Experiences of using intermittent hormone treatment

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Colj_uk
New Member


Date Joined Nov 2007
Total Posts : 9
   Posted 11/4/2007 5:38 AM (GMT -7)   
I am a 55 year old and have just started hormone injections (Zoladex) to control my prostrate cancer. I have been offered the opportunity to join a clinical trail which is looking at new drugs that have shown to be active against prostrate cancer in later stages after hormone treatment stops working.
 
The new treaments are Zoledronic acid to help bones resistant to cancer cells, Docetaxel a chemotherapy drug to stop cells dividing and multiplying and Celecoxib a arthritis drug that slows the groth of cancer cells in laboratiy tests.
 
The aim of the trail is to investigate whether combining these drugs with hormone treatment can lengthen the time before the cancer starts to grow again. The treament I will recieve is random and could be hormone plus one or two of the new treatments. A higher proportion of men in the trial will though only recieve hormone treatment only.
 
However, if I agree to be involved in the trial I will not be able to have intermittent hormone treatment (stopping hormone treatment after 6/7 months and starting again after the cancer starts growing again). I have not been able to find any evidence that intermittent is anymore effective than continual hormone treatment (you do though get a break from the side affects).
 
Does anyone have any knowledge or experience of intermittent against continual hormone treatment?
 
I have to make the judgement to join the trial and hope I get one or two of the new treatments but accept I might only get hormone treatment. If I only get hormone treament I will have the advantage of being monitored closely.
 
However the issue of intermittent/continual hormone treatment outside of the trial is making my decision harder, albeit that this is dependent on my PSA level coming down to a satifactory level after 3 months of hormone treatment.
 
 
Thanks Col

Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8122
   Posted 11/4/2007 7:14 AM (GMT -7)   
Hi Col,
Sorry to welcome you to he site, but you are most welcome to post as you wish. I have studied extensively about intermittent ht and know why you are not able to find much about it. It has only been around as a practice most recently in last ten years and there are very little studies that can tell us if it is actually effective. Most studies for prostate cancer are ten year studies. Because of that the treatments in those studies are ten years older than todays treatments and their effectiveness is very subjective. Sterd82 is in the midst of treatment with the logic of using intermittent treatment and it is still my choice to stop HT in January if my oncologist agrees. Dr. Snuffy Myers has written a book entitled "Beating Prostate Cancer: Hormonal Therapy & Diet" and in it he speaks extensively about intermittent HT. You are supposed to get a break from side effects but I don't think that has been Sterd's experience as yet. Still I remain optimistic that it is the right approach for me. I am just 45 and don't like the prospect of extended use of HT. But I have fared well with the treatements thus far and to this point have not had a PSA rise. If you can, create a signature in the control panel and if you don't mind share with us your clinical information: PSA, Gleason, stage, etc. There are others here who may be able to lend you more information if they can see your picture more clearly. If you can also reveal the name of that study.

Tony
Age 45 (44 when Dx)
Pre-op PSA was 19.8
Surgery on Feb 16, 2007
Post-Op Pathology was poor: Gleason 4+3=7, 4 positive margins, Stage pT3b (Stage III)
HT began in May, '07 with Lupron and Casodex 50mg
IMRT radiation for 38 Treatments ending August 3, '07
 
My PSA did drop out after surgery to undetectable.  It has not returned and I will continue HT until January '08.
 
My Life is supported very well by family and friends like you all.
 
STAY POSITIVE!


Colj_uk
New Member


Date Joined Nov 2007
Total Posts : 9
   Posted 11/4/2007 7:49 AM (GMT -7)   

Hi Tony,

Good to hear from you.

My PSA level was 131 and Gleason rating of 10, hence the importance of keeping it at bay for as long as possible. I am considered stage 4 although scans have not shown it as spread but the PSA level indicated it has.

The clinical trail is called STAMPEDE.

 

Thanks Col

 

 

 


Age 55
PSA prior to starting HT 131
HT (Zoladex) started 17th Sept 2007


Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8122
   Posted 11/4/2007 10:15 AM (GMT -7)   
That book I recommend has case studies with good success stories of PSA's over 1000. I do hope the best for you and that can acheive a long remission. Good luck in this endeover.

Tony
Age 45 (44 when Dx)
Pre-op PSA was 19.8
Surgery on Feb 16, 2007
Post-Op Pathology was poor: Gleason 4+3=7, 4 positive margins, Stage pT3b (Stage III)
HT began in May, '07 with Lupron and Casodex 50mg
IMRT radiation for 38 Treatments ending August 3, '07
 
My PSA did drop out after surgery to undetectable.  It has not returned and I will continue HT until January '08.
 
My Life is supported very well by family and friends like you all.
 
STAY POSITIVE!


lifeline
Regular Member


Date Joined Aug 2007
Total Posts : 67
   Posted 11/4/2007 2:12 PM (GMT -7)   
Hi Col: As TC said sorry you have to be here but welcome and this is a magnificent site. thank you so much for your info. my husband was diagnosed May 06 with stage 1v prostrate cancer which has metastised to his skeletal frame, hips, back, spine and shoulders. his is hormone resistant and he is now on his second drug to try and bring his psa back down. it is so encouraging to read what you posted. we are from northern ontario, canada and i'm the one doing the reading and research on this stuff. info like what you posted is helpful to me. now just trying to get our doctors to listen is another story. sometimes they will listen to info that you present and other times they don't. seems to depend on their mood. anyway, thanks and good luck with your fight. stay strong and fight hard. lifeline

Swimom
Veteran Member


Date Joined Apr 2006
Total Posts : 1732
   Posted 11/4/2007 2:16 PM (GMT -7)   
Just an FYI...

The very famous PCa specialist, Fred Lee, has been in intermittent HT for years. Google his name and read some interesting material on color doppler ultrasounds and cryo.

Swim
 


bluebird
Veteran Member


Date Joined May 2006
Total Posts : 2542
   Posted 11/15/2007 12:06 PM (GMT -7)   

  tongue   HiCol & Loved Ones…

 

Welcome   to…   ~ HealingWell ~

 

and

 

A   Special   Warm Welcome  to  You !

 

Knowledge gives us POWER….  POWER takes away the fear.

 

~     ~     ~     ~     ~     ~     ~     ~     ~     ~     ~     ~     ~

 

 Click  on  link  below for important information that will help you ~ help us!!

 

Welcome New Members ~ to HealingWell

 

 

The information (link) listed above is to help you get started on your journey. 

     It is a journey best traveled with friends. 

          Welcome ~ New Friend from all the members here... on HealingWell.com

 

v      IdahoSurvivor ~  Moderator for Prostate Cancer Forum

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v      bluebird ~  Moderator for Prostate Cancer Forum

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bluebird
Veteran Member


Date Joined May 2006
Total Posts : 2542
   Posted 11/15/2007 12:08 PM (GMT -7)   

  :-) Hey ~ Col,

Just a little note to say hi ~ and we hope to hear from you soon.  You've reached out so continue to do so!  This is the place to be!  Please ~ as time permits... touch base with all of us and let us know how you're doing.  Okay! In New Friendship ~ Lee & Buddy

 


mama bluebird - Lee & Buddy… from North Carolina

 

v          We invite you to visit our personal thread:  Click Here:  “Our Journey” ~ Sharing is Caring 

April 3, 2006  53 on surgery day

RRP / Radical Retropubic Prostatectomy

PSA 4.6   Gleason  3+3=6    T2a   Confined to Prostate

3rd PSA 08-07-2007 Less than 0.1 Non-Detectable :)


Colj_uk
New Member


Date Joined Nov 2007
Total Posts : 9
   Posted 12/7/2007 5:53 PM (GMT -7)   

Thanks for all the kind posts and thanks Tony for the recomendation of Dr Charles Myers 'Beating Prostate Cancer: Hormonal Therapy & Diet. I have managed to track down a copy which makes interesting reading although my Consultant Oncologist did not agree with his tripple hormone approach but it has given me hope that there is scope to try other strategies rather than move to Chemotherapy after Zoldex and Casodex stop working. She did agree with some of his additives with I will be taking.

Anyway after discussing the trial with my Consultant Urologist who stated that he certainly would not start me on intermittent HT I have decided to participate in the trial and have been randomised to have Celecoxib (asprin type drug used for treating arthritis which has proved promising in lab tests) in combination with HT for a double prong attack at slowing the cancer growth.

The fantastic news is that a little after 9 weeks of having Zolodex injections my PSA level (required as part of starting the trial) has fallen from 136 to 1.0.

Thanks again, Col


Age 55
PSA prior to starting HT 131
Gleason 10 (5+5)
HT (Zoladex) started 17th Sept 2007


biker90
Veteran Member


Date Joined Nov 2006
Total Posts : 1463
   Posted 12/7/2007 6:02 PM (GMT -7)   
Hey Col,

Great news on the PSA drop. Looks like you are responding well which is wonderful. Good luck and please stay with us...

Jim
Age 73. Diagnosed 11/03/06. PSA 7.05. Stage T2C Gleason 3+3.
RRP 12/7/06. Nerves and nodes okay.
Catheter out on 12/13/06.  Dry on 12/14/06.
Pathological stage: T2C. Gleason 3+4. Cancer confined to prostate.
PSAs from  1/3/07 - 10/17/07 0.00. 
Next PSA test on 1/15/08
 
"Patience is essential, attitude is everything."
 

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