Thanks Veteran for your comments.
There are many misunderstandings about the usefulness of both psa and testing with psa. For the most authoritive explanation of these misunderstandings, I recommend a booklet called HORMONE BALANCE FOR MEN, by John R Lee M.D. Dr. Lee does a remarkable job of clarifying what men need to know about prostate cancer and PSA, and he backs it up with ample references to scientific studies. In a nutshell, what Dr. Lee explains are the two biggest fallacies in mainstream medical thinking regarding prostate cancer, which are 1) that it is beneficial to lower the PSA count as an integral aspect of treatment,and 2) that blocking testosterone will inhibit the growth of prostate cancer. One of the most important concepts you will learn from Dr. Lee"s booklet, that even your doctor may not understand, is that when normal healthy cells of the prostate gland produce PSA it is simply in response to crowding ( or pressure). For instance, an infection on any type of inflamation in the prostate gland generally cause a rise in a man's PSA production because the swelling causes pressure or crowding of the normal cells. Even manually massaging the prostate gland will often cause a rise in PSA producton for the same reason. This PSA rise is the body's way to try to reduce this infection or inflamation, and indeed it has now been proven that the PSA itself is "ANTI-ANGIOGENIC" ,which is a process that inhibits the growth of new blood vessels to the tumor. So with this understanding,---it is clear that a man with prostate cancer would NOT WANT to artificially lower his PSA production through the use of hormone blocking drugs. Remember , if you have cancer anti-angiogenesis is always A GOOD THING.
Fallacy number two is that blocking testosterone will inhibit the growth of prostate cancer. In HORMONE BALANCE FOR MEN, Dr Lee goes into detail about how this medical fallacy got started, and also presents ample scientific evidence that proves this idea is indeed a fallacy. Common sense points out the fact that prostate cancer is almost non-existant in younger men,---AT A POINT WHERE THEIR TESTOSTERONE IS THE HIGHEST. You would think that if testosterone does indeed feed the prostate cancer, then we would have always seen the highest rates of this type of cancer in younger men.
As I said earlier, PSA has anti-angiogenic properties,so a man really doesn't want his PSA production reduced. Moreover, testosterone has the ability to oppose estrogen in the body. Men's bodies make estrogen too, though not as much as women's bodies. When a man's testosterone level is artificially reduced through the use of testosterone blocking drugs,---THAT ALLOWS A DANGEROUS SHIFT IN HORMONE BALANCE TO OCCUR,---a shift Dr Lee calls "estrogen dominance" Men can feel and see this shift take place when they take Lupron, Casodex, or other testosterone blockingdrugs,-as they experience enlarged or tender breasts and other syptoms of estrogen dominance. THIS IS A VERYDANGEROUS SHIFT TO ALLOW TO HAPPEN BECAUSE ESTROGEN DOMINANCE IS LIKELY TO PROMOTE THE GROWTH OF CANCER IN THE BODY.
In a nutshell, conventional doctors THINK they are reducig prostate cancer growth by blocking testosterone and artificially lowering PSA count. But what they are really doing by employing testosterone -blocking drugs is simply reducing the production of PSA in a cancer patient whose body is producing PSA as a defense agaist the cancer. This way of reducing the PSA has no correlation to a reduction in the man's cancer, and the resulting ESTROGEN DOMINANCE that occurs when testosterone is blocked COULD ACTUALLY PROMOTE THE GROWTH OF CANCER. Thus the use of testosterone blocking drug for prostate cancer is an extremely dangerous practice,---because it may PROMOTE the cancer growth in two ways, 1) BY REDUCING THE BODY'S ABILITY TO PRODUCE PSA THAT IS ANTI-ANGIOGENIC, and 2) BY PROMOTING ESTROGEN DOMINANCE.
iT MAY BE TIME FOR MEN WITH PROSTATE CANCER TO JUST SAY NO TO HORMONE-BLOCKING DRUGS, AND IT MAY ALSO BE TIME FOR A FAIR EVALUATION OF THE TRUE EFFECTIVENESS OF CONVENTIONAL PROSTATE TREATMENT VERSUS THE LATEST THE MORE PROGRESSIVE STUDIES .
age 68, T1c gleason 3+3=6, prostate 66cc, 3 positive out of 13
Scheduling surgery Feb 2008