daughter put on 6mp

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jayce
Regular Member


Date Joined Nov 2007
Total Posts : 401
   Posted 1/18/2008 10:02 AM (GMT -6)   
yesterday 6mp was added to all the other stuff, i am very upset, has anyone acheived remission with this plus the colazol and rectal meds.i am way to out of it to research this second any help would be apppreciated, how long has this drug been used for uc and do they have uc people on it for years and years, or is it a crash and burn works for a whil-if it works- and then stops-.
she will be having a cat scan today and a colonoscopy/endoscopy on tuesday, thr dr said she will determine after all blood work and test are completed if she will add prednisone.need some help on this 6mp-flaring badly had about 2 good weeks around christmas but going all night and day with blooody d. eye infection of concer- eye dr did not think it looked like iritis, is treating for pink eye, but gi dr raised an eyebrow.-thanks
Mom to 19 year old daughter diagnosed 11/07.
asacol 2 3x daily-discontinued
colazal 3 3x daily/switched to 4 4x daily
proctofoam 3x daily/1-2xdaily
mesalamine enema 1x daily
canasa suppostiories 3x daily /switched to court supp 1-2x daily
culturelle probiotic 1 daily/switched to danon activiea?
chewable vitamin
hydrocortisone enema at bed time


princesa
Veteran Member


Date Joined Aug 2007
Total Posts : 2204
   Posted 1/18/2008 10:08 AM (GMT -6)   
6mp is an immunosuppresant. It generally takes a while for it to kick in, if it's going to work. I was told it could take 3-4 months. I didn't see any improvement and had alot of unpleasant side effects, so I was taken off of it.
Diagnosed with ulcerative colitis spring 1999
 
Therapeutic dose sulfasalazine.
Probiotics, l-glutamine and fish oil caps. George's aloe vera juice and Mucosaheal.
 
 


Red_34
Elite Member


Date Joined Apr 2004
Total Posts : 23551
   Posted 1/18/2008 10:26 AM (GMT -6)   
6mp worked pretty well for me and it still does. I still have flares but not as severe as when I wasn't on it. I started seeing an improvement at the 7 week mark but the full affect did hit me until around 3 months. I've been on 6mp little over a year now. Yes there are usually side effects in the beginning which can be nausea, hair loss, fatigue and headaches but once her body becomes accustomed to it, all that should subside.
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~Left sided Uc -'92 - Colazal (9 daily), 6mp (50-100mgs), Colocort, Prilosec, Biotin, Forvia, Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa** ~Allergies - Allegra & Singulair
~Secondary Reynauds Syndrome - '04 - Norvasc~Fibromyalgia - '06~No meds
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dakotagirl
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Date Joined Apr 2006
Total Posts : 3402
   Posted 1/18/2008 10:31 AM (GMT -6)   
I've been on Imuran for over a year now. Imuran is similar to 6MP - they are both immunosuppresants.

Imuran and Rowasa were the only things that could get me off of pred and out of a flare in 2006. I was steroid dependent and had been on pred for about six months when I started Imuran. It does take 2-3 months, on average, to take effect.
Pan-colitis and GERD diagnosed May 2003
 
Asacol 12 per day,  Azathioprine 75mg, Aciphex, Effexor XR, Forvia and a Probiotic
Osteopenia (hip and spine) from prednisone use.  Started Azathioprine because I was steroid dependent.
 
Co-Mod for the UC forum
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Westcoast Joe
Regular Member


Date Joined Apr 2005
Total Posts : 130
   Posted 1/19/2008 2:14 PM (GMT -6)   
I'm on 6mp and have been for 3 months. I have seen no results, but have been told it takes 3-6 months to work. I did have a problem with my liver caused by 6mp. thay gave me another drug to work with the 6mp and now I'm fine. good luck, westy

JewelsOK
Regular Member


Date Joined Jun 2007
Total Posts : 364
   Posted 1/19/2008 2:41 PM (GMT -6)   
My 8 year old is currently on 6mp and colazal and just about weaned off of Prednisone (down to 1mg every other day for one more week and then done!!) She is doing very well! She started it in August

My 16 year old son is on Imuran since July - his liver and white blood counts did not do well on 6mp, but Imuran is a bit better. The drugs are closely related. Sometimes his liver levels are very slightly elevated, but not real bad. He is doing really well at this time, too. He had been flaring for over a year when we started the Imuran and Prednisone. He has been of the pred. since Sept. (I think).

I hope your daughter find some relief soon. This disease is so hard to deal with, especially with children!!
Julie - Mom of Son 16 UC dx 07/02, Sulfasalazine, Imuran, folic acid, L. Reuteri, Zyrtec, Iron, Biotin, Vit/Min
& Daughter 8 UC dx 08/07 Colazal, Prednisone, 6MP, Iron, Vit/Min.


jblue65
Regular Member


Date Joined Jan 2008
Total Posts : 381
   Posted 1/19/2008 2:48 PM (GMT -6)   
I just went on 6MP this week - in addition to prednisone 15mg, Remicade, Lialda 4x daily, and Rowasa. For the past week I have had some pain and D but it hasn't lasted a full day or days like before. Now, after about 3 hours, I feel ok. when I feel the pain and cramping coming on I take Symax which helps with the spasming.

Do I worry about all of this medication? Yes, but for the first time in several months I am feeling OK. I am happy- take one day at a time and hope that all of these things will help with remission

I truly hope that your daughter gets some relief from the medications- SHe was diagnosed recently, but Remicade is something that you might want to start researching. I was diagnosed January 07 and had to change doctors- the first one stop taking my insurance, the second one was horrible- I blame him for not helping me to control the UC- my UC had spread past rectum, and as soon as the third one saw me he put me on Remicade and 20 mg of Prednisone.

I wish your daughter the best.

UChick
Regular Member


Date Joined Jun 2006
Total Posts : 173
   Posted 1/19/2008 7:26 PM (GMT -6)   
I take Azathioprine which is similar to 6-MP. I've been on it since summer 2002 and my GI believes that this is what put me into remission and what has kept me in remission since that summer. Your daughter seems to be on a lot of meds, but hopefully once her UC is under more control her doctor will ween her off some of those.

http://www.cnn.com/HEALTH/library/DS/00598.html

Immune system suppressors
These drugs also reduce inflammation, but they target your immune system rather than treating inflammation itself. Because immune suppressors can be effective in treating ulcerative colitis, scientists theorize that damage to digestive tissues is caused by your body's immune response to an invading virus or bacterium or even to your own tissue. By suppressing this response, inflammation is also reduced. Immunosuppressant drugs include:

* Azathioprine (Imuran) and mercaptopurine (Purinethol). These drugs have been used to treat Crohn's disease for years, but their role in ulcerative colitis is only now being studied. Because azathioprine and mercaptopurine act slowly, they're sometimes initially combined with a corticosteroid, but in time, they seem to produce benefits on their own, with less long-term toxicity. Side effects are not minor, however, and can include allergic reactions, bone marrow suppression, infections, and inflammation of the liver and pancreas.
Age 17

Diagnosed September '01
Remission since July '02

Asacol- 4 pills 3xday
Azathioprine- 75mg 1xmorning
Took Remicade 3 times, BIG FAN!!!!


jayce
Regular Member


Date Joined Nov 2007
Total Posts : 401
   Posted 1/19/2008 11:50 PM (GMT -6)   
thanks for all of your answers-as usual this disease gets a mixed bag of reactions.

u chick-if you were doing well with the aza why did you use remicade, are you still going to have to use them both?
Mom to 19 year old daughter diagnosed 11/07.
asacol 2 3x daily-discontinued
colazal 3 3x daily/switched to 4 4x daily
proctofoam 3x daily/1-2xdaily
mesalamine enema 1x daily
canasa suppostiories 3x daily /switched to court supp 1-2x daily
culturelle probiotic 1 daily/switched to danon activiea?
chewable vitamin
hydrocortisone enema at bed time


basa0806
Veteran Member


Date Joined Feb 2005
Total Posts : 2103
   Posted 1/20/2008 1:34 AM (GMT -6)   
I never personally had any success with 6mp. All it did was make in completely impossible for me to fight of mono!! However, my cousin's husband was in REALLY rough shape, almost to the point of surgery and he tried imuran and I think he's been in remission for something like 5 years. Its always different for everyone.
Hope your daughter starts to feel better!

Sam

p.s I'm 19 too and I'm sure my mom can related to worries :)

Sam

Diagnosed in September 2004

Currently on...4800mg Asacol, 25mg Elavil, Ortho Tricyclen and some immodium

"If you don't like something, change it. If you can't change it, change your attitude"

Maya Angelou


jayce
Regular Member


Date Joined Nov 2007
Total Posts : 401
   Posted 1/20/2008 9:53 AM (GMT -6)   
sam-i'm sure you're right about your mom relating to me- i know i'm not the sick one, but i am suffering every second of the day, i hope all of our kids get better fast!
no one should suffer like this!
Mom to 19 year old daughter diagnosed 11/07.
asacol 2 3x daily-discontinued
colazal 3 3x daily/switched to 4 4x daily
proctofoam 3x daily/1-2xdaily
mesalamine enema 1x daily
canasa suppostiories 3x daily /switched to court supp 1-2x daily
culturelle probiotic 1 daily/switched to danon activiea?
chewable vitamin
hydrocortisone enema at bed time


princesscolon
Veteran Member


Date Joined Apr 2006
Total Posts : 733
   Posted 1/20/2008 10:36 AM (GMT -6)   
I've heard what everyone else has said, that 6mp can take a few months to really see a difference so you have to be patient with it, that some people see a great improvement on it and others don't. The dreaded Prednisone should help things settle down in the meantime so she can feel a little better although it creates its own problems, it is a quick fix that works for pretty much everybody. I hope she can get back to more of what a young woman should feel like. It is a shame she needs all those tests when she is feeling so bad as it is. Why is she getting all those tests? When was her last colonoscopy if you don't mind me asking?
Diagnosed with Left-sided Ulcerative Colitis 1995 at 15
Tried: Prednisone, Rowasa & Hydrocortisone Enemas, Proctofoam, Sulfasalazine, Asacol, Probiotics, Fish Oil, Canasa, Enotcort, Colazol, Proctocort, Anamantle, etc...
Diagnosed with Ulcerative Proctitis with almost rectovaginal fistula in 2004, put on Remicade, August 2007:Increased Remicade dosage-700mg every 6 weeks,diagnosed with Psoriatic Arthritis & Fibromyalgia Current meds: Remicade 700mgs every 6 wks (had reaction, will start Humira Jan 29) Clorazepate, Proctofoam HC, Glucosamine 500, Vitamin B, Lomotil as needed, Darvocet, Tylenol pm


UChick
Regular Member


Date Joined Jun 2006
Total Posts : 173
   Posted 1/20/2008 10:44 PM (GMT -6)   
PLEASE- My first remicade treatment if I remember correctly was about the same time I started Azathioprine, which was somewhere around June of 2002. It takes a few months to really kick in. I was in the hospital at the time with my second flare and they wouldn't let me out of the hospital until they were sure I was better. One of my GI's suggested it to me (and my family) and I would have tried anything to get out of the hospital. They administered it to me while I was in the hospital. I believe it put me into remission and I was able to leave the hospital. I had two other remicade treatments that stopped mini-flares from becoming big ones. I had two through the hospital and the last one I had to go to some place where they specifically do remicade treatments.

I'll probably have to be on Azathioprine and Asacol for awhile. I've passed the five year remission mark and haven't had any problems. However, with college coming up I don't want to "fix something that isn't broken." After college though I guess I'll have to take it by ear. Hopefully, I can ween down to a lower dosage of Asacol. For now though I'm too scared to change anything in fear that my UC will come back.
Age 17

Diagnosed September '01
Remission since July '02

Asacol- 4 pills 3xday
Azathioprine- 75mg 1xmorning
Took Remicade 3 times, BIG FAN!!!!


Severin
Regular Member


Date Joined Oct 2007
Total Posts : 320
   Posted 1/20/2008 10:45 PM (GMT -6)   
PLEASE - 6-MP takes ages to "kick in". It only really even starts to take effect in the body after 3 to 4 months. For me, it took 6.

With regard to Remicade, yes - in my case I am on a trial drug called Abatacept which has similar risks involved. I am glad I did as I believe this was one of the major things that has helped reign this flare back in and help me get off prednisone.

To be honest, my take is this with regard to the risks of Biologics - I would rather live a life span of 50 years, with a full 50 years of full quality of life, rather then 80 years unhappy and stuck on the toilet all day and feeling trapped.
"We are dreamers, shapers, singers and makers..." - Elric, elder Technomage
    - 2xColazide, twice a day; 1x6-mp twice a day; 1xAbatacept 10mg/kg per month;
    - 1xZinc per day, 2xScoop of Sustagen Sport per day;
    - 1xBIOCeuticals UltraBiotic 45 per day, 1xBIOCeuticals SB FlorActiv per day;
    - 1xHeaped teaspoon of Metamucil smooth orange powder 3 times a day.

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