celiac disease or NON-CELIAC GLUTEN SENSITIVITY

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Ahmed-tl
New Member


Date Joined Sep 2015
Total Posts : 3
   Posted 9/6/2015 4:43 AM (GMT -7)   
Dears;
Thanks for give us the chance to ask our Question
we have just did the blood test from my kid 3 days ago
he is 4 years old ,
our doctor after checking the result Diagnosis as celiac disease and we told us that we should follow gluten -free diet
but after i read on the internet i found that
NON-CELIAC GLUTEN SENSITIVITY is different than celiac disease

and Diagnosis can be NON-CELIAC GLUTEN SENSITIVITY
these are the blood result

Anti-transglutaminase igA : <3.00U/ml
Anti-gliadine (igA) : 40.20 U/ml
Anti-gliadine (igG) : 5.8 U/ml


so can you help to Diagnosis if it is celiac disease or NON-CELIAC GLUTEN SENSITIVITY ? and is biopsy safe for his edge Thanks

cyclinglady
Regular Member


Date Joined Aug 2015
Total Posts : 151
   Posted 9/6/2015 10:58 PM (GMT -7)   
The next step after a positive celiac blood panel is an endoscopy taking at least six biopsy samples to confirm intestinal damage. The University of Chicago's celiac website is an excellent resource. Keep eating gluten until all testing is complete. Did your doctor refer your son to a Gastroentrologist?

Non-celiac Gluten Intolerance typically has negative results on the tests.

cyclinglady
Regular Member


Date Joined Aug 2015
Total Posts : 151
   Posted 9/6/2015 11:03 PM (GMT -7)   
Oh, no one wants to put a child through an endoscopy, but an official diagnosis is very helpful. You tend to get more medical, family and friend support. Please discuss this with your GI.

All first degree family members need to be tested as this is a genetic autoimmune disorder. Many celiacs can be symptom free.

Ahmed-tl
New Member


Date Joined Sep 2015
Total Posts : 3
   Posted 9/7/2015 12:46 AM (GMT -7)   
"Did your doctor refer your son to a Gastroentrologist?"
No she did not ,where she Babies doctor , & she asked me to follow gluten free diet
but i have just visit Gastroentrologist doctor by myself ,
he ask me to do the blood test again , tTG & Emma
where he said Elevation of Anti-gliadine (igA) only is not reference to diagnosis as CD
& yes ,he ask me to keep eaten gluten , until all tests finished
thank u cyclinglady i will keep u on update

cyclinglady
Regular Member


Date Joined Aug 2015
Total Posts : 151
   Posted 9/7/2015 7:07 AM (GMT -7)   
His statement is not true that she needs more positives on the other tests. He should check to see if he is (IGA) deficient. It is a control test. If yes, the (IGG) tests should be run. Kids and a few rare adults, like me, test with only a positive DGP IGA result and a negative TTG and EMA. My intestinal biopsies revealed a Marsh Stage IIIB which is moderate to severe intestinal damage.

These are all the tests for celiac disease:

-Tissue Transglutaminase (tTG) IgA and (tTG) IgG
-Deamidated Gliadin Peptide (DGP) IgA and (DGP) IgG
-EMA IgA
-total serum IgA and IgG (control test)
-AGA IGA and AGA IgG - older and less reliable tests largely replace by the DGP tests

-endoscopic biopsy - make sure at least 6 samples are taken

Please do a search regarding a positive DPG and negative TTG. Confirm if the older Anti-Gliadin tests were run and request the newer DGP tests.

Ahmed-tl
New Member


Date Joined Sep 2015
Total Posts : 3
   Posted 9/7/2015 9:26 AM (GMT -7)   
do i have to do it all , ?
because Unfortunately it seems that our analytical laboratories in our country has only
-Tissue Transglutaminase (tTG) IgA and (tTG) IgG
&
- AGA IGA and AGA IgG , even Ema do not have

today they take sample of my kid blood , & result need 5 days
i think , our Gastroenterologist doctor will depending on these results & his assessment to decide if he will do endoscopic biopsy or not
if he Suspect of CD he will do it

sorry because my medical terms is week , can you explain to me what do u mean by
"He should check to see if he is (IGA) deficient"
deficient mean helpless ,which in this case IGA can not be reliable ?
and we can know that from total serum IgA and IgG (control test)

cyclinglady
Regular Member


Date Joined Aug 2015
Total Posts : 151
   Posted 9/10/2015 8:46 AM (GMT -7)   
The AGA tests are older and were replaced by the DGP tests, but the AGA tests are still good! An IGA deficency test will help determine if the TTG and AGA IGA results are accurrate. It is a test control. Also, many celiacs are IGA deficient too. In your case, your child is NOT IGA deficient because she had that AGA IGA test was positive. Sorry, for not re-reading your first post.

Personally, I had only one positive on the DGP IGA and the rest of my celiac blood panel -- even the TTGs were negative, yet I had severe intestinal damage. Why? My doctors are puzzled because usually kids can be negative on the TTG tests and positive on the DGP or AGA tests. I am over 50! So, do not let the lack of a positive TTG Test throw you off to finding a correct diagnosis. Please search/Google "Negative TTG positve AGA celiac disease" and you will find many studies to support this.

I hope this helps!
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