Tofranil

Swimom

Veteran Member

Joined : Apr 2006

Posts : 1732

Posted 11/27/2007 6:21 PM (GMT -7)

Tofranil has a side effect of urinary retention....hope it helps :>)

Post edited: Subject showing No Subject....added Title

* bluebird ~ Moderator for Prostate Cancer Forum

Post Edited By Moderator (bluebird) : 11/28/2007 11:31:59 AM (GMT-7)

Veteran Member

Joined : Nov 2006

Posts : 883

Posted 11/27/2007 8:59 PM (GMT -7)

Swimmom, Do you know why or how it does it. Do you think it would be something I should ask my Dr about?

Willing to try anything at this point!

PSA 5.7 - Discovered during Annual Physical with Family Practice Dr.

Biopsy Sept. 27, 2006 - Diagnosis Sept. 29 - 3 of 12 positive (up to 75%) all on left side of prostate, Gleason 7

RRP on Oct. 17, - Nerves on right side saved.

All Lab's clear. No Cancer outside prostate

Cathiter in for 28 days due to complications in healing. Removed Nov. 9, 2006

First Post op PSA on Dec. 11, 2006 Undetectable 0.00

Office visit on Jan. 19th due to continued excessive urine leakage.

Feb.20th Cystoscope and 2nd Post Op PSA. Another 0.00.....:)

Dr. said everything looks fine. Continue to work Kegeal's. Leaking appears to have improved after Cystoscope?!?!?! Down to 3-4 pads per day!

March 1st Leaking has crept back up to 6 - 8 pads a day ???????

March 29th Collagen injection into sphincter / bladder neck area to control excessive leaking. Worked for a couple of days then back to leaking.

April 17th (Six Months Post Op) 2nd Collagen Injection to control excessive leaking. Leaking started back next day at work!

May 14th Second Opinion about my leaking and Options at OU Medical Center. After reviewing my records the Dr. feels I will probably need some surgical intervention to stop my leaking. But did agree to try Bio-Feedback and work hard on the Kegeal's first!

May 30th Follow up with my Dr. and 3rd Post Op PSA 0.00 agian!!!

June 1st Start Bio-Feedback to try to control my leaking.

Oct 17, 2007 1 year Post Op - Still fighting moderate / Severe incontenance. Using 4-6 pads a day. Erections usable....sometimes!...Better with 100mg Viagra

Swimom

Veteran Member

Joined : Apr 2006

Posts : 1732

Posted 11/27/2007 9:44 PM (GMT -7)

KW,

I'd have to look in the PDF to remember but I know its been used in the past for treating bed wetting in children.
A history of difficulty urinating is one of its contraindications. I'll try to look it up to refresh my memory.

Swim

mochapj

Regular Member

Joined : Jun 2007

Posts : 22

Posted 11/28/2007 5:57 AM (GMT -7)

According to what I read: "Mayo Clinic" Tofranil causes the bladder muscle to relax while causing the smooth muscles at the bladder neck to contract.

Another site reported that it causes increased muscle tone in the bladder neck. It is an antidepressant which has also been used to help with bed wetting in children.

Julie

Swimom

Veteran Member

Joined : Apr 2006

Posts : 1732

Posted 11/28/2007 10:25 AM (GMT -7)

Not sure how this ended up a seperate post from my reply but BLUE-----BIRD...can you fix it? :>)

mochapj

Regular Member

Joined : Jun 2007

Posts : 22

Posted 5/19/2008 5:12 AM (GMT -7)

Just thought I would update everyone on the Tofranil medication that my dad started. It's been about 5 months that he's been on it and his incontinence is still about zero.

I just talked to him a little bit ago and he was going to start weaning himself off of it and see if there was any difference. He had surgery last August and started Tofranil in Dec or Jan...I really can't recall. He had pretty significant incontinence up until that point, and the week he started the drug there was an amazing difference. So was it due to natural recovery or medication, we really won't know. But whatever it was it worked.

Julie

DanmanBob

Regular Member

Joined : Feb 2008

Posts : 467

Posted 5/19/2008 9:21 AM (GMT -7)

Any big side effects?

I have kidney disease, so wondering if I would be a candidate?

Danman Bob, Born 1951

Nerve-sparing, open prostate surgery November 13, 2007

Gleason score 9, PSA 14; Biopsy result - 9 of 12 sticks showed cancer

Post-op pathology stated that cancer was confined to the prostate

Unrelated surgery January 2008 delayed incontinence recovery, which is now showing good signs of improvement (fraction of a pad a day as of late April 2008)

100 MG Viagra 3 times a week beginning December 2007

Osbon Erec-Aid Esteem manual pump for therapy beginning mid-February 2008

30 MG papaverine/1 MG phentolamine bimix injections beginning late April 2008

Five week post-op PSA 0.2, five month post-op PSA 0.1, next test August 2008

mochapj

Regular Member

Joined : Jun 2007

Posts : 22

Posted 5/19/2008 9:29 AM (GMT -7)

He hasn't noticed any side effects....I think it says the usual...dry mouth etc..and I don't really know about contraindications??

He was just happy that "something" helped the incontinence. He had an appointment scheduled at an incontinence clinic and really felt like he didn't need to go by the
time the appointment came around. He did keep the appointment though.

Julie

Gordy

Veteran Member

Joined : Jun 2005

Posts : 528

Posted 5/19/2008 4:00 PM (GMT -7)

Swim-

You've been on the 'puter too much. PDR, not PDF.

-Les

1/2005 Dx PSA 26.5 Gleason 7 (4+3) @Age 61
1/2005 Start Casodex and Zoladex
PSA drops to <0.01
7/2005-8/2005 5 weeks of IMRT and then HDR brachy
1/2007 Rad Oncologist orders CT scan of pelvis
because of complaints of pain in both thighs
MRI confirms pain not caused by cancer BUT
1/2007 CT scan of pelvis picks up a nodule at bottom of left lung
5/2007 CT scan of lungs shows 1/2007 nodule has grown and
there are numerous nodules on both lungs.
6/2007 Thoracic surgeon removes wedge of left lung for biopsy
6/2007 Path report says 95% chance of metastatic PCa, but she's
never seen cells like this before.
8/2007 2nd opinion at M.D. Anderson in Houston.
They confirm: mutated PCa, very rare, but seen there 2 or
3 times. Recommendation: have CT scans every 6 weeks
and watch for change. At that point start chemo and will
survive for 22 - 24 months thereafter.
PSA still undetectable, but get Lupron shot to bring T down from 27
2/2008 Trip to Houston – PSA now 0.5 and nodules larger. Lupron shot.

Swimom

Veteran Member

Joined : Apr 2006

Posts : 1732

Posted 5/19/2008 7:30 PM (GMT -7)

LOL...funny, I never noticed the typo...Physician's Desk Ref...thanks for the edit :>)

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