Pathology research - this is amazing

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New Member

Date Joined Aug 2007
Total Posts : 9
   Posted 8/10/2007 12:25 AM (GMT -6)   
I spoke to a research pathologist, and he did a DNA analysis of 7 positive cores in a prostate, and found all 7 had a different DNA. That means that in this case we're fight 7 different cancers, not just one. Boy does that throw a monkey wrench into the treatment (Provenge won't work, for example). These cancers could be anything form non-invading, to very aggressive. That could explain why some people don't do well with treatment, and others do extremely well.

Tony Crispino
Veteran Member

Date Joined Dec 2006
Total Posts : 8128
   Posted 8/10/2007 4:01 AM (GMT -6)   
Great post.
And most don't realize that there are several reasons why for PCa.
All can affect the reason that the cells broke apart from the standard DNA.  I spoke to my oncologist on this and he told me that when cells mutate there can be several reasons including the DNA make up.  It goes with the fact that everyone has cancer cells but the immune system kills 99.999% of the mutations.  When they grow out of control and form a tumor that is when you finally have what is called cancer.  There are many contributers including those listed above.  I asked if the DNA make up effects the treatment.  He said not usually.  But he did say that sometimes the DNA mutation makes cells more resilient to different treatments.  On the opposite end sometimes agressive cells are easily coaxed into remission as their dna has made them less tolarable to treatments such as HT.

Oy, this is quite confusing enough.


Post Edited (TC-LasVegas) : 8/10/2007 9:50:32 AM (GMT-6)

Regular Member

Date Joined Nov 2005
Total Posts : 154
   Posted 8/10/2007 8:40 AM (GMT -6)   
Wow, that is amazing. Thanks for sharing.

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