Pathology Report Questions

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Regular Member

Date Joined Nov 2005
Total Posts : 154
   Posted 5/3/2007 4:06 PM (GMT -6)   
Hi Everyone,
I have some pathology report questions, what does the following mean:
1.  Perineural Invasion Identified
2.  High Grade Prostatic Intraepithelial Neoplasin Identitified
3.  Margin, Left Neurovascular bundle biopsy is mentioned in the report and the Right is not
What follow-up tests are typically done post surgery?
Thank you.
Big Hugs,

Regular Member

Date Joined Nov 2005
Total Posts : 154
   Posted 5/3/2007 5:28 PM (GMT -6)   
One more question, what is the long term impact on having 6 lymph nodes removed?

Thank you again!


Elite Member

Date Joined Apr 2007
Total Posts : 32602
   Posted 5/4/2007 8:30 PM (GMT -6)   


This is Kitt and I will try to answer your quetions however your physician and some wiser member than I may have the best answers for you. :-)

perineural invasion (PNI): PC invading the nerve sheath surrounding the nerves that enter the prostate

PIN or Prostatic Intraepithelial Neoplasia

PIN is graded from the lowest grade (Grade I) with the least changes to the highest grade (Grade III) with the most severe changes. Most medical papers categorize PIN as either high grade or low grade. High grade PIN and Grade III PIN are used synonomously. PC is associated more with high grade PIN than low grade. PIN appears to predate the appearance of PC by more than 5 years.

Neurovascular bundle biopsy

neurovascular bundles: two bundles of nerves between the prostate and the rectum that control erection.  IMO I would like you to visit with your oncologist re this result too.

AEG, I do not have the answer for the impact of the 6  lymph nodes and the diease process is based on many factors. 

You have the right as a patient to speak with the pathologist to have he/she explain the results to you as well as talking to your physician.

Gentle Hugs to you.

RN CCRN, Critical Care and Emergency Department Manager for 26 years.
Depression 25 years, Husband Crohns Disease 30 years
My Father and 5 siblings all died of Cancer. It is a subject close to my heart to help people with Cancer.
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Veteran Member

Date Joined Apr 2006
Total Posts : 1732
   Posted 5/5/2007 10:53 AM (GMT -6)   

There shouldn't be much of a problem at all with 6 node removed. We have so many in the pelvis. If there were a problem it would be in the way of reduced lymph drainage.....leg swelling.

Follow up is managing side effects and monitoring your PSA. Some Doc's still do DREs and some believe there is no need with a negative PSA. Unless there is a rise in your PSA, no further treatment is necessary.

Take Care, Swim
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