular Member

Date Joined Mar 2007
Total Posts : 120
   Posted 3/11/2007 12:42 PM (GMT -6)   
B's Biopsy:

Accepting the urologist's recommendation for a biopsy was difficult. There was a lot of worry about pain, especially after the biopsy. We put it off for a month, because we had the trip of a lifetime planned, and didn't want to know until after. But, the whole idea of it was very difficult. B suffers from anxiety in general, and due to this asked his primary care physician about the possibility of receiving some anti-anxiety medication right before the procedure. He directed him to the urologist, saying it was a reasonable request. The urologist's office said that the doctor would administer an IV valium, but that B would have to have someone drive him to the appointment. No problem, I drove him there. After waiting a long time in the waiting room, he was ushered into a cubicle. Nothing was administered, and he waited for 20 minutes looking at what he deemed "instruments of torture", long needles and a "***" shaped instrument, while I waited in the waiting room. He said it was all he could do to keep from walking out of there! When the urologist came in, B asked when he would receive the anti-anxiety meds, and the doctor replied, "You don't need it" B said, "But I specifically asked to have it" Doctor said, "If you insist, but you don't need it. I have already done two of these today and they didn't need it." Angry, B shut down and went through the procedure which, he reported, was uncomfortable but not terribly painful. The worst part was the anxiety leading up to it. Needless to say, B was very angry at the doctor. The incident further exemplified the lack of communication between staff and doctor in this urology group. One week later, after waiting 45 minutes in another cubicle, the doctor came in without even having previously read the report, sit there for 3 minutes and then pronounced, "Well, you have a little cancer" We stumbled out to the desk to make another appointment for a consult after the prescribed blood work, and the young woman couldn't even get B's name right. That did it, we found another urologist after he had the blood work. Our lesson from this was: be pro-active, speak up, find support, find comfort, don't settle for second rate.


Veteran Member

Date Joined Nov 2006
Total Posts : 1464
   Posted 3/11/2007 2:05 PM (GMT -6)   
Wow Becky!

I would have been outta there too. Medical "care-givers" that obviously don't care about the patients anxiety need attitude-adjustment. They do so many of these procedures that they become routine and the medic forgets that this is our first experience. (or just doesn't care) In either case it is time for a change of urologist. Good for you.

During my first biopsy, the doc didn't give me anything to calm the anxiety. It didn't hurt at all but just having somebody messing around "back there" gave me the willys. He said he understood and that no man likes to have that experience. He gave me a valium pill to take a couple of hours before the next biopsy and that made it go a lot easier. (I had two because the first was not conclusive.)

I felt like a wuss having to take valium for the procedure. But everything about prostate cancer attacks our manhood. Being macho and bulletproof soon has to be put aside during treatment. Not being able to hold our pee and not being able to raise a boner (both hopefully temporary) are experiences that no man relishes.

But, like our friend Pete says, "It beats a dirt hole."

Good luck...

Age 72. Diagnosed 11/03/06. PSA 7.05. Stage T2B Gleason 3+3.
RRP 12/7/06. Nerves and nodes okay.
Pathological stage: T2B. Gleason 3+4. Cancer confined to prostate.
PSA on 1/3/07 - 0.04.  Next PSA on 4/4/07.
 "Cancer feeds on fear - starve it to death."

Pete trips again!
Veteran Member

Date Joined Nov 2006
Total Posts : 1899
   Posted 3/12/2007 10:54 AM (GMT -6)   
It sure does Jim!!!
53 years old, Surgury, Radical Prostatectomy 8/20/03, PSA 6.6, Gleason 3 + 3 = 6, Adenocarcinoma extent (moderate) Stage & Margin:T2NOMX, No Metastases, Organ Confined, bone scan: Neg.  

Veteran Member

Date Joined Oct 2006
Total Posts : 626
   Posted 3/12/2007 11:21 AM (GMT -6)   

The local urologists that my primary care provider referred me to did give me a prescription for valium to be taken 30 minutes prior to my appointment. I felt it hit aboput the time that I got there but it was 30 minutes later before they called me back for the procedure. By that time the valium was wearing off. As most men have reported here on this forum the biopsy was not all that bad. But my urologist did the same thing to me that happened to you when I went back to get the report. I did not take my wife with me as he had told us the week before after the biopsy that he did not see anything with the ultrasound and felt that the results would come back negative for cancer. When he walked he opened the door to the exam room to walk in I saw his nurse hand him the chart and a book. He walked in and said that he had not had a chance to look at the results so we would do that together. After about a minute he looks at me and says that 1 of the 10 core samples came back with cancer. Then he proceeded to discuss treatment options which I heard little of since I was reeling from the news. He was pushing the open procedure because that is what he does and I quickly told him that I wanted a second opinion from a university based medical center. Once I left his office I never went back.

Diagnosed 7/6/06
1 of 10 core samples, 40%
Stage T1c, Gleason 3+3
Da Vinci on 11/01/06
Catheter out on 11/13/06
56 Years Old
Post Op Path
Gleason 3+3
Approx. 5% of prostate involved
Prostate Confined, margins clear
Undetectable PSA on 12/18/06
No more pads as of 1/13/07

Veteran Member

Date Joined Jul 2006
Total Posts : 686
   Posted 3/12/2007 6:50 PM (GMT -6)   

My biopsy was a no brainer.  I was anxious (as usual).  Went to a brand new outpatient surgical center.  I had a valium by IV. Drifted off, woke up, went home (wife drove).  Obviously the procedure was painless.  No blood at all.  Next day noticed a little blood in my stool.  ejaculate had a brown tinge for about three times.  None in my urine.  No pain, no complications. 

 I was concerned because good friend got E coli infection (5 days hospital) at Kaiser just weeks before. He was negative for cancer.  He says to me later what do you want a sloppy biopsy with E coli bacteria or cancer.  Ok, if I had my choice I would take the E coli.  I did'nt have a choice.  (Da Vinci January 2007).

Post not edited ~ bottom had white blank area and this was cleared!!! 

Post Edited By Moderator (bluebird) : 7/19/2007 8:36:28 AM (GMT-6)

Regular Member

Date Joined Apr 2007
Total Posts : 171
   Posted 10/16/2007 4:11 AM (GMT -6)   

I have a quick question :-) Was it the urologist's idea to
put your husband in the hospital and do the biopsy under
general anesthesia or did your husband request having it
done that way?

Thank you,

Tony Crispino
Veteran Member

Date Joined Dec 2006
Total Posts : 8128
   Posted 10/16/2007 1:36 PM (GMT -6)   
Hi Wiggyann,
Kziz is not as frequent a visitor, as that post is old. But I think I can hit on it. Sometimes a person feels uncomfortable being awake through the procedure. I considered it and talked to my urologist about it. He told me that 95% get through it fine without general anesthesia. But some have had the colonoscopy by this age and it is much easier to tolerate at least from the perspective of the procedure and not the lasting effects of general anesthesia. Having done both, I would rather just grin and bear it versus checking into a hospital and all the fun things that entails. i tolerated it very well with some bleeding only during ejaculation. One thing you should not. Whether or not you do the procedure with local or general anesthesia, you still have the same side effects from the biopsy. And the discomfort is still present when you are awakened. When kziz was a regular here, I don't recall her posting who's idea it was. For me I was awake for the whole thing, and would have done it that way again.

Age 45 (44 when Dx)
Pre-op PSA was 19.8
Surgery on Feb 16, 2007
Post-Op Pathology was poor: Gleason 4+3=7, 4 positive margins, Stage pT3b (Stage III)
HT began in May, '07 with Lupron and Casodex 50mg
IMRT radiation for 38 Treatments ending August 3, '07
My PSA did drop out after surgery to undetectable.  It has not returned and I will continue HT until January '08.
My Life is supported very well by family and friends like you all.

Regular Member

Date Joined Jun 2007
Total Posts : 176
   Posted 10/16/2007 11:38 PM (GMT -6)   
OK, and a post from one not so brave as Tony. I loved that I was out and don't recall a thing. It was my request and I have no regrets other than the fact that they should have put me out in the pre-op setting like they did for the big surgery and then I wouldn't have had to remember them all chatting around me as they positioned me for the biopsy.
42 yo.
PSA 4.65
Gleason scores from 4 pathologies of the same biopsy with 2 of 12 cores positive for cancer (if this isn't confusing to the patient...):
1) both cores 3+4 (Weiss Memorial)
2) one 3+4 and one 3+3 (Univ. of Chicago Hosp.)
3) both cores 3+3 (Mass General Hosp.)
4) both cores 3+4 (Northwestern Memorial Hosp.)
9/17/07 - Radical Retropubic Prostatectomy Surgery at Northwestern Memorial in Chicago by Dr. William Catalona.
and the winner op Gleason score of 3+4.
Good pathology report with negative margins, no seminal vesicale involvement, no lymphatic or vascular invasion, bladder and urethral free and tumor volume was 5% of 27.3g.  Amazing how something so small can cause such problems!
9/27/07 - Catheter removal...let the games begin...

Regular Member

Date Joined Sep 2007
Total Posts : 219
   Posted 10/17/2007 7:05 AM (GMT -6)   


It's like everything else involved with this monster. Everyone have different experiences. Mine was very uncomfortable (hurt like he**), but this was due to how hard the surface of my prostate was. I was very concerned sitting in the room with a paper towel covering me up, looking at the needles and what appeared to be a small version of a "Los Angles Class Nuclear Attack Submarine" that was about to dive to the depths of my inner world and start firing missiles. The battle is always in our heads.

A close friend of mine has had the proceedure three time now and has "cracked" jokes with the doc and nurse all three times. Something about him and the doc "going steading".

The only real advise I have is to tell the doc to let you know when he is about to "fire" each needle. I almost came off the table when the first one went off. Sounded like a .22 being fired. After that the doc gave me some warning and everything went fine.

Everything will be fine.

Keeping all of you in our prayers and a big War Eagle to all.


Age: 54
PSA 43 7/2005
Biopsy 12/14 Gleason 7 & 9
Divinci 9/2005 - spread to bladder
HT - 10/2005 (Eligard every 6 months)
RT - 10/2005 (38 treatments)
PSA 0.12 to 1.9 2/2007
Bone Scan and CT 4/2007
Casodex 4/2007
Spread to Spine (L4 & T5), rib, and pelvis
Zometa infusions 4/2007
PSA 4.8 8/2007
PSA 4.9 9/2007
PSA 5.4 10/07
"I will persist without exception - I will find a way where there is no way"

New Member

Date Joined Oct 2007
Total Posts : 5
   Posted 10/18/2007 3:40 PM (GMT -6)   

Here's a new one.  I had a Biopsy about a month ago.  Results came back from a large lab indicating a gleason score 3+3=6, 5% of the biosy issue on one side.  My urologist, thankfully, send the sides to another pathologist in a nearby hospital.  According my urologist, the 2nd pathologist is very experienced in the field of prostate cancer.   The results came back negative for cancer.  Now, my urologist recommends another biospy in a couple of months.  However, this time he wants to do an saturation biospy taking 12 samples all on side of the prostate.  Has this happened to anyone? 



Age: 43

PSA 3.6-3.7

Free PSA 31%


Veteran Member

Date Joined Nov 2006
Total Posts : 1464
   Posted 10/18/2007 4:29 PM (GMT -6)   
Hello Nini,

I had the same experience. The first biopsy came back inconclusive so my uro had me do another one in a month. It was positive.

Its good that he got a second reading. Second opinions are always good no matter what stage of diagnosis and treatment we are in. Its just one way that we take control over our own treatment.

Here's hoping the next one is negative too.

Age 73. Diagnosed 11/03/06. PSA 7.05. Stage T2C Gleason 3+3.
RRP 12/7/06. Nerves and nodes okay.
Pathological stage: T2C. Gleason 3+4. Cancer confined to prostate.
PSAs from  1/3/07 - 10/17/07 0.00. 
T level on 4/2/07 - 48     On 7/16/07 - 613
Started Tri-Mix on 8/7/07.  .02 ml and 50 mg Viagra.  It works!!!
Next PSA and T tests on 1/15/08
"Patience is essential, attitude is everything."

Regular Member

Date Joined Aug 2007
Total Posts : 120
   Posted 10/18/2007 5:05 PM (GMT -6)   
I probably should have gotten a second opinion, however it would have only changed the Gleason score as the cancer was surely there. The Gleason did change when the path report came back after surgery. I was a little shook up when the cancer was closer to 8 than 6 as I had thought. It also was necessary for the surgeon to remove more than originally figured on. All in the past now on to recovery. Uncle Dan
Age 67
No symptoms, DRE negative
10 - 06 PSA 5.44, 01 - 07 PSA 6.47
5 - 07 CT and Bone scans negative
05 - 07 Biopsies, 2 of 6 positive
Gleason Score (3+4) 7 Stage T1c
08 - 14 Dr. Dasari - Baptist Hospital, Nashville
da Vinci RAP, five hours surgery
Some right nerve and all left nerve removed,
Hospital discharged 8 - 16
Pathology report Negative margins
Encapsulated, 50% left side
Lymph nodes 2 R & 1 L - Negative
R & L seminal vesicles - Negative
Gleason changed (4+3) 7 closer to 8 than 6
9 - 26 Great PSA 0.000
9 - 27 Starting on meds for ED
9 - 30 Dry, 2nd day without pad
Viagra no help yet

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