It sounds like you're allergic to 5-ASA meds so I would doubt that Dipentum would be any better for you than the 5-ASAs you've already tried. Dipentum 1st came on the market in the 1990s; my gastro wanted me to use it as a maintenance med because Asacol did not agree with me. Dipentum did help me somewhat, but I took it at lower than recommended daily dose, due to continuing D. In short, it helped to control my inflammation, but it seemed to perpetuate D! When Colazal reached Phase 2 of NIH clinical trials my gastro prescribed it for me with a comment that it was an improvement over Dipentum "because Dipentum perpetuated D". In other words, gastros had gotten many complaints like mine about
Dipentum that were not acknowledged until Colazal became available!
What you can use in place of mesalamine enemas are the steroids, budesonide or hydrocortisone. / Old Hat (nearly 30 yrs with left-sided UC; currently on 3 Colazal daily for maintenance of remission)