Can anyone else see the signifigance in this?

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Harpo
Regular Member


Date Joined Jul 2007
Total Posts : 262
   Posted 1/10/2008 11:04 AM (GMT -7)   
Alzheimer's affects 700,000 Britons
A drug used for arthritis can reverse the symptoms of Alzheimer's "in minutes".

It appears to tackle one of the main features of the disease - inflammation in the brain.

The drug, called Enbrel, is injected into the spine where it blocks a chemical responsible for damaging the brain and other organs.

A pilot study carried out by U.S. researchers found one patient had his symptoms reversed "in minutes".

Other patients have shown some improvements in symptoms such as forgetfulness and confusion after weekly injections over six months.

The study of 15 patients with moderate to severe Alzheimer's has just been published in the Journal of Neuroinflammation by online publishers Biomed Central.

The experiment showed that Enbrel can deactivate TNF (tumour necrosis factor) - a chemical in the fluid surrounding the brain that is found in Alzheimer's sufferers.

When used by arthritis sufferers, the drug is self-administered by injection and researchers had to develop a way of injecting it into the spine to affect the brain cells.

Sue Griffin, a researcher at the University of Arkansas for Medical Sciences, said: 'It is unprecedented to see cognitive and behavioural improvement in a patient with established dementia within minutes of therapeutic intervention.

'This gives all of us in Alzheimer research a tremendous new clue

about new avenues of research.' Enbrel is not approved for treating Alzheimer's in the U.S. or the UK and is regarded as highly experimental, said Dr Griffin.

'Even though this report predominantly discusses a single patient it is of significant scientific interest because of the potential insight it may give into the processes involved in the brain dysfunction of Alzheimer's,' she added.

Lead author of the study Edward Tobinick, of the University of California and Director of the Institute for Neurological Research, said the drug had 'a very rapid effect that's never been reported in a human being before'.

He added: 'It makes practical changes that are significant and perceptible, making a difference to his daily living.

'Some patients have been able to start driving again. They don't come back to normal but the change is good enough for patients to want to continue treatment.'

He said top-up injections were necessary but some patients had them a month apart.

Alzheimer's is the most common cause of dementia, affecting more than 700,000 Britons with about 500 cases diagnosed every day.

Neil Hunt, of the Alzheimer's Society charity, said: 'The pursuit of a miracle cure for Alzheimer's continues to drive research into a variety of potential treatment targets.

These include a possible link between inflammatory reactions in the brain and Alzheimer's.'

Children exposed to lead in old paint, Victorian pipes and toys could be at risk of Alzheimer's later in life, scientists said yesterday.

A study shows that even small amounts of the metal in the first few years can build up plaques around the brain.

Scientists at the University of Rhode Island told the New Scientist that they fed infant formula milk laced with low doses of lead to baby monkeys, then followed their progress for 23 years. A post mortem of the brains revealed plaques - harmful deposits of protein found in Alzheimer's patients.
Male 36yrs old. Indeterminate Colitis 6 yrs.


Pro-bio

Protonix
multi vitamin


princesscolon
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Date Joined Apr 2006
Total Posts : 733
   Posted 1/10/2008 11:24 AM (GMT -7)   
I am not sure what you mean, are you saying how Enbrel might be a treatment for UC? It is being studied for it right now as far as I know.
Diagnosed with Left-sided Ulcerative Colitis 1995 at 15
Tried: Prednisone, Rowasa & Hydrocortisone Enemas, Proctofoam, Sulfasalazine, Asacol, Probiotics, Fish Oil, Canasa, Enotcort, Colazol, Proctocort, Anamantle, etc...
Diagnosed with Ulcerative Proctitis with almost rectovaginal fistula in 2004, put on Remicade, August 2007:Increased Remicade dosage-700mg every 6 weeks,diagnosed with Psoriatic Arthritis & Fibromyalgia Current meds: Remicade 700mgs every 6 wks (had reaction, will start Humira Jan 29) Clorazepate, Proctofoam HC, Glucosamine 500, Vitamin B, Lomotil as needed, Darvocet, Tylenol pm


Beth75
Veteran Member


Date Joined Jul 2007
Total Posts : 2148
   Posted 1/10/2008 12:00 PM (GMT -7)   
very interesting. I think that would be great if that became a new option for us!
Beth, 32
Major Flare Sept/Oct 07 ~ working on remission almost there
UC Diagnosed March 2000 (30 cenitmeters)
Azathioprine 200mg 1xday nightly; Calcium and Vit D 500mg 3xday, Multi Vit, Folic Acid 400mg 2xday, Probiotics.
Minimal Change Disease (Kidney Disorder) Diagnosed Sept 2007
Prednisone 60/40mg alt days 1xday, Simvastatin 20mg 1xday, Diovan 160mg 2xday. Potassium 600mg 2xday, Fosomax 70mg 1xweek. MCD may be from hypersensitivty to 5ASA drugs.


Eva Lou
Veteran Member


Date Joined Sep 2006
Total Posts : 3437
   Posted 1/10/2008 12:15 PM (GMT -7)   
I'm pretty sure it's in clinical trials right now. It's basically the same as Remicade, Humira, etc- a biologic.

diagnosed with UC '02
meds-
Asacol- 8 tabs/day
Remicade infusions
Imuran- 100mgs/day
Prednisone- 10mgs/day
 


MitzMN
Veteran Member


Date Joined Feb 2007
Total Posts : 622
   Posted 1/10/2008 2:13 PM (GMT -7)   
Inflammation, inflammation, inflammation. The body's inflammatory response appears to absolutely wreak havoc on the body and seems to play a role in so very many illnesses and maladies. How can we control the inflammatory response????? It might be the ticket to better health for everyone!

Mitz
Sporadic proctitis since about 1985. Mother had J-pouch surgery 1983.
DX'd with clostridium difficile in 2000. Pred, two courses of Flagyl, then Vancomycin finally got rid of it. 2001 colonoscopy dx'd left-sided UC. . Treated with prednisone, Rowasa, Asacol. Asacol not working, switched to Imuran. Three small flares since in 2002, 2005, and 2007, brought under control with steroid and Rowasa enemas. Lap Chole performed October 26, 2007, after gall bladder attack in June, '07.
Daily meds: 100 mg Azathioprine and 225 mg Effexor XR (for chronic, longstanding depression), many vitamins and Primadophilus Reuteri


tjf
Veteran Member


Date Joined Dec 2005
Total Posts : 3238
   Posted 1/10/2008 2:15 PM (GMT -7)   
Hey. Remember if possible just to do a link instead of cutting and pasting research article. Thanks!
Tabitha (Tab)

100mg Azathioprine, 2 Fibercon, Colazal-9 a day, Acidopholis Pearls, Nexium

http://www.healingwell.com/donate
Co-Moderator UC Forum


dakotagirl
Veteran Member


Date Joined Apr 2006
Total Posts : 3402
   Posted 1/10/2008 6:35 PM (GMT -7)   
I have seen commercials for Enbrel and RA. Since Remi and Humira both started out as RA treatments, I've been wondering if it would work for UC.
Pan-colitis and GERD diagnosed May 2003
 
Asacol 12 per day,  Azathioprine 75mg, Aciphex, Effexor XR, Forvia and a Probiotic
Osteopenia (hip and spine) from prednisone use.  Started Azathioprine because I was steroid dependent.
 
Co-Mod for the UC forum
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Harpo
Regular Member


Date Joined Jul 2007
Total Posts : 262
   Posted 1/14/2008 7:07 AM (GMT -7)   
tjf said...
Hey. Remember if possible just to do a link instead of cutting and pasting research article. Thanks!


Whats wrong with posting an article? It is a forum you know.

Off site links are bad.. Unless they're being used to generate income.

As far as server space go's, an article is nothing in terms of bytes.

Anyway, to those that commented.. I agree, inflammation is bad.
Male 36yrs old. Indeterminate Colitis 6 yrs.


Pro-bio

Protonix
multi vitamin


Sideshowbob
Veteran Member


Date Joined Sep 2005
Total Posts : 698
   Posted 1/14/2008 10:53 AM (GMT -7)   
Harpo, what Tabitha was politely reminding you of is a rule of the forum:

9. No posts of lengthy articles. Sharing information is allowed, but the forums are not to be used to publish articles. It is an improper use of critical forum resources.

If you have a problem with one of the rules of the forum, take it up with the administrator.
35 year old Male, Husband, Father of the best three kids in the universe.
First Flare was February 2005. Diagnosed June 2005-left-sided Colitis, suspect it has since spread. Started 4000 mg Oral Salofalk June 2005-stopped January 2007. Remission until November 2006. Been in a flare to various degrees since November 2006 to February 2007. Currently in remission.
Presently on 0 mg Prednisone-down from 60 mg!
Weekly 4000 mg Salofalk enemas.
Daily 4000 mg Salofalk oral.
Started Omeprazole 20 mg February 2007.
Co-Moderator-UC Forum

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