Under the latest grading system, biopsies
are not given a third number. The first number is the most prevalent pattern, but the second number is the highest grade pattern after the first number.So, for example, a tumor in a biopsy core that is 96% pattern 3, 3% pattern 4, and 1% pattern 5, is given as GS 3+5. Ideally, the pathologist should also give the percent pattern 4 or 5.
Surgery pathology is different. The higher grade pattern must be above 5% of the whole tumor to be given as the second number; if less than 5%, it is given as a tertiary grade. So, for example, a whole tumor that is 50% pattern 3, 40% pattern 4, and 10% pattern 5 is given as GS 3+5. But if it were 50% pattern 3, 46% pattern 4, and 4% pattern 5, it is given as GS 3+4 with a tertiary 5
Allen - not an MD
•PSA=7.3, prostate volume=55cc, 8/17 cores G6 5-35% involvement
•SBRT 9 yr onc. results
•SBRT 7 yr QOL results
•treated 10/2010 at age 57 at UCLA,PSA now: 0.1,no lasting urinary, rectal or sexual SEsmy PC blog