Mesalamine enemas and diarrhea

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Mitzo
Veteran Member


Date Joined Dec 2007
Total Posts : 536
   Posted 12/23/2007 8:19 PM (GMT -7)   
Someone please tell me the salofalk enemas I have been on are causing be the stomach pain and drastic morning diarrhea I am having. Have had UC for 21 years and was OK until I had to take flagyl and humatin this past summer for amoebas. They gave me bigtime liquid diarrhea which was squelched by entocort, but bleeding and so on started so I am, after a colonoscopy, on salofalk enemas and off the entocort. It has been 4 weeks and the morning diarrhea and abdominal yuckiness is epic. Please tell me it is the enemas and not the stopping of the entocort.

jujub
Forum Moderator


Date Joined Mar 2003
Total Posts : 10405
   Posted 12/23/2007 8:49 PM (GMT -7)   
Mesalamine gives me ferocious D, whether I take it orally or rectally. But that's not the usual reaction, so it could really be either. You might try either stopping the mesalaming or going back on the entcort for a bit to see if it changes anything. The problem with changing two meds at once is that it's hard to differentiate which one caused any changes in your symptoms.
Judy
 
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Intolerant to Asacol and rectal mesalamine preparations.
On Prednisone then Entocort 2001-2006 with only short periods off. 
Current meds are Colazal, Azathioprine and Remicade.
In remission since April, 2006. Remicade has been my wonder drug.
 


Mitzo
Veteran Member


Date Joined Dec 2007
Total Posts : 536
   Posted 12/23/2007 8:55 PM (GMT -7)   
Thanks Judilyn, I am thinking it is the enemas since I also feel weirdly exhausted and wheezing/phlegmy too. One more day of enemas and I cut back to every two days. The last 4 months or so have been hell, and I have a new GP who is much less sympathetic than the other one, plus a gastro who seems addicted to colonoscopies.
21 years of UC which started after quitting smoking. In and out of flares which are usually triggered by antibiotics.


Mitzo
Veteran Member


Date Joined Dec 2007
Total Posts : 536
   Posted 12/23/2007 8:57 PM (GMT -7)   
BTW, what kind of med is remicade?
21 years of UC which started after quitting smoking. In and out of flares which are usually triggered by antibiotics.


gaff
Regular Member


Date Joined Jul 2006
Total Posts : 442
   Posted 12/24/2007 8:51 AM (GMT -7)   
Mesalamine enemas give me incredible diarrhea, make me tired, and make me feel like crap, but they do stop my bleeding. I was determined to take them because they stopped the bleeding that I had for 1 1/2 years.

I use 1/2 bottle every other day and have no side eefects from it. Try this regemin and see if it might help you.

Good Luck!
gaff
left-sided UC since 11/05
 Rowasa, Colazal, Calcium, Centrum
Natren Healthy Trinity Probiotics


jujub
Forum Moderator


Date Joined Mar 2003
Total Posts : 10405
   Posted 12/24/2007 10:38 AM (GMT -7)   
Mitzo, Remicade is an engineered drug originally developed to treat rheumatoid arthritis, now also used for a number of other auto-immune diseases including Crohn's and UC. Its generic name is inflixamib. It is an anti-tumor necrosing factor, a type of antibody. It's given every six or eight weeks through an IV infusion. Because it is very expensive, usually all of the more standard treatments (5-ASA's of different types and by different routes, steroids, immunosuppressants, etc.) are tried before it. For some of us it has been a godsend, for others it hasn't really helped. It put me into a remission when I couldn't get there with any combination of other drugs. I had gotten to the point of considering surgery after a four-year flare.
Judy
 
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Intolerant to Asacol and rectal mesalamine preparations.
On Prednisone then Entocort 2001-2006 with only short periods off. 
Current meds are Colazal, Azathioprine and Remicade.
In remission since April, 2006. Remicade has been my wonder drug.
 


Mitzo
Veteran Member


Date Joined Dec 2007
Total Posts : 536
   Posted 12/24/2007 2:40 PM (GMT -7)   
Thnks a lot to both of you and a Merry Christmas/Happy Holiday.
21 years of UC which started after quitting smoking. In and out of flares which are usually triggered by antibiotics.

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