Perineural Invasion

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Ken S
Regular Member


Date Joined Nov 2006
Total Posts : 120
   Posted 11/16/2006 5:53 PM (GMT -7)   
Hi All,

I had a RP 11/3 and had the catheter taken out yesterday. My doctor told me the patholigist's biopsy report looked good but he was a little concerned about the perineual invasion being positive. Stage T2c and my Gleason score was 6 (3+3) and my PSA was 3.7 , I'm 54. With the initial biopsy he said with my Gleason score and my PSA that this was just a garden variety PC. Now I'm not so sure. This seemed to come out of left field, with all my research on the internet before hand I didn't read anything about this. Anyone out there have a similar experiance and what am I to expect?

Ken S

Letty
Regular Member


Date Joined Sep 2006
Total Posts : 80
   Posted 11/16/2006 7:05 PM (GMT -7)   

Hi Ken and welcome to the board,

We had a very similar situation as yours.  We went back in to have the cath removed and go over the pathology report.  The doctor told us all the margins were clear and that "you'll just have to find something else to die from"!  You can imagine how elated we were.  I asked for a copy of the pathology report for our records. 

After we got home and I was going over it, I read:  Perineural invasion yes, focally identified. 

We were also concerned about this.  When we went back in four weeks later, I was going to ask our doctor what exactly that meant.  Unfortunately, he was called out on an emergency but his associate came in to see us instead so we asked him.  He told us that it meant there was cancer around the nerve but that there was a controversy among doctors about what this meant.  He said that one side believes that because pc can only travel through blood cells, it couldn't travel through the nerves.  The other side believes it can. 

I don't know what to think!  If we believe our doctor, who is very good, the best in the state, (our primary physician called him the "guru" of prostat cancer and he came very highly recommended on several fronts), then we are good to go.

We would also be interested in what others know about this.


Letty,
 
Husband diagnosed May 2006 at age 50.  RRP performed 13 July 06.
PSA 5.7,  Gleason 3+4=7, Staged T2C, Cancer confined to prostate.
His father diagnosed at age 62 and is currently a 13 year survivor!


aus
Regular Member


Date Joined Sep 2006
Total Posts : 211
   Posted 11/17/2006 4:15 AM (GMT -7)   
In his book, Lee Nelson discussed PNI and two studies which showd that "PNI does not significantly increase the risks of recurrence"

LovingWife
Regular Member


Date Joined Jun 2006
Total Posts : 32
   Posted 11/18/2006 8:25 PM (GMT -7)   
We asked my hubby's doc about it. He said the prostate is full of little nerves, like a maze, so PNI doesn't mean it's headed on it's way out necessarily. He told us it's mentioned on a pathology report because it's something they can see, but that it's not worth worrying about since his margins were free. 
 
Good luck with your recovery.
:) LW
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