Is it possible to have a positive DRE exam and not have PC?

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Regular Member

Date Joined Nov 2005
Total Posts : 154
   Posted 6/12/2007 8:18 AM (GMT -6)   
Is it possible to have a positive DRE exam and not have PC?  If a Urologist feels a nodule, is it most likely PC?

Veteran Member

Date Joined May 2006
Total Posts : 2542
   Posted 6/12/2007 2:14 PM (GMT -6)   

Hi ~ AEG,

I hope this helps!  ~ Lee



Excerpt from: “Dr. Peter Scardino's Prostate Book” 2006

Peter T. Scardino, M.D.

Chairman of the Department of Urology ant Memorial Sloan-Kettering Cancer Center and

Judith Kelman

Chapter 9 Page 150


The results of a digital rectal exam (DRE) are highly subjective.  The same thing one doctor finds suspicious might be entirely overlooked or deemed insignificant by a different examiner.  Tiny lumps or bulges may represent meaningless calcifications or benign enlargement of the glad.  Only one in five abnormal DRE’s turns out to be cancer.3


3 Catalona WJ, Richie JP, Ahmann FR, Hudson MA, et al: Comparison of digital rectal examination and serum prostate specific antigen in the early detection of prostate cancer: results of a multicenter clinical trial of 6,630 men. J Urol 1994; 1283-1290.


I found this link …but the percentage shows 1 in 4



Excerpt from “Dr. Patrick Walsh’s Guide to Surviving Prostate Cancer”…(Give Yourself a Second Opinion) 2001

Patrick C. Walsh, M.D.

Professor of Urology, The Johns Hopkins Medical Institutions and

Janet Farrar Worthington

Chapter 5 Page 111

PSA is prostate-specific, not cancer-specific.  This is why a blood test alone isn’t enough, why a digital rectal exam is also a must.  You can have prostate cancer and still have a low PSA level.  And, just because you have a high PSA does not necessarily mean you have prostate cancer—many men with high PSA levels don’t.  about a quarter of men who turn out to have prostate cancer have a low PSA level, less than 4 nanograms per milliliter.  about 25 percent of men with a PSA between 4 and 10 turn out to have cancer. 

Regular Member

Date Joined Nov 2005
Total Posts : 154
   Posted 6/12/2007 8:34 PM (GMT -6)   
Hi Bluebird,

Excellent post! Thank you so much for the info.

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