Has any one taken Flagyl or Levaquin for UC?

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New Member

Date Joined Dec 2007
Total Posts : 13
   Posted 1/11/2008 12:35 AM (GMT -6)   
     I've been on prednisone and Asacol since 11/6/07 and at first it worked really well my symptoms were 50% better.
Then, they would get a little worse, then a little better and finally they got worse and stayed that way.  My doctor decided to put me on Flagyl and Levaquin along with my other meds and told me to use my colocort enema twice a day instead of once.  I've been reading about FLagyl and don't like what I've read, has anyone else been treated with it for UC?  She said if this doesn't work we might try Remicade and from what I read on the postings to Red I don't know if I really want that.

Trixy's Got Butt Trouble
Regular Member

Date Joined Jun 2007
Total Posts : 356
   Posted 1/11/2008 9:31 PM (GMT -6)   
I believe Flagyl is a type of antibiotic. I was on it twice for my UC, but it was only a short course each time. How long is your Doc keeping you on them?
Best Wishes,
Trixy (39)
dx Pancolitis, mild, w/more activity on left side & IBS
12 Asacol a day;
1 Rowasa at night during flare/1 a week during remission;
Nexium; Probiotic; Multi-Vitamin; Flax Seed Oil
UC manifesting to other organs: joints, eyes (Iritis) & skin (Erythema Nodusom)
Controlling w/MEDS & DIET (eliminating animal protein, white flour, sugar, dairy, eggs, & nightshade veggies)
Current Status:  12/22/07 Ending 2 month flare & heading into remission - no blood, D or other symptoms since 12/22/07 :-)  Keeping fingers crossed!

Regular Member

Date Joined Oct 2007
Total Posts : 318
   Posted 1/11/2008 10:15 PM (GMT -6)   
i was on a flagyl IV (and levaquin) the first time i had to go to the hospital for UC and it worked fine for me that way. (they are both antibiotics) I unfortunately cannot tolerate it as a pill, it gives me massive gallbladder pains. I would think if your dr plans on a short course it should be ok. It really helped me get better quickly. But I'm with you on not really liking what happens with most medicine as far as side effects go. My guess is your dr is trying to avoid you needing to get them intravenously by starting you on the pills. I'd say try it for at least a week or so and maybe you'll get better. if not consider stopping if you don't like the risks involved. ultimately it's your decision, not your dr's.
diagnosed with UC Dec 2006 at 22
diagnosed with IBS at 15
5mg prednisone
1000mg of Curcumin twice a day, probiotics, fish oil-3,6,9, coral calcium, multivitamin, yellowdock, iron, mangosteen juice, aloe vera gel
allergic or intolerant to all 5ASAs and 6-mp

Regular Member

Date Joined Nov 2006
Total Posts : 190
   Posted 1/11/2008 10:46 PM (GMT -6)   
Cipro has helped me out in the past. It's definitely not a maintenance medication though.

Veteran Member

Date Joined Apr 2006
Total Posts : 733
   Posted 1/12/2008 8:55 AM (GMT -6)   
I have taken Flagyl several times and I felt it helped me feel a little better and I never noticed any side effects. It is one of the only meds I can say that about, I guess it just works for my body for some reason.
Diagnosed with Left-sided Ulcerative Colitis 1995 at 15
Tried: Prednisone, Rowasa & Hydrocortisone Enemas, Proctofoam, Sulfasalazine, Asacol, Probiotics, Fish Oil, Canasa, Enotcort, Colazol, Proctocort, Anamantle, etc...
Diagnosed with Ulcerative Proctitis with almost rectovaginal fistula in 2004, put on Remicade, August 2007:Increased Remicade dosage-700mg every 6 weeks,diagnosed with Psoriatic Arthritis & Fibromyalgia Current meds: Remicade 700mgs every 6 wks (had reaction, will start Humira Jan 29) Clorazepate, Proctofoam HC, Glucosamine 500, Vitamin B, Lomotil as needed, Darvocet, Tylenol pm

Veteran Member

Date Joined Dec 2007
Total Posts : 536
   Posted 1/12/2008 5:04 PM (GMT -6)   
Flagyl caused the 4-month flare I just recovered from. It is a very harsh med with lots of side effects including numbness, depression, you name it. Some say it helps, it took me to rock bottom.
21 years of UC which started after quitting smoking. In and out of flares which are usually triggered by antibiotics.
  • Salofalk enemas each 2nd day
  • 8 500mg Pentasa a day
  • Probiotic
  • Psyllium powder.

New Member

Date Joined Dec 2007
Total Posts : 13
   Posted 1/12/2008 8:10 PM (GMT -6)   
Thanks everyone for your input, you guys are great. Well, right now I'm on Asacol, Levaquin, and Flagyl. The only med I had never taken before three days ago was flagyl. Yesterday my trips to the bathroom doubled and today the cramping has been so bad I've been curled up in the fetal position. Oh, I think I might be allergic to it, I got these blister-zit looking things on my arms and they hurt, but so far I don't see them anywhere else. I'm thinking about calling my doctor what do you guys think?
I'm only suppose to be on a short dose but man the side effects are bad.
Diagnosed UC 11/9/07, ApL 5/11/98, Lupus 2000
Asacol 400mg 4 pills 3xday, Prednisone 20mg 2xday, Elavil, multi-vitamin, calcium, pro-biotic, colocort enema twice daily, cymbalta, prevacid, Levaquin, Flagyl

Veteran Member

Date Joined Apr 2006
Total Posts : 3402
   Posted 1/12/2008 10:10 PM (GMT -6)   
Yes - call your doctor! New things like that shouldn't be ignored.
Pan-colitis and GERD diagnosed May 2003
Asacol 12 per day,  Azathioprine 75mg, Aciphex, Effexor XR, Forvia and a Probiotic
Osteopenia (hip and spine) from prednisone use.  Started Azathioprine because I was steroid dependent.
Co-Mod for the UC forum
Keep HealingWell running smoothly:  www.healingwell.com/donate

Regular Member

Date Joined Jan 2006
Total Posts : 187
   Posted 1/12/2008 11:36 PM (GMT -6)   
My GI had me on Flagyl for a couple of months. I did nothing for me so she had me stop.

Veteran Member

Date Joined Mar 2007
Total Posts : 4509
   Posted 1/12/2008 11:46 PM (GMT -6)   
Yeah, call your doctor. I hate Flagyl....made me feel really crappy. Headaches, horrible taste in my mouth, dizzy. I can't remember what else, but I remember thinking "I am never, ever taking this again."

Are you supposed to be on this long-term? I think Old Hat has posted previously that taking Flagyl long-term is not recommended because of the potential for some serious side effects.
23 years old
Diagnosed with UC March 2007; yet to go into remission
Asacol 4 tablets 3x/day
Rowasa (generic) - daily
Nature's Way Primadophilus Reuteri 1/day; Chewable multivitamin; Metamucil; Viactiv (Calcium and Vit. D); fish oil

Regular Member

Date Joined Jun 2006
Total Posts : 173
   Posted 1/13/2008 1:54 AM (GMT -6)   
I took Flagyl. Did not like it at all. First of all it's a huge pill and has a horrible metallic taste. made me want to gag every time i took it. anyway, i think i had a bad reaction to it because there was some nerve damage in my feet for awhile. for like a month my feet felt like they were asleep 24/7. it got so bothersome that i went to a neurologist and he gave me Neurontin, which made it go away. my doctor took me off Flagyl.
Age 17

Diagnosed September '01
Remission since July '02

Asacol- 4 pills 3xday
Azathioprine- 75mg 1xmorning
Took Remicade 3 times, BIG FAN!!!!

Veteran Member

Date Joined May 2006
Total Posts : 1177
   Posted 1/13/2008 7:14 AM (GMT -6)   
My husband took Flagyl when they weren't sure if his diarrhea was caused by UP or by some parasite like Giardia. It made him so much worse. He had horrible cramping, and his need to use the bathroom because of the cramping and the bowel wanting to empty itself, went up from like 3-6 times a day to about 30.

Later, I had to try flagyl during travel to Mexico, and boy, I almost passed out from the severe cramping it caused. I had to go to a local doctor and get a substitute for flagyl (metronidazole) called tinidizole (not yet approved for use in the US, but is used widely in the rest of the world and by the US military), which had much less severe side effects than flagyl.

If you think your symptoms have gotten worse after you started flagyl, in my personal experience, that could be _because_ of the flagyl (as a side effect), not because your UC is getting worse.
Husband with Ulcerative Proctitis
Diagnosed March 2003, 1st Flareup after diagnosis Apr 2006
Currently in Remission
Nightly 1000mg time release Canasa
Even though he has no symptoms, he's on VSL # 3 (1 packet daily) for prevention
Was on the SCD, but we stopped after 4 months of no symptoms - he's doing fine on a normal diet

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