Thoughts on Dipentum

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betsaronie
Regular Member


Date Joined Oct 2007
Total Posts : 318
   Posted 1/9/2008 8:44 PM (GMT -7)   
I just started with another new GI (my 3rd in one year!) and she wants me to try Dipentum. I've never heard of this drug before, but i looked it up and know that is part of the 5-ASA group with the same type of side effects. So far every drug i've tried has made me worse so I'm hesitant to try anything new. After my recent stay in the hospital i was put on 40mg of pred and had no bleeding or d within 2 days and was feeling great. Then my last dr had me try colazal and it caused me to bleed more than i ever have before and I haven't quite recovered from that yet. I'm afraid that if i have a bad reaction to Dipentum that the progress I've made in the last month towards no more blood will all be gone and i'll be back where i started. Is it worth trying anyway? To those who have tried it or currently use it, what's been your experience with it?
diagnosed with UC Dec 2006 at 22
diagnosed with IBS at 15
5mg prednisone
1000mg of Curcumin twice a day, probiotics, fish oil-3,6,9, coral calcium, multivitamin, yellowdock, iron, mangosteen juice, aloe vera gel
allergic or intolerant to all 5ASAs and 6-mp


julee70
Regular Member


Date Joined Oct 2007
Total Posts : 486
   Posted 1/10/2008 2:40 AM (GMT -7)   
I gave DiPentum a try. That "try" lasted nearly a year, I think! I stayed on in for a while because it appeared to work in the beginning far more than Asacol or Colazal had for me. But after a while, I was flaring all the time and it wasn't helping at all.

This is a tough call. If 5ASA drugs have always made you worse, I can definitely see why you'd be hesitant to try this. I would be too. On the other hand, all the 5ASA drugs are slightly different from one another and maybe this one would work. I'm a bit skeptical about that possibility, but maybe your doctor can make a strong case for trying it.

It might be helpful to ask your doctor what she would do if the DiPentum doesn't work. Maybe if you weigh the option of trying the DiPentum against the next option it might seem clearer whether it's worth the risk.

Do you have the same intolerance of Rowasa enemas or Canasa suppositories? Have you tried Cortifoam (rectal steroid foam) for flares?
-------
UC for the last ten years
Current Meds: 6MP
Past Meds: You name it; I've tried it.


betsaronie
Regular Member


Date Joined Oct 2007
Total Posts : 318
   Posted 1/10/2008 6:34 AM (GMT -7)   
thanks for your input! It seems that my dr believes my next option is remicade or humira and because of my insurance situation i cannot afford those treatments, plus i don't believe the risks outweigh the benefits for those drugs.
I have an intolerance to mesalamine which is why my drs so far have not tried the rowasa. I had difficulty breathing and extreme cramping and constipation while taking casana (it was the first drug i ever tried.)
I have tried cortifoam and thankfully no side effects, but it didn't alleviate my symptoms at all. I was wondering if maybe i should try it again though. At least i know it won't make me worse right :)
I did achieve a 5 month remission with only natural supplements. I flared again when i began school and got sick and couldn't get better. Plus the stress of it being my last quarter before graduating didn't help.
Are there any enemas or suppositories besides the cortifoam that aren't mesalamine based? I know i'm allergic to sulfa so any of those are out as well.
diagnosed with UC Dec 2006 at 22
diagnosed with IBS at 15
5mg prednisone
1000mg of Curcumin twice a day, probiotics, fish oil-3,6,9, coral calcium, multivitamin, yellowdock, iron, mangosteen juice, aloe vera gel
allergic or intolerant to all 5ASAs and 6-mp


Old Hat
Veteran Member


Date Joined Feb 2007
Total Posts : 5135
   Posted 1/10/2008 8:19 AM (GMT -7)   
It sounds like you're allergic to 5-ASA meds so I would doubt that Dipentum would be any better for you than the 5-ASAs you've already tried. Dipentum 1st came on the market in the 1990s; my gastro wanted me to use it as a maintenance med because Asacol did not agree with me. Dipentum did help me somewhat, but I took it at lower than recommended daily dose, due to continuing D. In short, it helped to control my inflammation, but it seemed to perpetuate D! When Colazal reached Phase 2 of NIH clinical trials my gastro prescribed it for me with a comment that it was an improvement over Dipentum "because Dipentum perpetuated D". In other words, gastros had gotten many complaints like mine about Dipentum that were not acknowledged until Colazal became available!
What you can use in place of mesalamine enemas are the steroids, budesonide or hydrocortisone. / Old Hat (nearly 30 yrs with left-sided UC; currently on 3 Colazal daily for maintenance of remission)
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