What is a Nadir PSA?

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mariateresa
Regular Member


Date Joined Jun 2007
Total Posts : 95
   Posted 9/8/2007 3:34 PM (GMT -7)   
Hi!

I was reading some of the post-op instructions and it states that Rod will have to get a Nadir PSA. What is a Nadir PSA? Is it different than a regular PSA test?

Maria Teresa
Husband Age 55 Maria Teresa age 44

Total PSA 8 on 05/21/07

DRE: prostate bumpy

Biopsy on 07/16/07: 5 out of 8 cores positive, Gleason Score 8 (3+4+5)**

CT of the abd/pelvis; Bone Scan; Xrays done on 08/13/07: Normal

Robotic Surgery Scheduled for September 11, 2007


**"Report to the Nation on Prostate Cancer" published by the Prostate Cancer Foundation, page 11: "In some cases, the pathologist might identify a third pattern, which is less common but that has a higher grade than either of the first two patterns that comprised the Gleason score. The presence of this third pattern might indicate that the tumor is more aggressive than the Gleason score would otherwise imply. For example, if a Gleason 4+3 tumor also has some grade 5 cells, the cancer would be considered as being of higher grade disease overall."


Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8122
   Posted 9/8/2007 3:58 PM (GMT -7)   
Hi Maria Teresa,
This link might get you there.

http://www.boodrow.com/cancer/psanadir.htm

Tony
Age 45 (44 when Dx)
Pre-op PSA was 19.8
Surgery on Feb 16, 2007
Post-Op Pathology was poor: Gleason 4+3=7, 4 positive margins, Stage pT3b (Stage III)
HT began in May, '07 with Lupron and Casodex 50mg
IMRT radiation for 38 Treatments ending August 3, '07
 
My PSA did drop out after surgery to undetectable.  It has not returned and I will continue HT until January '08.
 
My Life is supported very well by family and friends like you all.
 
STAY POSITIVE!


Gordy
Veteran Member


Date Joined Jun 2005
Total Posts : 528
   Posted 9/9/2007 11:32 AM (GMT -7)   
Hey Tony & Maria Teresa-

Don't take everything that Dr. (PhD) Lewis says in that article as gospel - there are some errors. But, you're right - for a general discussion of what nadir means, it's OK.

-Les
1/2005 Dx PSA 26.5 Gleason 7 (4+3) @Age 61
1/2005 Start Casodex and Zoladex
PSA drops to <0.01 AND REMAINS THERE TO THIS DAY
7/2005-8/2005 5 w1/eeks of IGRT and then HDR brachy
1/2007 Rad Oncologist orders CT scan of pelvis
because of complaints of pain in both thighs
MRI confirms pain not caused by cancer BUT
1/2007 CT scan of pelvis picks up a nodule at bottom of left lung
5/2007 CT scan of lungs shows 1/2007 nodule has grown and
there are numerous nodules on both lungs.
6/2007 Thoracic surgeon removes wedge of left lung for biopsy
6/2007 Path report says 95% chance of metastatic PCa, but she's
never seen cells like this before.
7/2007 2nd opinion at M.D. Anderson in Houston.
They confirm: mutated PCa, very rare, but seen there 2 or
3 times. Recommendation: have CT scans every 6 weeks
and watch for change. At that point start chemo and will
survive for 22 - 24 months thereafter.
PSA STILL UNDETECTABLE


mariateresa
Regular Member


Date Joined Jun 2007
Total Posts : 95
   Posted 9/9/2007 5:04 PM (GMT -7)   
Thank you so much Tony and Gordy!!!

Maria Teresa :)
Husband Age 55 Maria Teresa age 44

Total PSA 8 on 05/21/07

DRE: prostate bumpy

Biopsy on 07/16/07: 5 out of 8 cores positive, Gleason Score 8 (3+4+5)**

CT of the abd/pelvis; Bone Scan; Xrays done on 08/13/07: Normal

Robotic Surgery Scheduled for September 11, 2007


**"Report to the Nation on Prostate Cancer" published by the Prostate Cancer Foundation, page 11: "In some cases, the pathologist might identify a third pattern, which is less common but that has a higher grade than either of the first two patterns that comprised the Gleason score. The presence of this third pattern might indicate that the tumor is more aggressive than the Gleason score would otherwise imply. For example, if a Gleason 4+3 tumor also has some grade 5 cells, the cancer would be considered as being of higher grade disease overall."

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