Inflamed Gut Lining because of Leaky Gut Syndrome
When the gut lining is inflamed the protective coating of lgA (immunoglobulin A) is negatively affected. The body is unable to ward off bacteria, viruses and parasites as well as fungus and yeasts like Candida. These pathogenic bad organisms then pass from the gut cavity into the bloodstream and set up infection anywhere else in the body.
Formation of Antibodies with Leaky Gut Syndrome
Formation of antibodies may occur. They leak across and look similar to antigens on our own tissues. So when an antibody is made to attack it, it also attacks the tissue. This is possibly how auto-immune and chronic disease like Crohn's Disease, Rheumatoid arthritis, Lupus, Multiple Sclerosis, and Thyroiditis start.
And as stated in the link I posted....
"Under normal conditions our gastro-intestinal tract is lined with cells that block the contents of the gut from leaking into the intestine," explains Professor Cormac Taylor from the UCD Conway Institute, University College Dublin, one of the principal scientists involved in the discovery. "However, when a person is suffering from IBD this barrier is broken and the contents of the gut leak out into surrounding areas."
"When we applied the new drugs, the gut was tricked into thinking that it was being deprived of oxygen and this activated protective pathways which in turn prevented the death of the cells that line the gastrointestinal tract," continues Professor Taylor.