Researchers may have found a potential IBD cure

New Topic Post Reply Printable Version
41 posts in this thread.
Viewing Page :
 1  2 
[ << Previous Thread | Next Thread >> ]

dakotagirl
Veteran Member


Date Joined Apr 2006
Total Posts : 3402
   Posted 1/16/2008 8:02 AM (GMT -6)   
 
I'm not holding my breath, but I'm keeping my hopes up!
Pan-colitis and GERD diagnosed May 2003
 
Asacol 12 per day,  Azathioprine 75mg, Aciphex, Effexor XR, Forvia and a Probiotic
Osteopenia (hip and spine) from prednisone use.  Started Azathioprine because I was steroid dependent.
 
Co-Mod for the UC forum
Keep HealingWell running smoothly:  www.healingwell.com/donate


Scottishcammy
Regular Member


Date Joined Nov 2007
Total Posts : 124
   Posted 1/16/2008 8:05 AM (GMT -6)   
 
**Just made your links active :)

Post Edited By Moderator (dakotagirl) : 1/16/2008 7:33:59 AM (GMT-7)


Scottishcammy
Regular Member


Date Joined Nov 2007
Total Posts : 124
   Posted 1/16/2008 8:07 AM (GMT -6)   
 

Post Edited By Moderator (dakotagirl) : 1/16/2008 7:34:12 AM (GMT-7)


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 1/16/2008 10:43 AM (GMT -6)   

On the last link posted by scottishcammy it's dated 2006 yet in this link here.....

http://www.medicalnewstoday.com/articles/93942.php

it's dated a few days ago...strange because this is the first I've heard of this potential cure for IBD so I wonder why the one is dated from 2006.

 

:)


My bum is broken....there's a big crack down the middle of it!  LOL  :)


love4cats
Regular Member


Date Joined May 2007
Total Posts : 458
   Posted 1/16/2008 10:58 AM (GMT -6)   
Is this only for leaky gut? Never heard that leaks into the intestines from the stomach causes IBD?
 
 
Dx:  UC Proctitis 2006
 
Meds:  None so far. Garlic works to ease flares. My GI laughed when I told him and said it was just coincidence.
 
Diet:  Regular fresh garlic, Biobest yogurt daily, Omega 3 supplements, very limited junk food, carbs and processed food, low fat diet.  Lots of fresh fruit and veggies (limited potatoes). 
 
Added: tumeric and probiotics.
 
 


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 1/16/2008 11:02 AM (GMT -6)   
Inflamed Gut Lining because of Leaky Gut Syndrome
When the gut lining is inflamed the protective coating of lgA (immunoglobulin A) is negatively affected. The body is unable to ward off bacteria, viruses and parasites as well as fungus and yeasts like Candida. These pathogenic bad organisms then pass from the gut cavity into the bloodstream and set up infection anywhere else in the body.

Formation of Antibodies with Leaky Gut Syndrome
Formation of antibodies may occur. They leak across and look similar to antigens on our own tissues. So when an antibody is made to attack it, it also attacks the tissue. This is possibly how auto-immune and chronic disease like Crohn's Disease, Rheumatoid arthritis, Lupus, Multiple Sclerosis, and Thyroiditis start.

And as stated in the link I posted....

"Under normal conditions our gastro-intestinal tract is lined with cells that block the contents of the gut from leaking into the intestine," explains Professor Cormac Taylor from the UCD Conway Institute, University College Dublin, one of the principal scientists involved in the discovery. "However, when a person is suffering from IBD this barrier is broken and the contents of the gut leak out into surrounding areas."

"When we applied the new drugs, the gut was tricked into thinking that it was being deprived of oxygen and this activated protective pathways which in turn prevented the death of the cells that line the gastrointestinal tract," continues Professor Taylor.

:)


My bum is broken....there's a big crack down the middle of it!  LOL  :)


UCinNC
Veteran Member


Date Joined May 2007
Total Posts : 528
   Posted 1/16/2008 12:03 PM (GMT -6)   
my fiance is Irish and went to UCD, and now does biomedical stuff at Duke. we were just talking about this article yesterday. we were both excited because of its potential as an alternative to drugs that interrupt or weaken the immune system. here's to keeping fingers crossed.
29/Female/NC
Pancolitis dx 3/07
9 Colazal a day (used to be on 12 Asacol, don't think Asacol helped)
150mg Imuran/day (steroid dependent, reached this dose 9/07)
Various vitamins, bit of fish oil, a probiotic.


*Jen*
Veteran Member


Date Joined Jul 2005
Total Posts : 514
   Posted 1/16/2008 12:32 PM (GMT -6)   
The 2006 article said that it was a 2 year test, so maybe that is why. They started it in 2006 and have completed it and released the results. Wow...this really made my day!!! Do you really think this could mean some serious change for us??? I am so excited.
Diagnosed: 
Officially Diagnosed with UC in June 2003.  Have had stomach issues since 1989.  Unknown if they are related or not.  Have mild/moderate UC.  Have had 4 flares, the last one caused by hormones from stopping breastfeeding.  Currently back in remission!  Only taking 6 Asacol a day.   Will take Rowasa enemas as needed. Colozal did not work for me.  Luckily my UC is relatively minor and responds well to meds, but man do those flares hurt!
 
 


UCinNC
Veteran Member


Date Joined May 2007
Total Posts : 528
   Posted 1/16/2008 12:45 PM (GMT -6)   
I wouldn't get too hopeful too quickly. Even if this were to go somewhere, there is a big difference between approval for use in Europe and getting it through the US's FDA. I am not saying it wouldn't happen. I am just saying it would take a handful of years, at least. Would have to go through the three stages of clinical trials here, which takes awhile, I believe.
29/Female/NC
Pancolitis dx 3/07
9 Colazal a day (used to be on 12 Asacol, don't think Asacol helped)
150mg Imuran/day (steroid dependent, reached this dose 9/07)
Various vitamins, bit of fish oil, a probiotic.


damo123
Veteran Member


Date Joined Jul 2007
Total Posts : 714
   Posted 1/16/2008 12:45 PM (GMT -6)   
Leave it to us Irish to solve another one of the world's problem!!!
800 mg Asacol a day
500 mg Asacol suppository now and then!
Fibre supplement, Iron supplment,Probioitcs
Balanced Diet, Reduced Stress
 
"There is no greater tragedy in life than doing nothing for fear of doing too little. May you live all the days of your life."
 
 
 
 
 
 
 


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 1/16/2008 12:46 PM (GMT -6)   
Thanks for clearing that up for me Jen...I often skim when reading (especially when reading the same thing written a little differently) so I clearly missed that.

It definitely sounds like it could have a very positive impact on us IBDers, I just hope this will benefit everyone and not just a percentage of IBD sufferers.

I can definitely imagine having my life back, it seems after almost 17 yrs of dealing with this horrid disease I've spent most of my yrs looking back to how things were, maybe now looking forward is finally going to become a reality.

:)
My bum is broken....there's a big crack down the middle of it!  LOL  :)


*Jen*
Veteran Member


Date Joined Jul 2005
Total Posts : 514
   Posted 1/16/2008 2:07 PM (GMT -6)   
I think there will be a LOT of tourism to Ireland if the US doesn't approve it quickly. = )

I'm seeing my GI tomorrow and will ask her about it...
Diagnosed: 
Officially Diagnosed with UC in June 2003.  Have had stomach issues since 1989.  Unknown if they are related or not.  Have mild/moderate UC.  Have had 4 flares, the last one caused by hormones from stopping breastfeeding.  Currently back in remission!  Only taking 6 Asacol a day.   Will take Rowasa enemas as needed. Colozal did not work for me.  Luckily my UC is relatively minor and responds well to meds, but man do those flares hurt!
 
 


UCinGV
Regular Member


Date Joined Mar 2007
Total Posts : 394
   Posted 1/16/2008 2:16 PM (GMT -6)   
*Jen* said...
I think there will be a LOT of tourism to Ireland if the US doesn't approve it quickly. = )

I'm seeing my GI tomorrow and will ask her about it...

Hey, if this works I'll personally fly to Ireland and give them all a big hug.
12 Asacol
100 mg Imuran


AshNH
Regular Member


Date Joined Jul 2007
Total Posts : 208
   Posted 1/16/2008 3:02 PM (GMT -6)   
This is great. Thanks for the links, all.
Ash 39 NH, vegetarian
Diagnosed with UC July 06 (I think 6/6/6) during 10 day hospitalization
Current meds: Asacol 12, Imuran 150mg
Centrum Silver, Primadophilus Reuteri, DHA-Omega 3, L-glutamine


BalS
Regular Member


Date Joined Mar 2005
Total Posts : 312
   Posted 1/16/2008 3:35 PM (GMT -6)   
Wooooooooooooooooooooooooow, can we actually start dreaming about having a life; stop worrying about our children everytime they have a spot of diarrohea, drop of blood in their stool; think about career development and not UC flares; ...................................

At leaset this gives me a hope that cure at our doorsteps is limited to few years and not decades

Thanks for the links, its really cheered me up and for the first time in my life I can stop worrying about my daughters getting it :-)

Bal
UC - Flare-up since Dec2004
3000iu Vit E Enema
3x3 tablets Colazide 
10mg Predinisolone enema
2  Predfoam - 20mg
Asacol - none now - became immune to them after 2 yrs
 
 
 


marty1976
Veteran Member


Date Joined Nov 2005
Total Posts : 2045
   Posted 1/16/2008 7:46 PM (GMT -6)   
Really exciting stuff. I really hope that this is the breakthrough that cures us all.I'd feel immensely proud if was us Irish found the cure.:):):):)


                                     keep the faith 

         asacol/proctifoam/Zoton (lansoprazole)/propranalol



        http://www.myspace.com/martybuzz1<FONT]


Meesh
Veteran Member


Date Joined May 2006
Total Posts : 619
   Posted 1/16/2008 7:59 PM (GMT -6)   
This sort of thing is why I am so hesitant to commit to the surgery; I'd sure hate to have my colon permanently removed only to have the right drugs finally come down the pipeline. Seems like there's a lot of action happening so I just want to hang in there and be whole when it's ready. Problem is, I am getting close to two years on Prednisone and can't seem to get weaned off of it.

Meesh
Diagnosed UC April 27, 2006
Remicade infusions: 7/21/07; 8/18/07; 10/13/07; 12/15/97;
Lialda, 4 tabs in the morning; Protonix; Prednisone 4/27/06-present, was almost off, back to 40 mg; 12/1/07 - 12/29/07 weekly Venofer (iron sucrose) injections; 9 mg Entocourt EC; Xanax as needed; Lexipro 10 mg, Rowesa; Asacol; Colazal three 750 mg capsules 3X day; Bad reactions: Imuran( 2/07)


Sara14
Veteran Member


Date Joined Mar 2007
Total Posts : 4190
   Posted 1/16/2008 8:22 PM (GMT -6)   
I'm confused...It seems like the headline for that first article ("Experts claim bowel cure") and the information in it is misleading because four other articles I read say the researchers found a "new potential therapeutic approach" or "potential treatment" and that the researchers showed they can "almost completely reverse the symptoms of IBD." Don't get me wrong -- that's great in and of itself -- but do they really think this may be a cure or just another treatment?
23 years old
Diagnosed with UC March 2007; yet to go into remission
Asacol 4 tablets 3x/day
Rowasa (generic) - daily
Nature's Way Primadophilus Reuteri 1/day; Chewable multivitamin; Metamucil; Viactiv (Calcium and Vit. D); fish oil


Scrap Girl
Veteran Member


Date Joined Jan 2007
Total Posts : 653
   Posted 1/16/2008 9:38 PM (GMT -6)   
Sara, I was wondering the same thing. If you Google that institute and click on media, you'll see the press release dated today. And it states that it's a "potential new treatment" for IBD and also that it can "almost completely reverse the symptoms of IBD." I hope it's a "cure."
Diagnosed with UC in Feb. 2005
 
Colazal (9 a day)
Folic Acid
Biotin
Calcium
Remicade remission


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20577
   Posted 1/16/2008 10:25 PM (GMT -6)   
But...don't you think it would be worse if they said, "definite cure" and then it turned out it wasn't?

Hope is much better than nothing, think optimistically...just my 2 cents.

:)
My bum is broken....there's a big crack down the middle of it!  LOL  :)


Sara14
Veteran Member


Date Joined Mar 2007
Total Posts : 4190
   Posted 1/16/2008 11:00 PM (GMT -6)   
There's no difference between saying "cure" and "definite cure." I'm saying that one of the articles said "cure" and the other said a "potential treatment." So, one of them is reporting on the facts incorrectly, and it's confusing. If anyone has a link to the actual published study results, that would be helpful. I couldn't find it myself.


23 years old
Diagnosed with UC March 2007; yet to go into remission
Asacol 4 tablets 3x/day
Rowasa (generic) - daily
Nature's Way Primadophilus Reuteri 1/day; Chewable multivitamin; Metamucil; Viactiv (Calcium and Vit. D); fish oil

Post Edited (Sara14) : 1/16/2008 10:14:02 PM (GMT-7)


BalS
Regular Member


Date Joined Mar 2005
Total Posts : 312
   Posted 1/17/2008 12:05 AM (GMT -6)   
Please can one of the Irish members get in touch with their doctors to get some clear indication if it a cure or treatment.  They tend to have access to real papers and often know the people through the seminars they attend regularly. 
 
BalS
UC - Flare-up since Dec2004
3000iu Vit E Enema
3x3 tablets Colazide 
10mg Predinisolone enema
2  Predfoam - 20mg
Asacol - none now - became immune to them after 2 yrs
 
 
 


damo123
Veteran Member


Date Joined Jul 2007
Total Posts : 714
   Posted 1/17/2008 2:09 AM (GMT -6)   
Dear All,

I'm in Ireland and this has been reported on TV and the newspapers. But there is no extra info I can add that has been released to the media. Also doctors will never speak of the details of a drug to patients that hasn't been through the 7 years of our clinical trials. If this really is a solution to UC then I reckon there's a much better chance of the drug first being released in USA rather than Ireland as from what I've been told FDA approval is faster in the USA. For instance there are many cancer drugs available in the USA but still undergoing testing in Ireland and the UK.

Actually in Ireland the press release said nothing about Coilits. It was released as a potential cure for Crohn's. It has been reported as a "cure" on TV and the newspapers.
800 mg Asacol a day
500 mg Asacol suppository now and then!
Fibre supplement, Iron supplment,Probioitcs
Balanced Diet, Reduced Stress
 
"There is no greater tragedy in life than doing nothing for fear of doing too little. May you live all the days of your life."
 
 
 
 
 
 
 


quincy
Elite Member


Date Joined May 2003
Total Posts : 30587
   Posted 1/17/2008 2:57 AM (GMT -6)   
Cure is the catch word.....who wouldn't listen? It's all reporting and emphasis to make it all the more exciting.

q
*Heather*Status: mini flare Dec 28... increased enemas to nightly
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....bromelain 1 - 2x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!


damo123
Veteran Member


Date Joined Jul 2007
Total Posts : 714
   Posted 1/17/2008 3:04 AM (GMT -6)   
Let's give it a chance Quincy. We know nothing about the big details so let's see what unfolds. The report was by a team of medical doctors so it is they who used the word "cure".

D
800 mg Asacol a day
500 mg Asacol suppository now and then!
Fibre supplement, Iron supplment,Probioitcs
Balanced Diet, Reduced Stress
 
"There is no greater tragedy in life than doing nothing for fear of doing too little. May you live all the days of your life."
 
 
 
 
 
 
 

New Topic Post Reply Printable Version
41 posts in this thread.
Viewing Page :
 1  2 
Forum Information
Currently it is Tuesday, June 19, 2018 8:27 PM (GMT -6)
There are a total of 2,973,442 posts in 326,102 threads.
View Active Threads


Who's Online
This forum has 160984 registered members. Please welcome our newest member, victoriawhite.
465 Guest(s), 12 Registered Member(s) are currently online.  Details
dinkydonuts, victoriawhite, TSGlassman, Reltnie, Coral, Mercy&Grace, jmhri, WalkingbyFaith, Mark FW, RAbid, U.C.Me?, Lvg123