With a very BIG heart...I don't know that this is a marker or not but I am able to find some stuff on the web about
it as it pertains to PCa. Below is one example. There is an indication that it can be irrelebant...
The following study was from reuters...
Chromogranin A Level May Help Predict Prostate Cancer Prognosis
NEW YORK Feb 26, 2002 (Reuters Health) - In men with prostate cancer, elevated chromogranin A levels are associated with high grade disease, according to a report published in the February issue of The Journal of Urology. When combined with PSA measurements, these levels could be helpful in predicting prognosis after endocrine therapy.
Dr. Shinzou Isshiki and colleagues, from Chiba University in Japan, assessed the predictive value of serum chromogranin A levels in 108 prostate cancer patients and in 66 men with benign prostatic hyperplasia. After chromogranin A determination, the cancer patients received endocrine therapy.
The average chromogranin A concentration in both groups of men was similar, the authors note. Among men with cancer, however, those with poorly-differentiated disease had significantly higher levels (45.3 ng/mL) than those with well-differentiated disease (72.5 ng/mL, p = 0.044).
In patients with stage D disease, survival was significantly lower in patients with chromogranin A levels above the median level of 49.7 ng/mL than in those with lower levels. However, when PSA levels exceeded 172.1 ng/mL, the chromogranin A level had no bearing on prognosis.
The current findings indicate that "cases of prostate cancer associated with low serum PSA and high serum chromogranin A...may show resistance to endocrine therapy and a poor prognosis," the author state.
Age 45 (44 when Dx)
Pre-op PSA was 19.8
Surgery on Feb 16, 2007
Post-Op Pathology was poor: Gleason 4+3=7, 4 positive margins, Stage pT3b (Stage III)
HT began in May, '07 with Lupron and Casodex 50mg
IMRT radiation for 38 Treatments ending August 3, '07
My PSA did drop out after surgery to undetectable. It has not returned and I will continue HT until January '08.
My Life is supported very well by family and friends like you all.