rectal steroid = oral pred?

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jayce
Regular Member


Date Joined Nov 2007
Total Posts : 382
   Posted 1/9/2008 6:58 PM (GMT -7)   
when we lay it all out, my daughter may not be taking oral steroids, but it seems that she might as well-the dr told me her aim was to keep her off them, but with all of the rectal meds she is ingesting quite a bit. is there a difference once they start entering the blood stream? it is my understanding that 10% of each of the rectal meds are absorbed and she is using 3 differenr rectal meds with cortisonethanks
Mom to 19 year old daughter diagnosed 11/07.
asacol 2 3x daily-discontinued
colazal 3 3x daily/switched to 4 4x daily
proctofoam 3x daily/1-2xdaily
mesalamine enema 1x daily
canasa suppostiories 3x daily /switched to court supp 1-2x daily
culturelle probiotic 1 daily/switched to danon activiea?
chewable vitamin
hydrocortisone enema at bed time

Post Edited (PLEASE) : 1/9/2008 7:01:05 PM (GMT-7)


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 1/9/2008 7:37 PM (GMT -7)   
You don't get near the amount of steroid in your system via the rectal meds compared to taking them orally, not near....I've been on cortifoam for as long a one full year BEFORE tapering off and never had a single side effect from it. Pred doesn't compare to steroid rectal meds.

:)
My bum is broken....there's a big crack down the middle of it!  LOL  :)


KSpace
Regular Member


Date Joined Jan 2008
Total Posts : 72
   Posted 1/9/2008 8:50 PM (GMT -7)   
According to my doctor, absorption from the colon depends upon the degree of inflammation. Since inflammation brings along increased blood flow, the greater the inflammation, greater the blood flow. With this increased blood flow comes diffusion of the medicine into the systemic circulation. The doctor says that "maximum" absorption would be 50% in the severest case of inflammation. Depending on the total dose of the rectal steroids (i.e. I'm taking 100 mg / 60 mL in the Cortenemas), there still could be a significant amount of systemic absorption. 50% of 100 mg is still 50 mg of hydrocortisone! There are of course a lot of variables, including inflammation, how long the enema is retained, how much of the enema is actually inserted. Just my thoughts. Hopefully your daughter doesn't experience any side effects! Good luck.
15 cm left sided colitis
currently on a trial of cortenemas, and that's all!
keeping my fingers crossed

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