Steroid vs 5-ASA Enema

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Regular Member

Date Joined Apr 2006
Total Posts : 172
   Posted 1/18/2008 12:08 PM (GMT -6)   
Hi there,

Can someone please tell me which enema is more effective in healing the end of the colon, steroid or 5-ASA?

My Gi tells me most of the damage in my colon is at the end, so I suppose enemas are the way to go...

What about Butyrate Enemas, has anybody tried them?


Regular Member

Date Joined May 2005
Total Posts : 221
   Posted 1/18/2008 1:48 PM (GMT -6)   


I also have proctitis, and my GI started me on 5 ASA enemas first before she wanted to try steroid ones.  Lucky me the 5 ASA have been working.  I had been bleeding for almost 6 months, and saw an immediate improvement with them :)  I would much rather be treated with those than steroids if at all possible...I'm also on 8 Salofalk (5ASA) tablets/day too for maintenance. 

Hope that helped :)



Elite Member

Date Joined May 2003
Total Posts : 30984
   Posted 1/18/2008 4:31 PM (GMT -6)   
5ASA retention enemas are the way to go firstly.....but if you can't use them because of intolerance, the steroid enemas would be next.

I'm biased since they've worked for 19 years (as well as with the Asacol).
All UCers have rectal inflammation ( no matter how much is involved)...rectal meds are a must regardless....


*Heather*Status: mini flare Dec 28... increased enemas to nightly
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....bromelain 1 - 2x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!

Regular Member

Date Joined Jan 2008
Total Posts : 154
   Posted 1/18/2008 4:45 PM (GMT -6)   
My doctor has never discussed enema's with me what are they self-admistered? What is the process? Is there alot of discomfort?
Diagnosed in spring 2005 at age 28
Currently on 12 asacol pills a day + Entocort

Elite Member

Date Joined Apr 2004
Total Posts : 23551
   Posted 1/18/2008 5:32 PM (GMT -6)   
Disco, yes the enemas are self administered usually at night. Discomfort depends on several factors - how inflammed you are, if you accidently get air because you didn't squeeze it out before inserting, a cold enema can cause cramping. How they are administered is found on the box. I too believe that regardless of where your inflammation is - rectal or thru out - that enemas can help clear up symptoms and least offer some relief.
Moderator for Allergies/Asthma and Co-moderator for UC
~Left sided Uc -'92 - Colazal (9 daily), 6mp (50-100mgs), Colocort, Prilosec, Biotin, Forvia, Pro-Bio**Unable to tolerate Asacol, Rowasa or Canasa** ~Allergies - Allegra & Singulair
~Secondary Reynauds Syndrome - '04 - Norvasc~Fibromyalgia - '06~No meds
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Regular Member

Date Joined Jan 2008
Total Posts : 27
   Posted 1/18/2008 9:13 PM (GMT -6)   
I have been on 8 Salofalk pills a day plus a Salofalk enema and they have helped but I still need more improvement. Just today after my sigmoidoscopy my doc has now put me on steroid enemas... so hopefully they will help with my urgency since that is my main problem..

Chris 21/M
Diagnosed Sept. 07
Salofalk 500mg plus nightly enema
Steroid enema
Fish Oil, Multivitamin
Status: 1-3 BMs a day. Each one D or lose and each one urgent!

Regular Member

Date Joined Feb 2007
Total Posts : 159
   Posted 1/18/2008 9:33 PM (GMT -6)   
I have a hard time with enemas, but I use Canasa suppositories as needed between my Remicade treatments. Canasa is a 5-ASA drug. It works good for me.

meds: UC diagnosed 1990; Remicade - 1 year, Canasa suppositories as needed, vitamins and other supplements
Severe reaction to 6MP; Severe nausea and steady unwanted weight loss on Asacol

Old Hat
Veteran Member

Date Joined Feb 2007
Total Posts : 5190
   Posted 1/22/2008 12:41 AM (GMT -6)   
Steroid retention enemas are the way to go if you have a lot of friable tissue in the sigmoid colon & rectum. They can also heal the descending colon thru systemic (rather than topical) effect, but this can take a couple months or more. The mesalamine retention enemas are slower-acting than the steroids, but they can get you to remission in a month or 2 if you have mild to moderate inflammation in proctosigmoid areas. These are the liquid enemas; there is also a 10% steroid rectal foam (Cortifoam in U.S.) that can speed healing in the rectum. Alas, the U.S. & Canada do not yet have the mesalamine rectal foam that has been available for some time in Australia, the U.K. & Europe. The key to using these meds successfully: diligence + patience. / Old Hat (nearly 30 yrs with left-sided UC; currently on 3 Colazal daily for maintenance of remission)
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