My GI told me that sometimes people have better reactions to imuran when they have a bad to 6-mp and vice versa.
There are clinical trials.
Have you tried other types of 5ASAs besides Asacol?
Cyclosporine and Prograf are treatment options and very effective ones at that but they are not maintenance drugs.... you will probably need methotrexate or Imuran as a maintanence drug if 6-mp doesn't work for you.
I see that you are in Boston, Mass General is one of the best GI hospitals in the country.
I was in the hospital in October and I met with a surgeon who does 1-step Laprosocpic J-pouches.... you have to be off of Prednisone for a while first or you would need a 2-step surgery.
DX'd with Pan-Colitis June 2005
Current Status: Flaring since May
Current Meds: 50 mgs 6-mp, Colocort, Oral Cyclosporine (500 mgs)