Free PSA. What does it mean ?

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KenW
Regular Member


Date Joined Mar 2007
Total Posts : 74
   Posted 6/7/2007 6:05 PM (GMT -7)   
I just had my PSA check and have a psa of 2.19 which is up a bit, but this time There is a free psa # of .33. can anyone explain what the free psa denotes?
Diagnosed with a Gleason 4X3. Second opinion at Stanford came back as 3X4, 1 out of 7 samples, Left Side. DRE showed Normal. Before Biopsy Psa gradually crept to 10. Dropped to 6.4 with Alt. suppliments.
Proton Beam Therapy at Loma Linda 11-06. 1st PSA 4 Months 3.4, PSA at 8 Mo. 1.7. - 1 Yr. PSA 1.8 ( Different Lab ) Awaiting 3rd PSA taken yesterday.


bluebird
Veteran Member


Date Joined May 2006
Total Posts : 2542
   Posted 6/7/2007 7:47 PM (GMT -7)   

Hi ~ Ken W,

Thought I’d reply with the info below.  When I went to post…. your question had changed a little.

Any and all info is important…. So I will send this on…I hope this helps. 

In Friendship ~ Lee

 

 

Excerpt from:

“Dr. Peter Scardino's Prostate Book

Peter T. Scardino, M.D.

Chairman of the Department of Urology ant Memorial Sloan-Kettering Cancer Center and Judith Kelman

 

 

PSA comes in several varieties.  Complex PSA circulates with a companion protein. Free PSA is a sort of bachelor antigen that travels on its own.  This unbound form of PSA comes from BPH, not prostate cancer.

          The widely available test for free PSA (%fPSA) indicates what percentage of your total PSA comes from benign enlargement of the gland.  From this, we can predict the likelihood that a man with an elevated PSA would be found to have prostate cancer if we performed a biopsy.  The test is especially useful for men whose PSA falls between 4 and 10, a gray area where either BPH or prostate cancer might be responsible for the increase.  Testing for free PSA improves our ability to predict whether cancer is the cause of an elevated PSA by 20 to 40 percent yet reduces by only about 5 percent the cancers we would otherwise fail to detect.  The measure can also be useful in characterizing a cancer after it has been diagnosed.

          Reading over 25 percent suggest that the elevated PSA is largely caused by BPH.  Any cancer present is more likely to be small and confined to the gland.  On the other hand, having a free PSA under 10 percent suggests that your total PSA is mostly elevated by a cancer, which is likely to be large and require active, aggressive treatment. 22  Levels between 10 and 25 percent are harder to evaluate in terms of your outlook for a permanent cure.  But, in general, the lower the free PSA, the greater the cause for concern.

 

There is a table/graph on page 145

BPH (benign prostatic hyperplasia)

FootNote Chapter 8

22   Catalona W, Partin A, Slawin K, Brawer M, Flanigan R, Patel A, Richie J, deKernion J, Walsh P, Scardino P, Lange P, Subong E, Parson R, Gasior G, Loveland K, Southwick P (1998). "Use of the percentage of free prostate-specific antigen to enhance differentiation of prostate cancer from benign prostatic disease: a prospective multicenter clinical trial.". JAMA 279 (19): 1542-7.

 

Link to: Prostate specific antigen


mama bluebird - Lee & Buddy… from North Carolina

J  We invite you to visit our personal thread:  Click Here:  “Our Journey” ~ Sharing is Caring 

April 3, 2006  53 on surgery day

RRP / Radical Retropubic Prostatectomy with "wide excision"

PSA 4.6   Gleason  3+3=6    T2a   Confined to Prostate

2nd PSA 02-06-2007 Less than 0.1 Non-Detectable :)


KenW
Regular Member


Date Joined Mar 2007
Total Posts : 74
   Posted 6/7/2007 8:47 PM (GMT -7)   
Lee,
Thanks for the info. I do and have had BPH for a long time, so that info is helpful to know.
 
My post has not changed so not quite sure ???
 
Ken
Diagnosed with a Gleason 4X3. Second opinion at Stanford came back as 3X4, 1 out of 7 samples, Left Side. DRE showed Normal. Before Biopsy Psa gradually crept to 10. Dropped to 6.4 with Alt. suppliments.
Proton Beam Therapy at Loma Linda 11-06. 1st PSA 4 Months 3.4, PSA at 8 Mo. 1.7. - 1 Yr. PSA 1.8 ( Different Lab ) Awaiting 3rd PSA taken yesterday.


bluebird
Veteran Member


Date Joined May 2006
Total Posts : 2542
   Posted 6/7/2007 11:38 PM (GMT -7)   
Hey Ken...
 
My bad...  tongue
I saw your thread Free PSA.  What does it mean?
And I immediately reached for my book and started typing.
Then when I went to post I saw your information and I thought ~ hmmm I don't remember reading this... hmmmm 
 
My mind was so focused on getting some info to you!! I'm glad it helped... thanks for your reply back.
 
Take care and know we are keeping you close in thoughts and prayers...
In Friendship ~ Lee & Buddy
 
 
 
 
 
 

bluebird
Veteran Member


Date Joined May 2006
Total Posts : 2542
   Posted 6/13/2007 4:49 PM (GMT -7)   

Hey ~ Ken,

 

??  Awaiting 3rd PSA taken yesterday.

Saw this in your posting on 6-7 in your signature line…and wasn’t sure if it is current…. Since 3 scores are showing... 

If it is …..this little note is letting you know we are Thinking of You:-)

Waiting for the next PSA is hard… and we wanted you to know that our thoughts and prayers are surrounding you at this time.

 

If it’s not a current PSA… when is your next one? 

 

This message still stands… We are thinking of you and keeping you close. yeah Hope to hear from you soon!  In Friendship ~ Lee & Buddy


KenW
Regular Member


Date Joined Mar 2007
Total Posts : 74
   Posted 6/13/2007 6:17 PM (GMT -7)   

Lee,

The 2.19 PSA I posted above is my newest that I was waiting for.

Seeing my NEW, "Proton Friendy", Urologist in a few days and see how " Friendly" :-) he is and what he thinks of my numbers.

Ken


Diagnosed with a Gleason 4X3. Second opinion at Stanford came back as 3X4, 1 out of 7 samples, Left Side. DRE showed Normal. Before Biopsy Psa gradually crept to 10. Dropped to 6.4 with Alt. suppliments.
Proton Beam Therapy at Loma Linda 11-06. 1st PSA 4 Months 3.4, PSA at 8 Mo. 1.7. - 1 Yr. PSA 1.8 ( Different Lab ) Awaiting 3rd PSA taken yesterday.

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