First PSA result after 3 months on Zolodex

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Regular Member

Date Joined Sep 2007
Total Posts : 87
   Posted 11/8/2007 9:01 AM (GMT -6)   
Hello everyone
Just thought I would let you know, Rick's first PSA after 3 months on Zolodex has fallen to 2.3
We are really pleased with this as it's quite early days yet. I know it's not at the undetectable stage but feel it's a really dramatic drop
Can't keep the smile of my face :-)
Age - 59
Dianosed - July 07
Gleason 8 (4+4)
PSA - 17
Bone Scan - August 07 revealed mets to spine, neck, rib, shoulder and pelvis
MRI - August 07 revealed seminal vesicle involvement
Treatment - Zolodex started on August 10th

Tony Crispino
Veteran Member

Date Joined Dec 2006
Total Posts : 8128
   Posted 11/8/2007 1:11 PM (GMT -6)   
It IS a dramatic drop. And it will drop a bit more too. Here's our hope that it does, Julia. God bless you and keep it down.

Age 45 (44 when Dx)
Pre-op PSA was 19.8
Surgery on Feb 16, 2007
Post-Op Pathology was poor: Gleason 4+3=7, 4 positive margins, Stage pT3b (Stage III)
HT began in May, '07 with Lupron and Casodex 50mg
IMRT radiation for 38 Treatments ending August 3, '07
My PSA did drop out after surgery to undetectable.  It has not returned and I will continue HT until January '08.
My Life is supported very well by family and friends like you all.

Regular Member

Date Joined Sep 2007
Total Posts : 87
   Posted 11/10/2007 11:26 AM (GMT -6)   

Thanks for responding Tony

Are we being naive in being pleased that his PSA has gone down to this level?

We really dont know whether it should have gone lower than this - the nurse didn't really comment very much

I know a fair few people have looked at this thread but not commented. Is this because it's not such good news?

Sorry to sound paranoid but I would rather know than have false hope

Any comments  would be gratefully received


Age - 59
Dianosed - July 07
Gleason 8 (4+4)
PSA - 17
Bone Scan - August 07 revealed mets to spine, neck, rib, shoulder and pelvis
MRI - August 07 revealed seminal vesicle involvement
Treatment - Zolodex started on August 10th
First PSA test November 7th - 2.3

Veteran Member

Date Joined Oct 2006
Total Posts : 621
   Posted 11/10/2007 1:36 PM (GMT -6)   
Julia - any downward trend in PSA is a "good" thing. Don't ever hesitate to share with the group here. Often times we read a post but don't have anything specific to say, but everything we read helps and is important.

Congrats on the new lower reading . . . . . it'll only go down from here.

;o) Linda & Bob
Bob (61) - Laproscopic Prostate Removal Sept 27, 2006.
2 of 12 malignant biopsy samples - gleason 3 + 3 = 6.
Pathology - cancer completely contained, even a second more aggressive, previously undetected cancer)
PSA UNDETECTABLE Nov 2006, Feb, May, Oct2007.  ONE YEAR!!!! WHOOO HOOOO! 

Bob also has two secondary conditions -- Polycythemia (elevated red & white cells & platelets) and . . Myelofibrosis) -- If anyone has experience with or information on these, please email us.

Doting Daughter
Veteran Member

Date Joined Aug 2007
Total Posts : 1064
   Posted 11/10/2007 7:29 PM (GMT -6)   

Hi Julia! Congrats on the downward trend! Cheers to the good news and best wishes for a continued fall!  Hopefully 2008 will be full of 000000's for you guys! 

P.S. Don't worry about not getting a lot of posts.  Often times I am guilty of rejoicing in good news and not leaving comments.  Some people are more of silent supporters, but know that you have the love and support of MANY! 


Father's Information
DX July 15, 2007
Age 62 (now 63)
PSA 5.5
Original Gleason 3+4=7 
Post Surgery Gleason- 4+3=7
DaVinci Surgery Aug 31, 2007
Focally Positive Right Margin
One positive node
Bone Scan/CT Negative (Sept. 10, 2007)
T3a N1 M0
Oct. 17 PSA 0.07

Veteran Member

Date Joined May 2006
Total Posts : 2542
   Posted 11/10/2007 9:20 PM (GMT -6)   

Hi ~  MissyJ & Loved One,


The Power of Hope



KNOWLEDGE IS POWER... and POWER conquers fear



We've kept you close in thoughts and prayers as you’ve continued to move forward in your fight. 

“Your Journey” is a path filled with stepping-stones and each step is important…  so ~ keep moving forward… with “All of Us”…. walking *hand~in~hand and *heart~to~heart"* with you  ~   the road will be smoother.


Please ~ stay close with every step and you will feel “All of Our” strength surrounding you both.


This forum is a true blessing for all of us.  Taking the first step into reaching out is the greatest gift you just gave to you and yours.  Hold on tight as we traverse this path with you.  Good, Bad, and/or Scary…. We are here for you “both”…  Stay close ~ okay!


In Friendship ~ Lee & Buddy


“God Bless You” 

It's a little prayer  ~  "God Bless You" ...but it means so much each day,

It means may angels guard you and guide you on your way


*phrases borrowed from TimG*


Threads started by:  Missyj


11-08-07  First PSA result after 3 months on Zolodex

10-25-07  Some advice needed please

10-14-07  Zolodex = protruding stomach??

08-18-07  Why do doctors not offer radiotherapy?

09-16-07  Sunday morning blues

09-12-07  What is a 'normal' PSA reading?

09-09-07  Hello everyone - I'm new to the board

Veteran Member

Date Joined Feb 2007
Total Posts : 1219
   Posted 11/11/2007 11:23 PM (GMT -6)   

Missy & Rick,

Yes, the PSA drop is a good one!  We know the feeling of waiting for the 3 month test as many others do here.  I believe every drop is a good one...Don's took a while to drop to where it is and yes, we wanted results quicker!  That's human nature...and perfectly normal!

You guys are doing well - stay strong in this fight and we'll be here for each other!

All the best,


Husband Diagnosed 11/17/05 Age: 63 No Symptoms
PSA: 7.96, Positive DRE
Biopsy Right: 6 of 6 Cores Positive Biopsy Left: 1 of 6 Cores Positive
Gleason: 4+3 = 7 Stage: T2B N0 MX
3 mo. PSA Post LRP Surgery: 11.8, 12.9, 13.9 Bone scan, CT scan, Endorectal MRI, Chest XR - neg.
09/06/06: 6 mo. PSA: 18.8 Distant lymph node involvement Start HT Lupron 3 mo. shots
12/06/06: PSA 0.8
03/07/07: PSA 0.3
06/06/07: PSA 0.1
09/05/07: PSA 0.1

Veteran Member

Date Joined Nov 2006
Total Posts : 1464
   Posted 11/12/2007 12:02 AM (GMT -6)   
Hi Julia,

Its going DOWN. That's the good news, it has to go down to get to zero. Hopefully it will be there soon...

Age 73. Diagnosed 11/03/06. PSA 7.05. Stage T2C Gleason 3+3.
RRP 12/7/06. Nerves and nodes okay.
Pathological stage: T2C. Gleason 3+4. Cancer confined to prostate.
PSAs from  1/3/07 - 10/17/07 0.00. 
Started Tri-Mix on 8/7/07.  .05 ml and 50 mg Viagra.  It works!!!
Next PSA test on 1/15/08
"Patience is essential, attitude is everything."

Regular Member

Date Joined Sep 2007
Total Posts : 219
   Posted 11/12/2007 9:13 AM (GMT -6)   


My dear sweet friend. Any drop is great. Rejoice. Trends are everything. Rick's trend now is down. It will continue the slide to zero. Like my preacher always says, "you just gotta believe". The drop is major because of how far it dropped. 17 down to 2.3, that's huge. Keep the faith and keep pushing on. You are both in our prayers, as always.

With love and a great big War Eagle,


Age: 54
PSA 43 7/2005
Biopsy 12/14 Gleason 7 & 9
Divinci 9/2005 - spread to bladder
HT - 10/2005 (Eligard every 6 months)
RT - 10/2005 (38 treatments)
PSA 0.12 to 1.9 2/2007
Bone Scan and CT 4/2007
Casodex 4/2007
Spread to Spine (L4 & T5), rib, and pelvis
Zometa infusions 4/2007
PSA 4.8 8/2007
PSA 4.9 9/2007
PSA 5.4 10/07
PSA 6.4 11/07
"I will persist without exception - I will find a way where there is no way"

Regular Member

Date Joined Sep 2007
Total Posts : 87
   Posted 11/12/2007 2:27 PM (GMT -6)   

Yes it is good news, I'm sorry for getting paranoid it's just that when I checked out other people's signatures their PSA levels seemed to go down a lot quicker.

HIs actual figures were 17.7 down to 2.3 and given that the actual time from having the first hormone injection to the first blood test was only two and a half months I guess this is pretty good going

Good to hear from you Walt, think about you and yours often.

Thanks everybody for good wishes and not making me feel like a moaning whinge-bag :-)


Age - 59
Dianosed - July 07
Gleason 8 (4+4)
PSA - 17
Bone Scan - August 07 revealed mets to spine, neck, rib, shoulder and pelvis
MRI - August 07 revealed seminal vesicle involvement
Treatment - Zolodex started on August 10th
First PSA test November 7th - 2.3

New Member

Date Joined Nov 2010
Total Posts : 3
   Posted 11/12/2010 1:53 PM (GMT -6)   
Yippee for you two. Any drop is a good drop. Think of it as a percentage -- 17 to 2.3 represents more than an 80% drop.
I know it's tough to not only wait to get "The Number" every quarter [ask my very supportive wife she has to put up with me the day before labs] and it is human nature to wonder "was that enough of a decrease?" In my book any decrease is a good thing. It's taken me 15 months to get from 2640 to .0456 so as you can see from this post and the other kind posts every one reduces "The Number" at a different rate then others. Be happy!
Age: 51 when DX
DX: 8/4/10
Gleason: Rolled a pair of fours
PSA: 2640 [that is not a typo]
Bone Mets and two lymph nodes
Zolodex started 8/11/09

Veteran Member

Date Joined Apr 2008
Total Posts : 847
   Posted 11/12/2010 3:35 PM (GMT -6)   
Unfortunately this is an old thread. Rick had his first Zoladex shot and following blood test in 2007 -- three years ago. Since then his PSA continued to fall, but more recently has started rising rapidly.

More recent details:
Julia, I am sorry to hear your news -- please do give us an update.

Ed C. (Old67)
Veteran Member

Date Joined Jan 2009
Total Posts : 2461
   Posted 11/12/2010 5:31 PM (GMT -6)   
Hi Julia,
That is dramatic drop in PSA. It shows that his PCa is responding well to the medication. Hopefully the trend will continue. Good luck moving forward.
Age: 67 at Dx on 12/30/08 PSA 3.8
2 cores out of 12 were positive Gleason (4+4)
Davinci surgery 2/9/09 Gleason 4+4 EPE,
Margins clear, nerve bundles removed
Prostate weighed 57 grams 10-20% involved
all PSA tests since (2, 5, 8, 11, 15, 18 months) undetectable
Latest PSA test (21 months) .005
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