Need some info from the group

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War-eagle
Regular Member


Date Joined Sep 2007
Total Posts : 219
   Posted 10/11/2007 4:05 PM (GMT -7)   
I just got my results back from my monthly Zometa infusion and blood work. My PSA had a sight rise to 5.4. We had a testosterone level run for the first time. It was 28. I take that to mean 28ng/ml.
I have read that while being on HT and Casodex that it should be <20ng/ml. Any ideas? Is this a little high? Ongologist's nurse expressed no concerns, but I just wanted some feedback from by board of advisers.
Waiting for your input.
 
War Eagle, Ya'll.
Walt
Age: 54
PSA 43 7/2005
Biopsy 12/14 Gleason 7 & 9
Divinci 9/2005 - spread to bladder
HT - 10/2005 (Eligard every 6 months)
RT - 10/2005 (38 treatments)
PSA 0.12 to 1.9 2/2007
Bone Scan and CT 4/2007
Casodex 4/2007
Spread to Spine (L4 & T5), rib, and pelvis
Zometa infusions 4/2007
PSA 4.8 8/2007
PSA 4.9 9/2007
PSA 5.4 10/07
 
"I will persist without exception - I will find a way where there is no way"


Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8122
   Posted 10/11/2007 4:38 PM (GMT -7)   
Walt,
I have read where hormone refractory prostate cancer (HRPC) patients where incorrectly declared with HRPC because the androgen deprevation was not acheiving it's goal of lowering the testosterone and/or dihydrotestosterone levels to efficient levels preventing the cell mestasis. At least in the Myers book he references examples of patients who came to him that were HRPC but he was able to re-invoke remission. While there are several different ways to do it, he focussed on the Lupron/Eligard/Zoladex variations for the LHRH end of it. He said one might work better than the other depending on the patient. In addition he varied the levels of Casodex and combined either Avodart or Proscar, for a triple androgen blockade. Along with some other agents he was able to get the testosterone levels lower and the PSA's dropped. I ran this by my guy and he agreed that the levels need to be monitored if there was rising PSA to determine if another combination might have a stronger effect. That stated the levels that Myers would like to achieve is 10-30ng/dL for testosterone and dihydrotestosterone should be <5ng/dL. Lupron/Eligard/Zoladex do not always lower the DHT and that Proscar was his drug of choice to knock it down.

Tony


Age 45 (44 when Dx)
Pre-op PSA was 19.8
Surgery on Feb 16, 2007
Post-Op Pathology was poor: Gleason 4+3=7, 4 positive margins, Stage pT3b (Stage III)
HT began in May, '07 with Lupron and Casodex 50mg
IMRT radiation for 38 Treatments ending August 3, '07
 
My PSA did drop out after surgery to undetectable.  It has not returned and I will continue HT until January '08.
 
My Life is supported very well by family and friends like you all.
 
STAY POSITIVE!

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