I have been on Casodex for about 6 years. I was originally on 150mg, now on 100 mg/day.
Side effects are minimal. My PSA was very low, but rising. While on Casodex my PSA has held.
Dr Myer's book "Beating Prostate Cancer: Hormonal Therapy & Diet" is worth reading.
He gives several case studies, including two patients who had PSA readings of 3488 and 3656 and subsequently responded well to treatment.