hormone treatments

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mgl
Regular Member


Date Joined Feb 2007
Total Posts : 122
   Posted 8/14/2007 4:36 PM (GMT -7)   
Just how are HT administered orally, injections?? and what are the cons of HT
50 years old
gleason 3+4=7 psa5.8 clinical stageT2a
Da vinci surgery April10 2007 Mayo clinic Rochester, Mn.
extraprostatic extension Gleason -same
pelvic lymph nodes -negative
Catheter out April 19


Gordy
Veteran Member


Date Joined Jun 2005
Total Posts : 528
   Posted 8/14/2007 4:47 PM (GMT -7)   
You've been "here" since February and are 4 months post surgery and you still haven't read enough online or the old fashioned way (books) to know the answers to your questions? Are you aware you could lose your life to this thing?

-Gordy

myman
Veteran Member


Date Joined Feb 2007
Total Posts : 1219
   Posted 8/14/2007 6:15 PM (GMT -7)   
mgl - Lupron which my husband is on, is given to him every 3 months by injection in the stomach. He has these side effects:
hot flashes, joint pain, muscle weakness, difficulty sleeping but is able to deal with them. He works out to counteract the muscle weakness & joint pain, takes Lunesta at times to sleep and turns the ac down. Sometimes moody, but hey...why not?

gordy - glad to see you back.

Susan

Gordy
Veteran Member


Date Joined Jun 2005
Total Posts : 528
   Posted 8/14/2007 6:21 PM (GMT -7)   
Thanks Susan.

Haven't been away except for the week before last which I spent in Houston at M.D. Anderson Hospital finding out just how bad my metasteses really are. Starting to get my affairs in order. Prolly the reason why I have no patience for guys who haven't a clue.

-Gordy

IdahoSurvivor
Veteran Member


Date Joined Aug 2007
Total Posts : 1015
   Posted 8/14/2007 8:14 PM (GMT -7)   
Many of you may have seen the following article at the Prostate Cancer Research Institute website. I found it interesting.

It is titled "Beating Prostate Cancer with Hormonal Therapy"
http://prostate-cancer.org/education/andeprv/Myers_HormonalTherapyDiet.html

Hope this helps!

Idaho
Age: 54
PSA: 4.3
Biopsy: T1c, 3+3=6, 2 pos. samples in one node, <5% volume
Da Vinci 31 Jul 2007: saved nerve bundle on side of non-cancerous node
Final pathology: Confined to prostate, T2a, 3+3=6, <1% volume
Working to get back into good shape
Waiting to take that first post-op PSA


Cedar Chopper
Regular Member


Date Joined Mar 2007
Total Posts : 432
   Posted 8/15/2007 3:37 AM (GMT -7)   
MGL,

Hopefully Tony will give you a short summary of some of his research, experiences, and very thoughtful decision-tree work on HT treatments.  (Look for his Journey under TC-Las Vegas.)

At my pre-surgery 2nd opinion consultations at M.D. Anderson, Dr. Maten indicated that he recommends considering the HT approach first for most capsular penetration.

I'm sure the decisions are more complex and individualized than this generalized comment.

While I don't look to be a candidate for HT Therapy (See updated signature below!), I really do appreciate the question and Susan's information.

Sincerely,

CCedar
ICTHUS!
2 Years of PSA between 4 and 5.5  + Biopsy 23DEC06 
Only 5 percent cancer in one of 8 samples.  +  Gleeson 3+3=6
Radical Prostatectomy 16FEB07 at age 54.
1+" tumor - touching inside edge of gland.  + Confined:)
Pad Free @ 14 weeks.  Six Month PSA <.003  :)
At 6 months, ED treated with Pump Exercises & 50mg Viagra Daily
Texas Hill Country FRESH Produce Department Manager
Have you had your 5 colors today?


aus
Regular Member


Date Joined Sep 2006
Total Posts : 211
   Posted 8/15/2007 5:31 AM (GMT -7)   

I would also recommend reading Dr Myers publication " Beating Prostate Cancer: Hormonal Therapy & Diet"

As previously mentioned here, the potential side effects of HT can be reduced with lifestyle changes: I know two men currently on HT and they are both doing  well, with few side issues. One is 60 years old and the other is 89.


Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8122
   Posted 8/15/2007 10:21 AM (GMT -7)   
Hi mgl,
There is usually two things you have happen with HT. First, I was given a prescribed drug, Casodex. It was in 50mg doses. The reason it was prescribed first was to prevent HT flare up. In most cases when the first time you take an HT shot PSA will rise before it falls. The flare period is about a week or so. Casodex is an oral chemotherapy drug that blocks fast growing cells from absorbing testosterone and can also be used to minimize flare up.

Second you get an injection under the skin of Lupron, Zoladex, or Eligard. My shot of Lupron was in my rear. I don't know the qualitative differences from the Zoladex or Eligard and my oncologist just told me to pick my own treatment. He stated that they are all LHRH blockers and have the same side effects. I told him then to pick it and it was Lupron.

There are a couple ways of administering HT. For a two-three year period, or what is called intermittent hormone therapy. As long as your PSA is <0.1 before and during HT then the oncologist may suggest removing the HT in 8 months or so. If there is no rise in PSA then HT is not re-administered until there is a PSA rise and a doubling rate is determined. This intermittent approach has two effects. First, it increases the likelyhood that the cancer won't become refractory soon. This is important because hormone refractory disease is potentially and likely terminal. Not always, but it can and will be your biggest challenge in this fight. The second benefit of intermittent HT is that the side effects of HT are heavily reduced.

In either treatment option, Casodex will be taken daily for the duration of the HT and in some cases, beyond HT treatment. When I was prescribed HT, my doctor also prescribed Fosamax to slow the onset of osteoperosis. In addition, he suggested I take the over the counter supplement Viactive. This increases my calcium and Vitamin D. This is also to offset the osteoperosis.

The biggest side effects of HT are the onset of osteoperosis and loss of muscle mass, and depression. Both the physical side effects are usually irreversable. The depression can be treated and usually goes away when halting HT. HT is by far the biggest provider of side effects. Providing it is something that the oncologist has to weigh against quality of life before administering it.
aus, recommendation of the Myers book is I believe required reading for HT recipients.

Tony

myman
Veteran Member


Date Joined Feb 2007
Total Posts : 1219
   Posted 8/15/2007 11:41 AM (GMT -7)   
MGL - Don's docs said because of his Stage IV he will be on the Lupron indefinately.

Gordy - come on back on here, please. We need you.

Susan

mgl
Regular Member


Date Joined Feb 2007
Total Posts : 122
   Posted 8/15/2007 2:08 PM (GMT -7)   
Thanks to all of you for the info, alot to process
50 years old
gleason 3+4=7 psa5.8 clinical stageT2a
Da vinci surgery April10 2007 Mayo clinic Rochester, Mn.
extraprostatic extension Gleason -same
pelvic lymph nodes -negative
Catheter out April 19

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