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Regular Member

Date Joined Jun 2007
Total Posts : 29
   Posted 12/16/2007 6:22 PM (GMT -6)   
Does anyone have any experience with the MUSE approach to help with ED? I did a search on this forum but didnt find much. I'm 6 months after robotic operation and think I'm a little behind the curve in my ED recovery. Everything else is successful i.e., 6 month PSA still 0.01 and no leakage.

2 weeks ago I met with an associate urolgist in my surgeon's practice who specializes in ED issues. He suggested I try increasing the dose of the pills. I tried all 3 of, not at the same time ! :) Results of doubling the dose wasnt much better i.e., 200mg Viagra, or 40 Cialis or 40 Levitra. He had said at my first office consult with him that the next step was to try MUSE (for those of you unfamiliar, you insert a tiny pill into the penis and it works much the same as the injections) but without the "trauma" of having to stick yourself with a needle.

BTW, this doctor thinks no one treatment (pills, MUSE, injections, pump) is better than the other. I know I've read in this forum there are others who disagree, so I'm concluding that nobody really knows. He said all these ED treatments work on relaxing the muscles that allow blood flow to the penis and cause it to get hard. The goal is to prevent fibrosis, which I believe can occur when the muscle tissue gets too starved for blood and wont work like it should anymore. This all just gives the nerves time to heal to whatever state they will get to. According to a study he quoted, by taking even small daily doses of the pills, after 18 months, 70% of those men achieved erections good enough to have "normal" sex. Those in the control study who didnt take the pills only had a 40% success rate. And after 2 years, what you get is what you get. That's when things like penile implants get looked at.

I just thought I'd share what I've learned. Please dont anybody try messing with your Viagra, etc, doses without talking to your doctor.

So, anybody have any experience, good or bad with MUSE? Thanks.
Diagnosed Jan 07
PSA 5.79
Biopsy -12 samples, positive in 4, Gleason 3+3, T1c
Age 59
Surgery (robotic) June 1 2007
Final pathology - fully contained to prostate, <2% , Gleason 3+3
No leaking 2 months after surgery (Yahoo !)
3 month PSA <0.01 (Yahoo again !)

Regular Member

Date Joined Mar 2007
Total Posts : 114
   Posted 12/17/2007 1:54 PM (GMT -6)   
Tried the MUSE, ahted it, way too painful for anything resembling pleasurable intercourse

Diagnosed 1/26/07
Stage Tc1
Gleason 6
PSA 3.8
12 samples, positive in one 15%
Biopsy - 1% involvement, no bladder neck, Gleason 3+3, Tc1
Age 51
Surgery (robotic) May 4 2007 City of Hope
Final pathology - fully contained to prostate, TC1, Gleason 3+ 3
Fully continent one month
First Post op PSA - Undetectable
Second Post Op PSA (8/22/07)- Undetectable
ED- start injections 10/06/07
3rd Post op PSA 11/7 - Undetectable

Veteran Member

Date Joined Aug 2007
Total Posts : 1015
   Posted 12/17/2007 6:11 PM (GMT -6)   

Hi Grover,

I second Pete42's nomination against MUSE.  It is difficult to administer properly to be effective, it is unpleasant to administer at that, and it can cause a burning sensation in the urethra.  Can I say anything good about it?  No.  Sorry.

My vote would be to try something else.

All the best,


"Idaho" ~ Barry


Da Vinci Surgery July 31, 2007… 54 on surgery day
PSA 4.3  Gleason 3+3=6  T2a  Confined to Prostate

1st PSA 0.04 (undetectable) 9/11/2007

My web site:

Mike A
Regular Member

Date Joined Feb 2007
Total Posts : 213
   Posted 12/19/2007 8:14 AM (GMT -6)   
I haven't had any experience with MUSE, but my Doctor is recommending that as a next step for me too. I've been debating whether to try it or go straight on to the injections, but I'll wait and see what replies you get on this. Based on what I've read, so far I'm not too encouraged about MUSE. Thanks for starting this thread! Happy Holidays!
June 2005 - Age 53 PSA 4.8 at regular physical
October 2005 - After several rounds of anti-biotics, PSA 5.2 at Urlogist
November 2005 - Biopsy negative
July 2006 - PSA 5.9 at regular Physical
October 2006 - After several more rounds of anti-biotics PSA 8.1
November 2006 - Second biopsy - Positive
December 2006 - Gleason (3+4=7), Tumor T1c, CT Scan and Bone Scan Negative
January 2, 2007 Robotic Prostatectomy, University of Rochester Medical Center - Tumor confined but larger than thought, only one nerve able to be spared. Margins clear.
February 2007 - Three to four pads a day, no erection with viagara.
March 2007 - Down to two pads a day, had first intercourse with Erecaid pump and bands, otherwise still flat tire.
April 2007 - First Post-Surgical PSA 0.02 and a great relief! Down to one pad a day. Still unable to achive erection without pump.
May, 2007 - Still one pad a day, even try a smaller pad on occasion. Slight improvement on the ED.
July, 2007 - Six Month Post-op: PSA 0.04 still Non-Detectable. One small pad/day for a few drops only! No change in ED.
October, 2007 - Nine Month Post-op: PSA back down to 0.02 Non-Detectable...Yay! Almost totally dry! Only slight improvement in ED - Will try injections if not improved by next appointment.
"If patience is a virtue, I feel like the most virtuous guy on the planet!"

Regular Member

Date Joined Jun 2007
Total Posts : 29
   Posted 12/19/2007 12:50 PM (GMT -6)   
I met with the ED specialist yesterday. He said MUSE has been around before the Viagra drugs but was only effective in about 15% of the cases. When Viagra hit the market with 70-80% efficacy, MUSE lost popularity. The doc said if I decide to use it, to take it in conjunction with Viagra (or Cialis/Levitra), i.e., take a full dose of Viagra, wait 2 hours then use the MUSE. I havent decided whether to try it but will keep you guys posted if I do. Judging from the lack of response to my post, I dont see much interest in it here.

My main interest is to do everything I can now, and not hear 18 months from now that I should have tried something, and now it's too late. This doc thinks that just taking a small dose of the Viagra type drug every day will not only keep the muscle tissue from becoming fiberous, but also promotes healing of the nerves. I'm not sure about the nerve-healing claim. The truth is, he said, nobody knows for sure.
Diagnosed Jan 07
PSA 5.79
Biopsy -12 samples, positive in 4, Gleason 3+3, T1c
Age 59
Surgery (robotic) June 1 2007
Final pathology - fully contained to prostate, <2% , Gleason 3+3
No leaking 2 months after surgery (Yahoo !)
6 month PSA <0.01 (Yahoo again !)
ED a work in progress. Taking 50mg Viagra daily.

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