I am a 55 year old and have just started hormone injections (Zoladex) to control my prostrate cancer. I have been offered the opportunity to join a clinical trail which is looking at new drugs that have shown to be active against prostrate cancer in later stages after hormone treatment stops working.
The new treaments are Zoledronic acid to help bones resistant to cancer cells, Docetaxel a chemotherapy drug to stop cells dividing and multiplying and Celecoxib a arthritis drug that slows the groth of cancer cells in laboratiy tests.
The aim of the trail is to investigate whether combining these drugs with hormone treatment can lengthen the time before the cancer starts to grow again. The treament I will recieve is random and could be hormone plus one or two of the new treatments. A higher proportion of men in the trial will though only recieve hormone treatment only.
However, if I agree to be involved in the trial I will not be able to have intermittent hormone treatment (stopping hormone treatment after 6/7 months and starting again after the cancer starts growing again). I have not been able to find any evidence that intermittent is anymore effective than continual hormone treatment (you do though get a break from the side affects).
Does anyone have any knowledge or experience of intermittent against continual hormone treatment?
I have to make the judgement to join the trial and hope I get one or two of the new treatments but accept I might only get hormone treatment. If I only get hormone treament I will have the advantage of being monitored closely.
However the issue of intermittent/continual hormone treatment outside of the trial is making my decision harder, albeit that this is dependent on my PSA level coming down to a satifactory level after 3 months of hormone treatment.