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Regular Member

Date Joined Sep 2007
Total Posts : 221
   Posted 1/7/2008 12:57 PM (GMT -6)   
I was wondering how long Prednisone actually stays in your system.

I was on it for about 9-10 weeks. I tapered down and took my last dose about 3 weeks ago. Since then I've noticed that I've been crampy but I also have some body aches. I'm not sure what to think about this..........
Is it because my body is still adjusting without the Prednisone?
Is it because I might be fighting a cold or sickness or even the drastic weather changes?
Is it because my workouts have been to intense?

Aside from my body aches I seem to notice it more so in my ab & lower back area.

My bowl movements and everything else is perfect.

Any opinions on what you think might be going on would be appreciated.

started Prednisone & Asacol on Thursday 10-4-2007

currently OFF Prednisone

tabitha m
Regular Member

Date Joined May 2007
Total Posts : 139
   Posted 1/7/2008 1:05 PM (GMT -6)   
Sounds exactly like me when i came off it after 3 months. Quite achey, my knees really hurt and back , and still felt tired . All lasted about 6 weeks and then gradually started to really feel normal again ,
Hope this helps .
Diagnosed Proctitis 2003
leaped to Pancolitis May 2007
bye bye Pred (fingerscrossed )!
2000mg pentasa a day
omega 3
Allergic to Sulphalizine
In remission since june
Multivitamin and calcium supplement

Regular Member

Date Joined Sep 2007
Total Posts : 221
   Posted 1/7/2008 1:14 PM (GMT -6)   
that's what my plan is, is to give it more time.

As long as my bowl movements remain like they are, I'm not going to get to concerned.

Thanks for your input!
started Prednisone & Asacol on Thursday 10-4-2007

currently OFF Prednisone

Veteran Member

Date Joined Sep 2005
Total Posts : 698
   Posted 1/7/2008 1:15 PM (GMT -6)   
It took me a few months to start to feel "normal" (what is normal?) after being on the prednisone. i was lucky, in that i actually felt quite good on the pred, but im sure if i had been on longer term i would have had some more side effects.
35 year old Male, Husband, Father of the best three kids in the universe.
First Flare was February 2005. Diagnosed June 2005-left-sided Colitis, suspect it has since spread. Started 4000 mg Oral Salofalk June 2005-stopped January 2007. Remission until November 2006. Been in a flare to various degrees since November 2006 to February 2007. Currently in remission.
Presently on 0 mg Prednisone-down from 60 mg!
Weekly 4000 mg Salofalk enemas.
Daily 4000 mg Salofalk oral.
Started Omeprazole 20 mg February 2007.
Co-Moderator-UC Forum

Veteran Member

Date Joined Sep 2007
Total Posts : 955
   Posted 1/7/2008 9:21 PM (GMT -6)   
thanks for this post.. i was wondering the same thing... how long it takes for pred to get out of your system.
ive been off it for 2 weeks at least and still having effects..
like aches, weight gain, moon face, sweats, shakes... stuff like that.

glad to know it goes away!
i just want it to go away now!
steph - 31 - female - diagnosed UC in 2000
started as proctitis, went to pancolitis..then went back to left side only to splenic flexure.
last 3 weeks have been fabulous with no UC symptoms at all = remission (yey!) 
prednisone = finally finished!!!  woohoo!
1000mg mesalazine 2x day - 1/2 1/4 oxycodone every 6 12 18 hours (weaning)
calicim, inner health plus (probiotic), fentalyn patch for pain and to wean off oxycodone
VSL#3 didnt work - Aloe Elite didnt work - Budesonide didnt work
prednisone finally made me puff out on my last week of taking it ... bugger!

Regular Member

Date Joined Jan 2008
Total Posts : 90
   Posted 1/15/2008 5:26 AM (GMT -6)   
i have been off it 3 months i think, im still not what i was but i dont think i ever will be, i know my joint pain would be the arthritis that comes along with uc, ,my head hair is so so thin and now my leg hair is disaperaing this is a yukky disease

Veteran Member

Date Joined Aug 2007
Total Posts : 2204
   Posted 1/15/2008 10:06 AM (GMT -6)   

It's not a case of pred staying in your system. When you take prednisone, your adrenal glands stop making their own hormone.  After you stop taking it, your adrenal glands need time to resume their normal function.  The amount of time your adrenal glands need to fully recover depends on how long you took prednisone and the dosage.

Diagnosed with ulcerative colitis spring 1999
Therapeutic dose sulfasalazine.
Probiotics, l-glutamine and fish oil caps. George's aloe vera juice and Mucosaheal.

Regular Member

Date Joined Oct 2007
Total Posts : 320
   Posted 1/15/2008 6:56 PM (GMT -6)   
From what I understand, the prednisone itself exits your system pretty quickly. The withdrawal symptoms however hang around for quite a bit longer and the body has to re-balance and start producing adequate cortisone for itself once again. Not to mention re-balancing your Salt and Potasium levels.

As for your other questions - here's my take :-)

* Is it because my body is still adjusting without the Prednisone?
I'd be saying yes - I just came off pred 5 weeks ago and am still getting muscle and joint aches in my shoulders and lower back.

* Is it because I might be fighting a cold or sickness or even the drastic weather changes?
I was warned that its easier to get sick and you can stay sick longer when you come off Pred. This was certainly the case with me. I got a cough that turned really nasty and I am just shaking it off 4 weeks later. Mind you, I didn't use antibiotics as I was not willing to risk pushing myself back into flare after just starting to exit one.

* Is it because my workouts have been to intense?
I had to stop working out and had to reduce my pool laps when swimming as I found the more exericise I did, the more sore I felt and the more I experienced extreme weakness and tiredness. My Theory - Exercise causes normal body infamation. Cortisone (the chemical the adrenal glands has to start producing again) is lower then the average person because the body is still recovering from Pred withdrawal. Hence, there isn't enough cortisone to combat the normal inflamation that results from exercise. Just my theory, but it fits in my case.
"We are dreamers, shapers, singers and makers..." - Elric, elder Technomage
    - 2xColazide, twice a day; 1x6-mp twice a day; 1xAbatacept 10mg/kg per month;
    - 1xZinc per day, 2xScoop of Sustagen Sport per day;
    - 1xBIOCeuticals UltraBiotic 45 per day, 1xBIOCeuticals SB FlorActiv per day;
    - 1xHeaped teaspoon of Metamucil smooth orange powder 3 times a day.

Regular Member

Date Joined Jan 2008
Total Posts : 27
   Posted 1/16/2008 12:09 AM (GMT -6)   
A couple weeks after I got off prednisone my colitis starting getting worse but didn't have any other effects. Going for a sigmoidoscopy soon to see where to take things from here.
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