Yes, it's normal through my experience as well. I started at 12 when I was flaring and originally put on it. I've managed to get down to 4 and plan to stay at this dose as it seems to be keeping me in remission. I know others use 6 and 9 I think is most common. I do notice that if I miss a few doses that my stool is more solid however wouldn't recommend missing your doses. I know when I was on 12 it was a lot to take and I think I am better with 4 or 6 as 12 was overwhelming.