do you have confidence in 5-ASAs?

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UCinNC
Veteran Member


Date Joined May 2007
Total Posts : 528
   Posted 1/15/2008 9:51 AM (GMT -7)   
Hi. I am having constant, low-level problems. Going to work, some days still exercising, but on and off lots of nauseous and urgency and frequency. I have a conservative GI (which I appreciate), so he is trying to address the issue piece by piece so I can stay off pred and not increase my Imuran (since I am totally exhausted most days). so, today he has switched me off Asacol to Colazal for 3 reasons.
1. not clear asacol is actually doing anything for me
2. asacol could be the cause of my nauseous
3. good starting place (as opposed to pred or more imuran)

so, I am just wondering, have any of you had success switching off asacol to colazal? I am switching from 12 asacol a day to 9 colazal a day. thanks.
29/Female/NC
Pancolitis dx 3/07
12 Asacol/day
150mg Imuran/day (steroid dependent, reached this dose 9/07)
Various vitamins, a probiotic.


quincy
Elite Member


Date Joined May 2003
Total Posts : 29860
   Posted 1/15/2008 10:10 AM (GMT -7)   
Of course, I'm hardcore 5ASA..oral and rectal for 19 years, so I would say I have the utmost confidence in it. As well, my last c-scope was awesome, so I do believe it has something to do with that.

Why are you not on any rectal meds?

quincy
*Heather*Status: mini flare Dec 28... increased enemas to nightly
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....bromelain 1 - 2x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!


Red_34
Forum Moderator


Date Joined Apr 2004
Total Posts : 23549
   Posted 1/15/2008 11:18 AM (GMT -7)   
I have some confidence in 5-ASA's - maybe not for me personally but for many here on this site. The only 5-ASA that I can take and tolerate is Colazal. I switched from Asacol (12 a day) to 9 Colazal with success.
 @--->--SHERRY--<---@
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc -'92 - Colazal (9 daily), 6mp (50-100mgs), Colocort, Prilosec, Biotin, Forvia, Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa** ~Allergies - Allegra & Singulair
~Secondary Reynauds Syndrome - '04 - Norvasc~Fibromyalgia - '06~No meds
To help Healingwell - click here: DONATE
http://www.myspace.com/82595818
"The quality of my life depends on the quality of my thoughts."
 
 
 
 

 
 


Old Hat
Veteran Member


Date Joined Feb 2007
Total Posts : 5136
   Posted 1/15/2008 11:29 AM (GMT -7)   
Yup-- I have the most confidence in Rowasa for treatment of UC proctosigmoiditis. Next most in Colazal because it keeps my descending colon in remission, too! (Though I cannot take it at full daily dose for more than 10 weeks w/o side effects.) Asacol did not help me at all; Dipentum helped somewhat but perpetuated D. It might indeed help you to switch to Colazal: seems worth a try! / Old Hat (nearly 30 yrs with left-sided UC; currently on 3 Colazal daily for maintenance of remission)

princesa
Veteran Member


Date Joined Aug 2007
Total Posts : 2198
   Posted 1/15/2008 11:33 AM (GMT -7)   
Asacol has adverse effects for a lot of folks, so it's certainly worth experimenting with other ASAs. I began to improve when I was switched from Asacol to the older azulfadine.
Diagnosed with ulcerative colitis spring 1999
 
Therapeutic dose sulfasalazine.
Probiotics, l-glutamine and fish oil caps. George's aloe vera juice and Mucosaheal.
 
 


Severin
Regular Member


Date Joined Oct 2007
Total Posts : 320
   Posted 1/15/2008 11:47 PM (GMT 0)   
I am a HUGE fan of Colazide (known as Colazal in the US). This 5-ASA based on Balsalazide made a massive difference for me. I was taking Salofalk and things were just getting worse by the day.

The Story:
Went on holiday to Thailand, ran out of Salofalk. Still had Colazide, so was taking Colazide without the Salofalk. Things started to get noticably better after a week or so. Got back to Australia, thought it was just because I had been on holiday. Got more Salofalk and things started to get worse again.

Have since dumped the Salofalk and am just taking Colazide and I believe it really helps.

Colazide is great because it only releases the 5-ASA (mesalazine) once it makes it into the large intestine, unlike many of the other 5-ASA drugs.
"We are dreamers, shapers, singers and makers..." - Elric, elder Technomage
    - 2xColazide, twice a day; 1x6-mp twice a day; 1xAbatacept 10mg/kg per month;
    - 1xZinc per day, 2xScoop of Sustagen Sport per day;
    - 1xBIOCeuticals UltraBiotic 45 per day, 1xBIOCeuticals SB FlorActiv per day;
    - 1xHeaped teaspoon of Metamucil smooth orange powder 3 times a day.


quincy
Elite Member


Date Joined May 2003
Total Posts : 29860
   Posted 1/16/2008 12:46 AM (GMT -7)   
princesa said...
Asacol has adverse effects for a lot of folks, so it's certainly worth experimenting with other ASAs. I began to improve when I was switched from Asacol to the older azulfadine.

Clarification.. because it's very important.  It's  5-ASA (5- aminosalicylic acid)...
not ASA ( acetylsalicylic  acid)..totally different.
just being "anal".
q
 
 



*Heather*Status: mini flare Dec 28... increased enemas to nightly
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....bromelain 1 - 2x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!


damo123
Veteran Member


Date Joined Jul 2007
Total Posts : 713
   Posted 1/16/2008 3:15 AM (GMT -7)   
Do I have confidence in them? No. I do not think Asacol has done much for me. I have a bit more confidence in the Asacol suppositories. And I believe that Asacol did give me some nausea though that seems to be now gone.

Diet and a stress-free life are for me an empirical diety compared with the dubious-virtue I associate with Asacol.

D


800 mg Asacol a day
500 mg Asacol suppository now and then!
Fibre supplement, Iron supplment,Probioitcs
Balanced Diet, Reduced Stress
 
"There is no greater tragedy in life than doing nothing for fear of doing too little. May you live all the days of your life."
 
 
 
 
 
 
 

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